Patents by Inventor Craig L. Duvall

Craig L. Duvall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220241317
    Abstract: Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
    Type: Application
    Filed: September 14, 2021
    Publication date: August 4, 2022
    Inventors: Craig L. Duvall, Samantha M. Sarett, Thomas A. Werfel
  • Publication number: 20220195500
    Abstract: The present disclosure relates to probes and methods for detecting nucleic acids, and for detecting and treating neovas-cularization.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 23, 2022
    Inventors: Imam UDDIN, John S. PENN, Craig L. DUVALL
  • Patent number: 11147827
    Abstract: Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: October 19, 2021
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, Samantha M. Sarett, Thomas A. Werfel
  • Publication number: 20200323785
    Abstract: A polymeric nanocarrier and method of treating a bone disease are provided. The polymeric nanocarrier includes an amphiphilic copolymer including a hydrophobic block and a hydrophilic block, where the hydrophilic block comprises a random copolymer. The method of treating a bone disease includes administering the polymeric nanocarrier to a subject in need thereof.
    Type: Application
    Filed: April 9, 2020
    Publication date: October 15, 2020
    Inventors: Craig L Duvall, Joseph Paul Vanderburgh, Mukesh K. Gupta, Scott A. Guelcher, Julie A. Rhoades
  • Publication number: 20200247930
    Abstract: Provided herein are a reactive oxygen species (ROS) scavenging composition, a method of forming a ROS scavenging composition, and a method of treating a subject having a (ROS) perpetuated disease. The ROS scavenging composition includes a co-polymer of a hydrophilic monomer and a grafting monomer, and a ROS scavenging compound grafted to the grafting monomer. The method of forming a ROS scavenging composition includes forming a co-polymer of a hydrophilic monomer and a grafting monomer, and grafting ROS scavenging compound onto the co-polymer. The method of treating a subject having a ROS perpetuated disease includes administering a therapeutically effective amount of an ROS scavenging composition comprising a co-polymer of a hydrophilic monomer and a grafting monomer, and a ROS scavenging compound grafted to the grafting monomer, to the subject in need thereof.
    Type: Application
    Filed: October 1, 2018
    Publication date: August 6, 2020
    Inventors: Craig L. Duvall, Taylor Kavanaugh, Eric Dailing, Bryan Dollinger, Carlisle Dejulius
  • Patent number: 10695288
    Abstract: A reactive oxygen species savaging emulsion; the emulsion comprising an injectable pharmaceutically acceptable composition and a polymeric poly(propylene sulfide) microsphere for targeted delivery to a site with elevated reactive oxygen species. In embodiments of the present invention, the microsphere is loaded with a biologically active agent.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: June 30, 2020
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, John R. Martin, Kristin P. O'Grady, Christopher E. Nelson
  • Publication number: 20200171169
    Abstract: Provided herein are a polymer, a polyplex, and a method of treating a disease. The polymer includes a core-forming block and a zwitterionic corona block. The polyplex includes the polymer complexed with an active agent. The method of treating a disease comprises administering the polyplex to a subject in need thereof.
    Type: Application
    Filed: May 15, 2018
    Publication date: June 4, 2020
    Inventors: Craig L. Duvall, Meredith A. Jackson
  • Publication number: 20200147121
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
    Type: Application
    Filed: September 23, 2019
    Publication date: May 14, 2020
    Applicants: University of Washington, GENEVANT SCIENCES GMBH
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20200054755
    Abstract: The presently-disclosed subject matter includes a polymer (i.e., copolymer) comprising a thermally responsive block and a hydrophobic block. In some embodiments the copolymer is a terpolymer. Specific embodiments include a thermo-responsive, ROS degradable ABC triblock terpolymer comprising poly(propylenesulfide)-block-poly(N,N-dimethylacrylamide)-block-poly(N-isopropylacrylamide) (PPS-b-PDMA-b-PNIPAAM).
    Type: Application
    Filed: August 21, 2019
    Publication date: February 20, 2020
    Inventors: Craig L. Duvall, Mukesh K Gupta, John R. Martin, Bryan R. Dollinger
  • Patent number: 10512607
    Abstract: Embodiments of the present disclosure include particles, methods of making particles, methods of delivering an active agent using the particle, and the like.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: December 24, 2019
    Assignees: Vanderbilt University, University of Florida Research Foundation, Inc.
    Inventors: Benjamin G. Keselowsky, Jamal Lewis, Lawrence Premasiri Fernando, Craig L. Duvall, Brian C. Evans, Lirong Yang
  • Patent number: 10420790
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: September 24, 2019
    Assignees: University of Washington, GENEVANT SCIENCES GMBH
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
  • Patent number: 10172956
    Abstract: The presently-disclosed subject matter includes nanoparticles that comprise a plurality of assembled polymers. In some embodiments the polymers comprise a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle, and a second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle. In some embodiments a polynucleotide is provided that is bound to the cationic monomers of the nanoparticle. The presently-disclosed subject matter also comprises methods for using the present nanoparticles to include RNAi in a cell as well as methods for making the present nanoparticles.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: January 8, 2019
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, Christopher E. Nelson, James Kintzing, Joshua M. Shannon, Mukesh K. Gupta, Scott A. Guelcher, Elizabeth J. Adolph, Jeffrey M. Davidson
  • Patent number: 10105455
    Abstract: Disclosed are compositions that comprise a cyclooxygenase-2-selective therapeutic and/or diagnostic agent having a therapeutic and/or diagnostic agent conjugated to a NSAID drug; and a ROS-responsive nanoparticle. Methods of making and using these compositions for drug encapsulation and delivery are also disclosed.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: October 23, 2018
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, Lawrence J. Marnett, Jashim Uddin, Thomas A. Werfel, Mukesh Gupta, Brenda C. Crews
  • Publication number: 20180280568
    Abstract: A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups.
    Type: Application
    Filed: October 14, 2016
    Publication date: October 4, 2018
    Inventors: Scott A. Guelcher, Madison A.P. McEnery, Mukesh K. Gupta, Craig L. Duvall
  • Patent number: 10046086
    Abstract: A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: August 14, 2018
    Assignee: Vanderbilt University
    Inventors: Scott A. Guelcher, Madison McGough, Mukesh K. Gupta, Craig L. Duvall, John Martin, Jon Page
  • Publication number: 20180171056
    Abstract: Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
    Type: Application
    Filed: November 30, 2017
    Publication date: June 21, 2018
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Danielle Benoit, Craig L. Duvall, Paul H. Johnson, Anna S. Gall
  • Publication number: 20180064749
    Abstract: Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
    Type: Application
    Filed: August 7, 2017
    Publication date: March 8, 2018
    Inventors: Craig L. Duvall, Samantha M. Sarett, Thomas A. Werfel
  • Patent number: 9862792
    Abstract: Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: January 9, 2018
    Assignees: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Danielle Benoit, Craig L. Duvall, Paul H. Johnson, Anna S. Gall
  • Publication number: 20170239360
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 24, 2017
    Applicants: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Patent number: 9662403
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: May 30, 2017
    Assignees: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De