Patents by Inventor Craig J. Thomas

Craig J. Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Activators of human pyruvate kinase
    Patent number: 8937067
    Abstract: Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia,
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: January 20, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Craig J. Thomas, Douglas S. Auld, James Inglese, Amanda P. Skoumbourdis, Jian-Kang Jiang, Matthew B. Boxer
  • LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS
    Publication number: 20140301944
    Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
    Type: Application
    Filed: April 2, 2014
    Publication date: October 9, 2014
    Applicants: Forschungsverbund Berlin E.V., The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Marvin C. Gershengorn, Susanne Neumann, Bruce M. Raaka, Craig J. Thomas, James Inglese, Noel T. Southall, Steven Titus, Wenwei Huang, Gerd Krause, Gunnar Kleinau, Wei Zheng
  • Activators of the human pyruvate kinase M2 receptor
    Patent number: 8841305
    Abstract: Disclosed are pyruvate kinase M2 activators, which are bis sulfonamide piperazinyl and piperidinyl compounds of Formula (I), 2,4-disubstituted 4H-thieno[3,2-c]pyrrole-2-(substituted benzyl)pyridazin-3(2H)-ones of Formula (II) and 6-(3,4-dimethylphenylaminosulfonyl)-3,4-dihydro-1H-quinolin-2-one of formula (III), wherein L, R1, R2, R11 to R16, R21 and R22 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: September 23, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Craig J. Thomas, Douglas S. Auld, James Inglese, Amanda P. Skoumbourdis, Jian-Kang Jiang, Matthew B. Boxer
  • Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists
    Patent number: 8741259
    Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: June 3, 2014
    Inventors: Marvin C. Gershengorn, Susanne Neumann, Bruce M. Raaka, Craig J. Thomas, James Inglese, Noel T. Southall, Steven Titus, Wei Zheng, Wenwei Huang, Gerd Krause, Gunnar Kleinau
  • LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS
    Publication number: 20130251631
    Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
    Type: Application
    Filed: May 17, 2013
    Publication date: September 26, 2013
    Applicants: Forschungsverbund Berlin E.V., The Government of the United States of America as represented by the Secretary of the Department of
    Inventors: Marvin C. Gershengorn, Susanne Neumann, Bruce M. Raaka, Craig J. Thomas, James Inglese, Noel T. Southall, Steven Titus, Wei Zheng, Wenwei Huang, Gerd Krause, Gunnar Kleinau
  • ACTIVATORS OF HUMAN PYRUVATE KINASE
    Publication number: 20130109672
    Abstract: Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A1, A2, L, R, R1 to R3, X1 to X3, k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A1-NR-L-A2 (I).
    Type: Application
    Filed: April 26, 2011
    Publication date: May 2, 2013
    Applicant: The United States of America,as represented by the Secretary, Department of Health and Human Service
    Inventors: Matthew B. Boxer, Min Shen, Douglas S. Auld, Craig J. Thomas, Martin J. Walsh
  • INVERSE AGONISTS AND NEUTRAL ANTAGONISTS FOR THE TSH RECEPTOR
    Publication number: 20120315217
    Abstract: TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer.
    Type: Application
    Filed: April 8, 2011
    Publication date: December 13, 2012
    Inventors: Marvin Gershengorn, Susanne Neumann, Wenwei Huang, Craig J. Thomas
  • ACTIVATORS OF HUMAN PYRUVATE KINASE
    Publication number: 20120245141
    Abstract: Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia,
    Type: Application
    Filed: March 29, 2012
    Publication date: September 27, 2012
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Craig J. Thomas, Douglas S. Auld, James Inglese, Amanda P. Skoumbourdis, Jian-Kang Jiang, Matthew B. Boxer
  • OXADIAZOLE-2-OXIDES AS ANTISCHISTOSOMAL AGENTS
    Publication number: 20110207784
    Abstract: The invention provides 1,2,5-oxadiazole-containing compounds of Formula (I), wherein R1, A, and R2 are as defined herein, that are useful in treating schistosomiasis. The invention also provides a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, and a method of treating schistosomiasis in a mammal.
    Type: Application
    Filed: August 13, 2009
    Publication date: August 25, 2011
    Applicants: DEPARTMENT OF HEALTH AND HUMAN SERVICES, ILLINOIS STATE UNIVERSITY
    Inventors: Craig J. Thomas, David J. Maloney, Ganesha Rai Bantukallu, Ahmed A. Sayed, Anton Simeonov, David L. Williams
  • ACTIVATORS OF HUMAN PYRUVATE KINASE
    Publication number: 20110195958
    Abstract: Disclosed are pyruvate kinase M2 activators, which are bis sulfonamide piperazinyl and piperidinyl compounds of Formula (I), 2,4-disubstituted 4H-thieno[3,2-c]pyrrole-2-(substituted benzyl)pyridazin-3(2H)-ones of Formula (II) and 6-(3,4-dimethylphenylaminosulfonyl)-3,4-dihydro-1H-quinolin-2-one of formula (III), wherein L, R1, R2, R11 to R16, R21 and R22 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia.
    Type: Application
    Filed: October 9, 2009
    Publication date: August 11, 2011
    Applicant: US Dept. of Health and Human Services
    Inventors: Craig J. Thomas, Douglas S. Auld, James Inglese, Amanda P. Skoumbourdis, Jian-Kang Jiang, Matthew B. Boxer
  • LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS
    Publication number: 20110195018
    Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
    Type: Application
    Filed: October 20, 2008
    Publication date: August 11, 2011
    Inventors: Marvin C. Gershengorn, Susanne Neumann, Bruce M. Raaka, Craig J. Thomas, James Inglese, Noel T. Southall, Steven Titus, Wei Zheng, Wenwei Huang, Gerd Krause, Gunnar Kleinau
  • PHOSPHODIESTERASE INHIBITORS
    Publication number: 20110112079
    Abstract: The invention related to compounds for formula I useful for inhibiting phosphodiesterase-4.
    Type: Application
    Filed: January 8, 2009
    Publication date: May 12, 2011
    Inventors: Craig J. Thomas, Menghang Xia, Amanda P. Skoumbourdis, Christopher A. LeClair, Ruili Huang, Martin J. Walsh
  • Pyrimidine low molecular weight ligands for modulating hormone receptors
    Publication number: 20090203716
    Abstract: Disclosed herein are small molecule modulators hormone receptors, including agonists and antagonists of luteinizing hormone/choriogonadotropin, follicle stimulating hormone and thyroid stimulating hormone receptors. Exemplary disclosed compounds include those of the formula wherein X is —S(O)nR5; n is 0, 1 or 2; Y is —OR6 or —NR7R8 R1 and R2 independently are selected from optionally substituted lower aliphatic, alkoxy, aralkyl, halogen, H and —OR5, wherein R5 is selected from lower alkyl, H, aralkyl, acyl, alkoxycarbonyl and aminocarbonyl; R3 and R4 independently are selected from acyl, alkoxycarbonyl, aminocarbonyl, aralkyl, H, lower alkyl and cycloalkyl; R5 is selected from lower alkyl, aralkyl, cycloalkyl and haloalkyl; R6 is selected from H, lower alkyl and aralkyl; R7 and R8 independently are selected from H, lower alkyl, aralkyl and cycloalkyl.
    Type: Application
    Filed: November 14, 2008
    Publication date: August 13, 2009
    Inventors: Marvin C. Gershengorn, Susanne Neumann, Craig J. Thomas, Holger Jaeschke, Susanna Moore, Gerd Krause, Bruce Raaka, Ralf Paschke, Gunnar Kleinau