Abstract: A computer tagging system and computer-implemented method for programming a programmable component configured to be embedded in an animal, with user specified information relating to identification of the animal, in a second memory portion that is programmable to include the user specified information. A console component is communicatively coupled to a user interface and an RFID programming emitter. The console component, via the user interface, receive user entered information prescribing the user specified information relating to identification of the animal. A signal including the user specified information is transmitted from the RFID programming emitter to the programmable component located in proximity the RFID programming emitter. Responsive to receiving the transmitted signal from the RFID programming emitter, the user specified information is caused to be stored in the second memory portion of the programmable component.

Abstract: A computer system and method for identifying and monitoring animals in a confined space. A tracking apparatus is provided in proximity to the confined space that defines a plurality of separate individual tracking regions for the confined space. Each of a plurality of animals to be disposed in the confined space is associated respectively with a detection component operable to identify and detect a temperature of an animal it is associated with when detected by the tracking apparatus. Data is received in a computer monitor system from a detection component when detected by the tracking apparatus in the confined space wherein the received data includes motion and temperature data relating to an animal when located in the confined space. The tracking apparatus detects multiple animals simultaneously located in an individual tracking region.

Abstract: A computer system and method for identifying and monitoring animals in a confined space. A tracking apparatus is provided in proximity to the confined space that defines a plurality of separate individual tracking regions for the confined space. Each of a plurality of animals to be disposed in the confined space is associated respectively with a detection component operable to identify and detect a temperature of an animal it is associated with when detected by the tracking apparatus. Data is received in a computer monitor system from a detection component when detected by the tracking apparatus in the confined space wherein the received data includes motion and temperature data relating to an animal when located in the confined space. The tracking apparatus detects multiple animals simultaneously located in an individual tracking region.

Abstract: Provided are an antibody or antigen binding fragment thereof that binds to CD70 for use in treating a myeloid malignancy in a human subject, who is resistant to BCL-2 inhibitor treatment and methods of treating a myeloid malignancy in a subject, said method comprising (a) selecting a human subject having a myeloid malignancy that has a reduced sensitivity or is refractory to a BCL-2 inhibitor; and (b) administering to the subject an antibody or antigen binding fragment thereof that binds to CD70. In certain embodiments, the myeloid malignancy is acute myeloid leukemia (AML). In certain embodiments, the antibody that binds to CD70 is cusatuzumab. In certain embodiments, a BCL-2 inhibitor is co-administered with the antibody or antigen binding fragment thereof that binds to CD70. In certain embodiments, the BCL-2 inhibitor is venetoclax.

Abstract: An aircraft includes a frame, a transmission, and a liquid inertia vibration elimination (“LIVE”) system coupled between the frame and the transmission. The LIVE system is configured to attenuate communication of vibrations from the transmission to the frame. The LIVE system includes a first liquid zone, a second liquid zone, a plug at least partially segregating the first liquid zone from the second liquid zone, and the plug has an aperture in fluid communication with the first liquid zone and the second liquid zone. A splash guard is disposed within the second liquid zone and offset from the plug.

Abstract: A system and method for identifying and monitoring passage of a plurality of animals in a passageway. The system includes a computer monitoring device having a processor and memory, and a detection device, communicatively coupled to the computer monitoring device. The detection device is positioned in proximity to an animal passageway. The detection device includes an antenna element configured to detect identification data from a respective detection component respectively associated with each of the plurality animals when located in close proximity to the passageway. The detected identification data includes a unique ID associated with the animal wherein each detection component consists of a capsule device configured to be located internal of an animal.

Abstract: A computer system and method for identifying and monitoring animals in a confined space. A tracking apparatus is provided in proximity to the confined space that defines a plurality of separate individual tracking regions for the confined space. Each of a plurality of animals to be disposed in the confined space is associated respectively with a detection component operable to identify and detect a temperature of an animal it is associated with when detected by the tracking apparatus. Data is received in a computer monitor system from a detection component when detected by the tracking apparatus in the confined space wherein the received data includes motion and temperature data relating to an animal when located in the confined space. The tracking apparatus detects multiple animals simultaneously located in an individual tracking region.

