Abstract: Arylsulfonamides of 4-heteroaryl-cyclohexyls, and their derivatives, are competitive and non-competitive inhibitors of the muscarinic acetylcholine receptor M5 (mAChR M5) and have utility in the treatment of psychiatric disorders such as substance-related misuse, substance-related disorder relapse, anxiety, depression, and psychosis.

Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Disclosed herein are compounds of formula (III) useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurodegenerative disorders using the compounds and compositions.

Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Methods and devices for determining sensing device usability, e.g., for point of care immunoassay devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a continuous polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the continuous polymer layer; and determining whether the measured electrical property associated with the continuous polymer layer has exceeded a threshold level associated with the device usability.

Abstract: The present application discloses an apparatus for determining and displaying gear ratios in a transmission system having a driving sprocket set, a driven sprocket set and a flexible drive member that engages the driving sprocket set and driven sprocket set, the apparatus comprising a display, a sensing module, the sensing module comprising a plurality of magneto-resistive assemblies, wherein at least one of the plurality of magneto-resistive assemblies is configured to detect adjustment of the transmission system, the sensing module configured to generate a signal responsive to said adjustment of the transmission system, and a data processor communicatively coupled with the display and with the sensing module, the data processor configured to receive the signal generated by the sensing module, process the signal to generate data relating to sprockets engaged by the flexible drive member, and write the data to the display.

Abstract: Among other things, one or more techniques and/or systems are disclosed for rendering query results. After a user submits a query, a plurality of query results may be received, comprising at least a first query result and a second query result. The first query result can be rendered in a first collapsed view, which may be smaller and may comprise less information than a full view of the first query result. Upon receiving a first indication of scrolling, hinting that the user may wish to view more results, the first query result can be rendered in a first expanded view, which may comprise a full view of the first query result. Further, upon receiving the first indication of scrolling, the second query result can be rendered in a second collapsed view. Rendering query results as provided herein allows a (limited) viewable area to be used in an efficient manner.

Abstract: Methods and devices for determining sensing device usability, e.g., for point of care immunoassay devices. In one embodiment, the invention is to a method of determining device usability, comprising the steps of providing a device comprising a first electrical pad; a second electrical pad; and a continuous polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the continuous polymer layer; and determining whether the measured electrical property associated with the continuous polymer layer has exceeded a threshold level associated with the device usability.

Abstract: Methods and devices for correcting sensing device signals, e.g., for point of care immunoassay devices. In one embodiment, the invention is to a method of correcting a signal in a sensing device, comprising the steps of: providing a sensing device comprising a sensor, a first electrical pad, a second electrical pad, and a continuous polymer layer contacting at least a portion of the first and second electrical pads; applying a potential across the first and second electrical pads; measuring an electrical property associated with the continuous polymer layer; determining a correction factor associated with the measured electrical property; and applying the correction factor to a signal generated by the sensor to produce a corrected signal.

Abstract: The present application discloses an apparatus for determining and displaying gear ratios in a transmission system having a driving sprocket set, a driven sprocket set and a flexible drive member that engages the driving sprocket set and driven sprocket set, the apparatus comprising a display, a sensing module, the sensing module comprising a plurality of magneto-resistive assemblies, wherein at least one of the plurality of magneto-resistive assemblies is configured to detect adjustment of the transmission system, the sensing module configured to generate a signal responsive to said adjustment of the transmission system, and a data processor communicatively coupled with the display and with the sensing module, the data processor configured to receive the signal generated by the sensing module, process the signal to generate data relating to sprockets engaged by the flexible drive member, and write the data to the display.

Abstract: A method, device and system for utilizing a pixelized ungated linear array of field emitters and an integrated electrode-media surface to either detect the presence of charge on the surface in a given two-dimensional pattern, or to deposit charge on the surface in a desired two-dimensional pattern. The methods, devices and systems disclosed are particularly useful in the arts of printing, scanning and copying. In one embodiment designed for printing, a pixelized surface may be utilized to receive a charge pattern from the ungated linear field emitter array. In one embodiment designed for scanning, a pixelized transfer sheet may be utilized to transfer a two-dimensional charge pattern from a photostatic surface thereto for sensing and detection by the ungated linear field emitter array.

Abstract: Methods for cleaning industrial tanks are disclosed in which a fast temporary seal is applied to a manway entry into a tank to be cleaned. A robotic tank cleaning system is introduced through the temporary seal into the tank. The tank interior is sprayed with diluent to remove liquid and solid volatile organic compound (VOC) generating residue. VOC's are removed from the tank by repetitive diesel and water/surfactant fogging until a safe, legal level of VOC's remains in the tank atmosphere.