Patents by Inventor Craig L. Duvall

Craig L. Duvall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250099497
    Abstract: Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
    Type: Application
    Filed: December 9, 2024
    Publication date: March 27, 2025
    Inventors: Craig L. Duvall, Samantha M. Sarett, Thomas A. Werfel
  • Publication number: 20250041571
    Abstract: Disclosed herein are drug coated medical devices that can be used for the treatment of vascular diseases. An example device includes a medical device having an outer surface, and a multi-layer drug coating on the outer surface, the multi-layer drug coating including at least one polycationic layer including a cationic therapeutic and at least one polyanionic layer including an anionic polymer. Also disclosed are methods of making the drug coated medical devices and methods of treating vascular diseases.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 6, 2025
    Inventors: Craig L. Duvall, John W. Tierney
  • Patent number: 12201644
    Abstract: Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: January 21, 2025
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, Samantha M. Sarett, Thomas A. Werfel
  • Publication number: 20240409938
    Abstract: Disclosed herein are methods of treating central nervous system diseases, such as Alzheimer's disease and Huntington's disease, using lipophilic siRNA conjugates that can bind to albumin. The disclosed methods can advantageously provide widespread, long-term gene silencing in the central nervous system. An example method includes administering to a subject an effective amount of a conjugate, optionally in combination with a pharmaceutically acceptable excipient, wherein the conjugate includes a siRNA capable of inhibiting expression of a protein associated with the central nervous system disease; a lipophilic ligand capable of binding albumin; and a linker attaching the siRNA to the lipophilic ligand, the linker including a branching molecule attached to the siRNA, and a hydrophilic spacer attaching the branching molecule to the lipophilic ligand.
    Type: Application
    Filed: June 7, 2024
    Publication date: December 12, 2024
    Inventors: Craig L. Duvall, Ethan S. Lippmann, Alexander G. Sorets
  • Publication number: 20240408027
    Abstract: Disclosed herein arm block copolymers that have beneficial drug loading properties. An example block copolymer includes a first block that is hydrophilic and a second block having pendant groups that can non-covalently interact with a drug. Also disclosed are particles including self-assembled block copolymers and a drug; and methods of treating diseases.
    Type: Application
    Filed: October 6, 2022
    Publication date: December 12, 2024
    Inventors: Craig L. Duvall, Richard d'Arcy, Patrick Gerber, Marcus Bernard
  • Publication number: 20240271130
    Abstract: Disclosed herein are methods of treating inflammatory diseases, such as arthritis or traumatic injury, using lipophilic siRNA conjugates that can bind to albumin. An example method includes administering to a subject an effective amount of a conjugate, optionally in combination with a pharmaceutically acceptable excipient, wherein the conjugate includes a siRNA capable of inhibiting expression of a protein associated with the inflammatory disease; a lipophilic ligand capable of binding albumin; and a linker attaching the siRNA to the lipophilic ligand, the linker including a branching molecule attached to the siRNA, and a hydrophilic spacer attaching the branching molecule to the lipophilic ligand.
    Type: Application
    Filed: March 1, 2023
    Publication date: August 15, 2024
    Inventors: Craig L. Duvall, Juan M. Colazo
  • Publication number: 20240226372
    Abstract: The presently-disclosed subject matter includes hydrophilic thioketal polymers and scaffolds formed therefrom.
    Type: Application
    Filed: April 21, 2022
    Publication date: July 11, 2024
    Inventors: Craig L. Duvall, Prarthana Patil, Mukesh K Gupta, Joshua Tyler McCune, Richard d'Arcy
  • Publication number: 20230295262
    Abstract: The disclosure describes engineered cells for the treatment of joint and bone disease. The cells are engineered to sense signals only found in diseased compartments and in turn produce therapeutic molecules that are secreted into the local environment.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 21, 2023
    Applicants: Vanderbilt University, University of Tennessee Research Foundation
    Inventors: Jonathan M. Brunger, Karen A. Hasty, Bonnie L. Walton, Craig L. Duvall
  • Patent number: 11707483
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: July 25, 2023
    Assignees: UNIVERSITY OF WASHINGTON, GENEVANT SCIENCES GMBH
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20220241317
    Abstract: Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
    Type: Application
    Filed: September 14, 2021
    Publication date: August 4, 2022
    Inventors: Craig L. Duvall, Samantha M. Sarett, Thomas A. Werfel
  • Publication number: 20220195500
    Abstract: The present disclosure relates to probes and methods for detecting nucleic acids, and for detecting and treating neovas-cularization.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 23, 2022
    Inventors: Imam UDDIN, John S. PENN, Craig L. DUVALL
  • Patent number: 11147827
    Abstract: Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: October 19, 2021
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, Samantha M. Sarett, Thomas A. Werfel
  • Publication number: 20200323785
    Abstract: A polymeric nanocarrier and method of treating a bone disease are provided. The polymeric nanocarrier includes an amphiphilic copolymer including a hydrophobic block and a hydrophilic block, where the hydrophilic block comprises a random copolymer. The method of treating a bone disease includes administering the polymeric nanocarrier to a subject in need thereof.