Abstract: A computer system and method for identifying and monitoring animals in a confined space. A tracking apparatus is provided having a plurality of antenna arrays in proximity to a confined space. One or more animals to be disposed in the confined space are associated with a detection component operable to identify and detect a core body temperature of an animal it is associated with when detected by the tracking apparatus. Data is received in a computer monitor system from a detection component when detected by the tracking apparatus in the confined space. The received data identifies an animal in correlation with its motion and temperature data. Real-time position and core body temperature of a detected animal is determined while the animal is disposed in the confined space by analysis of the received data in the computer monitor system.

Abstract: The present disclosure relates to compounds of Formula (I): stereoisomers thereof, prodrugs thereof, and pharmaceutically acceptable salts thereof. The present disclosure also relates to uses of the compounds, e.g., to inhibit AMP-Activated protein kinase (AMPK) and treat cancer in a subject.

Abstract: A system for integrating at least one object with an animal within a research facility comprises at least one animal within the research facility, the at least one animal having a first tag associated therewith that is configured to communicate with a data management system. The system further includes at least one laboratory object having a second tag associated therewith and being associated with the at least one animal, the second tag being configured to communicate with the data management system. Still further, the system includes at least one technician badge having a third tag associated therewith, the badge configured to communicate with the data management system. The at least one animal, the at least one laboratory object, and the at least one technician badge are configured to transmit information to the data management system.

Abstract: A computer system and method for identifying and monitoring animals in a confined space. A tracking apparatus is provided having a plurality of antenna arrays in proximity to a confined space. One or more animals to be disposed in the confined space are associated with a detection component operable to identify and detect a core body temperature of an animal it is associated with when detected by the tracking apparatus. Data is received in a computer monitor system from a detection component when detected by the tracking apparatus in the confined space. The received data identifies an animal in correlation with its motion and temperature data. Real-time position and core body temperature of a detected animal is determined while the animal is disposed in the confined space by analysis of the received data in the computer monitor system.

Abstract: The present disclosure relates to compositions and methods for reducing cancer stem cells. In some aspects, the compositions and methods can comprise at least one metabolism modulating agent. In other aspects, the compositions and methods can comprise at least two metabolism modulating agents.

Abstract: A computer system and method for identifying and monitoring animals in a confined space. A tracking apparatus is provided having a plurality of antenna arrays in proximity to a confined space. One or more animals to be disposed in the confined space are associated with a detection component operable to identify and detect a core body temperature of an animal it is associated with when detected by the tracking apparatus. Data is received in a computer monitor system from a detection component when detected by the tracking apparatus in the confined space. The received data identifies an animal in correlation with its motion and temperature data. Real-time position and core body temperature of a detected animal is determined while the animal is disposed in the confined space by analysis of the received data in the computer monitor system.

Abstract: A computer system and method for identifying and monitoring animals in a confined space. A tracking apparatus is provided having a plurality of antenna arrays in proximity to a confined space. One or more animals to be disposed in the confined space are associated with a detection component operable to identify and detect a core body temperature of an animal it is associated with when detected by the tracking apparatus. Data is received in a computer monitor system from a detection component when detected by the tracking apparatus in the confined space. The received data identifies an animal in correlation with its motion and temperature data. Real-time position and core body temperature of a detected animal is determined while the animal is disposed in the confined space by analysis of the received data in the computer monitor system.

Abstract: Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3R? or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful for selectively binding to CD123 and impairing progenitor hematologic cancer cells. These compounds may include cytotoxic moieties such as, for example, radioisotopes or chemotherapeutics.

Abstract: Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3R? or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful for selectively binding to CD123 and impairing progenitor hematologic cancer cells. These compounds may include cytotoxic moieties such as, for example, radioisotopes or chemotherapeutics.

Abstract: The present disclosure relates to triazole derivatives of melampomagnolide B, their synthesis, and their use as anti-cancer compounds.

Abstract: The present disclosure relates to triazole derivatives of melampomagnolide B, their synthesis, and their use as anti-cancer compounds.

Abstract: The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).

Abstract: The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).