Patents by Inventor Craig Husfeld

Craig Husfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biphenyl compounds useful as muscarinic receptor antagonists
    Patent number: 12258316
    Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Grant
    Filed: January 5, 2022
    Date of Patent: March 25, 2025
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Mathai Mammen, YuHua Ji, YongQi Mu, Craig Husfeld, Li Li
  • TRPM8 AGONISTS AS COOLING AGENTS AND FOR THE TREATMENT OF DISEASE
    Publication number: 20240199564
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential melastatin 8 receptor (TRPM8) activity.
    Type: Application
    Filed: February 16, 2022
    Publication date: June 20, 2024
    Inventor: Craig HUSFELD
  • PEGYLATED PRODRUGS OF PHENOLIC TRPV1 AGONISTS
    Publication number: 20230219901
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Application
    Filed: March 16, 2023
    Publication date: July 13, 2023
    Inventors: John F. DONOVAN, Craig HUSFELD
  • Prodrugs of phenolic TRPV1 agonists
    Patent number: 11634384
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: April 25, 2023
    Assignee: CONCENTRIC ANALGESICS, INC.
    Inventors: Craig Husfeld, John F. Donovan
  • PEGYLATED PRODRUGS OF PHENOLIC TRPV1 AGONISTS
    Publication number: 20220388970
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV 1) activity.
    Type: Application
    Filed: August 3, 2022
    Publication date: December 8, 2022
    Inventors: John F. DONOVAN, Craig HUSFELD
  • Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
    Patent number: 11464767
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: October 11, 2022
    Assignee: CONCENTRIC ANALGESICS, INC.
    Inventors: John F. Donovan, Craig Husfeld
  • BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS
    Publication number: 20220306579
    Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: January 5, 2022
    Publication date: September 29, 2022
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Mathai Mammen, YuHua Ji, YongQi Mu, Craig Husfeld, Li Li
  • PEGYLATED PRODRUGS OF PHENOLIC TRPV1 AGONISTS
    Publication number: 20220112165
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 14, 2022
    Inventors: John F. DONOVAN, Craig HUSFELD
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Patent number: 11247969
    Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: February 15, 2022
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Mathai Mammen, YuHua Ji, YongQi Mu, Craig Husfeld, Li Li
  • Pegylated prodrugs of phenolic TRPV1 agonists
    Patent number: 11242325
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: February 8, 2022
    Assignee: CONCENTRIC ANALGESICS, INC.
    Inventors: John F. Donovan, Craig Husfeld
  • PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED LOCAL ANESTHESIA
    Publication number: 20210008050
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Application
    Filed: September 24, 2020
    Publication date: January 14, 2021
    Inventors: John F. DONOVAN, Craig HUSFELD
  • Prodrugs of phenolic TRPV1 agonists
    Patent number: 10851123
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: December 1, 2020
    Assignee: CONCENTRIC ANALGESICS, INC.
    Inventors: Craig Husfeld, Andrei W. Konradi
  • Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
    Patent number: 10821105
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: November 3, 2020
    Assignee: CONCENTRIC ANALGESICS, INC.
    Inventors: John F. Donovan, Craig Husfeld
  • PEGYLATED PRODRUGS OF PHENOLIC TRPV1 AGONISTS
    Publication number: 20200299245
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Application
    Filed: June 8, 2020
    Publication date: September 24, 2020
    Inventors: John F. DONOVAN, Craig HUSFELD
  • BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS
    Publication number: 20200290966
    Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: January 16, 2020
    Publication date: September 17, 2020
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Mathai Mammen, YuHua Ji, YongQi Mu, Craig Husfeld, Li Li
  • Pegylated prodrugs of phenolic TRPV1 agonists
    Patent number: 10717712
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: July 21, 2020
    Assignee: CONCENTRIC ANALGESICS, INC.
    Inventors: John F. Donovan, Craig Husfeld
  • Biphenyl compounds useful as muscarinic receptor antagonists
    Patent number: 10570092
    Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: February 25, 2020
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Mathai Mammen, YuHua Ji, YongQi Mu, Craig Husfeld, Li Li
  • PEGYLATED PRODRUGS OF PHENOLIC TRPV1 AGONISTS
    Publication number: 20200031780
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Application
    Filed: July 25, 2019
    Publication date: January 30, 2020
    Inventors: John F. DONOVAN, Craig HUSFELD
  • BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS
    Publication number: 20190359570
    Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Application
    Filed: May 23, 2019
    Publication date: November 28, 2019
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Mathai Mammen, YuHua Ji, YongQi Mu, Craig Husfeld, Li Li
  • PRODRUGS OF PHENOLIC TRPV1 AGONISTS
    Publication number: 20190284132
    Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
    Type: Application
    Filed: May 30, 2019
    Publication date: September 19, 2019
    Inventors: Craig HUSFELD, John F. DONOVAN