Patents by Inventor Craig J. Forsyth

Craig J. Forsyth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Halichondrins and related compounds
    Patent number: 5436238
    Abstract: Novel chemical compounds that can be used to synthesize halichondrin B and norhalichondrin B, and related derivatives. The total synthesis of halichondrin B and norhalichondrin B is also disclosed.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: July 25, 1995
    Assignee: President and Fellows of Harvard College
    Inventors: Yoshito Kishi, Francis G. Fang, Craig J. Forsyth, Paul M. Scola, Suk K. Yoon
  • Synthesis of halichondrin B and norhalichondrin B
    Patent number: 5338865
    Abstract: Novel chemical compounds that can be used to synthesize halichondrin B and norhalichondrin B, and related derivatives, are described. The synthesis of halichondrin B and norhalichondrin B from these compounds also is described.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: August 16, 1994
    Assignee: President and Fellows of Harvard College
    Inventors: Yoshito Kishi, Francis G. Fang, Craig J. Forsyth, Paul M. Scola, Suk K. Yoon
  • Creatine analogs having antiviral activity
    Patent number: 5321030
    Abstract: The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such as Herpes viruses (e.g., HSV-1, HSV-2, cytomegaloviruses, Varicella-Zoster virus) and adenovirus. The invention further relates to creatine analogs including four classes of creatine analogs selected as candidate antiviral compounds: (1) creatine analogs that can be phosphorylated by creatine kinase but differ in their phosphoryl group transfer potential, (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine, (3) creatine analogs which can act as irreversible inhibitors of creatine kinase, and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: June 14, 1994
    Assignee: Amira, Inc.
    Inventors: Rima Kaddurah-Daouk, James W. Lillie, Theodore S. Widlanski, Jonathan J. Burbaum, Craig J. Forsyth