    Type: Application
    Filed: April 9, 2020
    Publication date: October 15, 2020
    Inventors: Craig L Duvall, Joseph Paul Vanderburgh, Mukesh K. Gupta, Scott A. Guelcher, Julie A. Rhoades
  • Publication number: 20200247930
    Abstract: Provided herein are a reactive oxygen species (ROS) scavenging composition, a method of forming a ROS scavenging composition, and a method of treating a subject having a (ROS) perpetuated disease. The ROS scavenging composition includes a co-polymer of a hydrophilic monomer and a grafting monomer, and a ROS scavenging compound grafted to the grafting monomer. The method of forming a ROS scavenging composition includes forming a co-polymer of a hydrophilic monomer and a grafting monomer, and grafting ROS scavenging compound onto the co-polymer. The method of treating a subject having a ROS perpetuated disease includes administering a therapeutically effective amount of an ROS scavenging composition comprising a co-polymer of a hydrophilic monomer and a grafting monomer, and a ROS scavenging compound grafted to the grafting monomer, to the subject in need thereof.
    Type: Application
    Filed: October 1, 2018
    Publication date: August 6, 2020
    Inventors: Craig L. Duvall, Taylor Kavanaugh, Eric Dailing, Bryan Dollinger, Carlisle Dejulius
  • Patent number: 10695288
    Abstract: A reactive oxygen species savaging emulsion; the emulsion comprising an injectable pharmaceutically acceptable composition and a polymeric poly(propylene sulfide) microsphere for targeted delivery to a site with elevated reactive oxygen species. In embodiments of the present invention, the microsphere is loaded with a biologically active agent.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: June 30, 2020
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, John R. Martin, Kristin P. O'Grady, Christopher E. Nelson
  • Publication number: 20200171169
    Abstract: Provided herein are a polymer, a polyplex, and a method of treating a disease. The polymer includes a core-forming block and a zwitterionic corona block. The polyplex includes the polymer complexed with an active agent. The method of treating a disease comprises administering the polyplex to a subject in need thereof.
    Type: Application
    Filed: May 15, 2018
    Publication date: June 4, 2020
    Inventors: Craig L. Duvall, Meredith A. Jackson
  • Publication number: 20200147121
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
    Type: Application
    Filed: September 23, 2019
    Publication date: May 14, 2020
    Applicants: University of Washington, GENEVANT SCIENCES GMBH
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20200054755
    Abstract: The presently-disclosed subject matter includes a polymer (i.e., copolymer) comprising a thermally responsive block and a hydrophobic block. In some embodiments the copolymer is a terpolymer. Specific embodiments include a thermo-responsive, ROS degradable ABC triblock terpolymer comprising poly(propylenesulfide)-block-poly(N,N-dimethylacrylamide)-block-poly(N-isopropylacrylamide) (PPS-b-PDMA-b-PNIPAAM).
    Type: Application
    Filed: August 21, 2019
    Publication date: February 20, 2020
    Inventors: Craig L. Duvall, Mukesh K Gupta, John R. Martin, Bryan R. Dollinger
  • Patent number: 10512607
    Abstract: Embodiments of the present disclosure include particles, methods of making particles, methods of delivering an active agent using the particle, and the like.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: December 24, 2019
    Assignees: Vanderbilt University, University of Florida Research Foundation, Inc.
    Inventors: Benjamin G. Keselowsky, Jamal Lewis, Lawrence Premasiri Fernando, Craig L. Duvall, Brian C. Evans, Lirong Yang
  • Patent number: 10420790
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: September 24, 2019
    Assignees: University of Washington, GENEVANT SCIENCES GMBH
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De