Patents by Inventor Craig J. McClain

Craig J. McClain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF PROBIOTIC BACTERIUM-DERIVED EXTRACELLULAR MICRO- AND/OR NANOPARTICLES FOR THE TREATMENT OF DISEASE
    Publication number: 20240009256
    Abstract: Provided are probiotic bacterium-derived extracellular micro- and/or nanoparticles.
    Type: Application
    Filed: February 4, 2021
    Publication date: January 11, 2024
    Applicant: University of Louisville Research Foundation, Inc.
    Inventors: Wenke Feng, Craig J. McClain
  • Method for treating a viral infection related or a chemical toxin related hepatic injury with deltorphin D
    Patent number: 7335642
    Abstract: A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: February 26, 2008
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter R. Oeltgen, Paul D. Bishop, Craig J. McClain, Shirish Barve
  • Method for treating cytokine mediated hepatic injury
    Patent number: 6875742
    Abstract: A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: April 5, 2005
    Assignees: ZymoGenetics, Inc., University of Kentucky Research Foundation
    Inventors: Peter R. Oeltgen, Paul D. Bishop, Craig J. McClain, Shirish Barve
  • Method for treating cytokine mediated hepatic injury
    Publication number: 20020103124
    Abstract: A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO: 1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
    Type: Application
    Filed: October 5, 2001
    Publication date: August 1, 2002
    Applicant: University of Kentucky Research Foundation
    Inventors: Peter R. Oeltgen, Paul D. Bishop, Craig J. McClain, Shirish Barve
  • Method for treating cytokine mediated hepatic injury
    Patent number: 6380164
    Abstract: A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: April 30, 2002
    Assignees: University of Kentucky Research Foundation, ZymoGenetics
    Inventors: Peter R. Oeltgen, Craig J. McClain, Shirish Barve, Paul D. Bishop