Abstract: Neurotrophin receptor binding conjugate compositions for delivering an active agent to nerve cells are provided. Conjugate compositions of the present disclosure according to certain embodiments include a one or more active agent compounds (e.g., a dye or small molecule therapeutic) covalently bonded to a protein, peptide or peptidomimetic that binds selectively to a neurotrophin receptor. In embodiments of the compositions, the average ratio of active agent compound to protein, peptide or peptidomimetic in the conjugates is 5 or less. Dual color imaging compositions are also described. Methods for delivering an active agent conjugate selectively into nerve cells (e.g., intraocular delivery) are provided.

Abstract: The disclosure relates polyoxometalate complexes and uses in the management, treatment, or prevention of cancer. In certain embodiments, the polyoxometalate complexes comprise polydentate oxygen bridging ligands such as those of the following formula: [POM{(OCH2)3CX}2], [M6O13{(OCH2)3CX}2], [V6O13{(OCH2)3CX}2], salts, or derivatives thereof wherein POM is a polyoxometalate, M is a metal, and X is defined herein. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising polyoxometalate complexes disclosed herein.

Abstract: The disclosure relates polyoxometalate complexes and uses in the management, treatment, or prevention of cancer. In certain embodiments, the polyoxometalate complexes comprise polydentate oxygen bridging ligands such as those of the following formula: [POM{(OCH2)3CX}2], [M6O13{(OCH2)3CX}2], [V6O13 {(OCH2)3CX}2], salts, or derivatives thereof wherein POM is a polyoxometalate, M is a metal, and X is defined herein. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising polyoxometalate complexes disclosed herein.

Abstract: This disclosure relates to polymers and polymer compositions having monomer units of polyoxometalates and monomer units comprising hydroxy-terminated molecules such as branched molecules or dendrimers and uses in degradation, decontamination, and deodorization. In certain embodiments, the hydroxy-terminated branched molecules or dendrimers comprise terminal 1,1-tris(hydroxymethyl)methyl or 1,1,1-tris(hydroxyalkyl)methyl groups. In certain embodiments, the hydroxy-terminated molecule is N,N?,N?-tris[tris(hydroxymethyl) methyl]-1,3,5-benzenetricarboxamide.

Abstract: A self-aligning mechanism is described and may include a first coarse guide component connected to a first device and a second coarse guide component connected to a second device, the first coarse guide component configured to interact with the second coarse guide component to positionally align a connector pair, the coarse guide components configured to prevent a connector from being inserted into a connector receptacle until the connector and the connector receptacle are positionally aligned. The mechanism may also include a first fine guide component connected to the first device and a second fine guide component connected to the second device, the first fine guide component configured to interact with the second fine guide component to rotationally align the connector with the connector receptacle, the fine guide components configured to prevent the connector from being inserted into the connector receptacle until the connector and the connector receptacle are rotationally aligned.

Abstract: The disclosure relates polyoxometalate complexes and uses in the management, treatment, or prevention of cancer. In certain embodiments, the polyoxometalate complexes comprise polydentate oxygen bridging ligands such as those of the following formula: [POM{(OCH2)3CX}2], [M6O13{(OCH2)3CX}2], [V6O13{(OCH2)3CX}2], salts, or derivatives thereof wherein POM is a polyoxometalate, M is a metal, and X is defined herein. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising polyoxometalate complexes disclosed herein.

Abstract: This disclosure relates to polymers and polymer compositions having monomer units of polyoxometalates and monomer units comprising hydroxy-terminated molecules such as branched molecules or dendrimers and uses in degradation, decontamination, and deodorization. In certain embodiments, the hydroxy-terminated branched molecules or dendrimers comprise terminal 1,1-tris(hydroxymethyl)methyl or 1,1,1-tris(hydroxyalkyl)methyl groups. In certain embodiments, the hydroxy-terminated molecule is N,N?,N?-tris[tris(hydroxymethyl) methyl]-1,3,5 -benzenetricarboxamide.

Abstract: A self-aligning mechanism is described and may include a first coarse guide component connected to a first device and a second coarse guide component connected to a second device, the first coarse guide component configured to interact with the second coarse guide component to positionally align a connector pair, the coarse guide components configured to prevent a connector from being inserted into a connector receptacle until the connector and the connector receptacle are positionally aligned. The mechanism may also include a first fine guide component connected to the first device and a second fine guide component connected to the second device, the first fine guide component configured to interact with the second fine guide component to rotationally align the connector with the connector receptacle, the fine guide components configured to prevent the connector from being inserted into the connector receptacle until the connector and the connector receptacle are rotationally aligned.

Abstract: A chronometer to monitor the passage of time prior to a projected date of birth of a baby and to recognize and celebrate the birth of the baby. The chronometer includes a generally hollow egg-shaped housing including a bottom, a top, a hinge mechanism, and a latching mechanism. The hinge mechanism rotatably connects the top to the bottom so the top can open and close. The latching mechanism releasably connects the top to the bottom. The chronometer also includes a replica of a young chicken housed in the chronometer, and includes a display to indicate the length of time until the projected birth date of the baby.

Abstract: A chronometer to monitor the passage of time prior to a projected date of birth of a baby and to recognize and celebrate the birth of the baby. The chronometer includes a generally hollow egg-shaped housing including a bottom, a top, a hinge mechanism, and a latching mechanism. The hinge mechanism rotatably connects the top to the bottom so the top can open and close. The latching mechanism releasably connects the top to the bottom. The chronometer also includes a replica of a young chicken housed in the chronometer, and includes a display to indicate the length of time until the projected birth date of the baby.

Abstract: A swiveling folding chair is provided. The chair swivels independently of the legs of the chair. The chair includes a drawstring to fold the arms or legs of the chair.

Abstract: A swiveling folding chair is provided. The chair swivels independently of the legs of the chair. The chair includes audio speakers exterior of the back support of the chair.

Abstract: The invention features compounds of the general formula: B-L-M where B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.

Abstract: Compositions, materials incorporating the compositions, and methods of use thereof, for the protection and/or decontamination of contaminants are disclosed.

Abstract: A swiveling folding chair is provided. The chair includes a fabric seat; a plurality of legs; a primary control tree having a first control shaft and having first, second, third, and fourth collars mounted on the control shaft. The legs are each attached to the first control collar, and, support arms are each attached to the second control collar and to the fabric seat. Elongate support members are each attached at one end to one of the legs and at the other end to the fourth control collar. Elongate brace members are each attached at one end to one of the arms and at the other end to the third control collar. The second control collar rotates about the first control collar so the seat rotates independently of the legs. The seat and legs fold into a stowed orientation.

Abstract: The invention features compounds of the general formula: B-L-M where B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.

Abstract: A swiveling folding chair is provided. The chair swivels independently of the legs of the chair. The chair includes audio speakers exterior of the back support of the chair.

Abstract: A swiveling folding chair is provided. The chair swivels independently of the legs of the chair.

Abstract: Compositions, materials incorporating the compositions, and methods of use thereof, for the protection and/or decontamination of contaminants are disclosed.

Abstract: The invention features compounds of the general formula: B-L-M where B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.