Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A railing system for stairs comprises a plurality of pickets, a first rail, and a second rail. The first rail comprises a handle portion, an attachment portion, and a first cover. The attachment portion is attached to the pickets using fasteners. The first cover is adapted to cover the fasteners when the attachment portion is attached to the pickets. The second rail comprises a base member, a base sidewall, and a second cover. The base member comprises a plurality of base openings adapted to receive the pickets. The base sidewall is attached to the pickets using fasteners. The second cover is adapted to fit over the fasteners when base sidewall is attached to the pickets.

Abstract: An apparatus is provided for rotatable selection of sites for cannulation with a needle along a subcutaneous vascular access vessel. The cannulation site selection apparatus comprises a template having an inner surface and an outer surface, and a plurality of visible markings on the outer surface of the template. The template is adapted to be disposed adjacent the subcutaneous vascular access vessel such that the markings align with the cannulation sites along the vascular access vessel for selecting a site for cannulation with a needle into the vascular access vessel.

Abstract: A method for rotatable selection of sites for cannulation of a subcutaneous vascular access vessel comprises the step of providing a template defining an opening for a plurality of zones, each of the plurality of zones configured for receiving a plurality of simultaneous cannulations accessing the vascular access vessel. The outer surface of the template is marked, the marking defining each of the plurality of zones for use as cannulation sites along the vascular access vessel. The template is positioned on the skin of the patient adjacent the subcutaneous vascular access vessel such that the opening aligns with the vascular access vessel, and the marking is used for selecting a first zone for a cannulation site into the vascular access vessel such that the cannulation site in the first zone is spaced from and not adjacent to a second zone used for cannulation immediately previously to the first zone.

Abstract: A corner member for a screen door comprises opposed inner and outer surfaces and first and second connectors extending between the inner and outer surfaces. The corner member further comprises a first protrusion extending from the first connector and a second protrusion extending from the second connector. The corner member further comprises a wheel guide, an adjustment mechanism, and a third connector. The wheel guide extends from the second protrusion. The wheel mechanism is pivotably connected to the wheel guide. The adjustment mechanism adjustably pivots the wheel mechanism with respect to the wheel guide. The third connector extends between the inner and outer surfaces. The inner surface, the outer surface, the first connector, the second connector, and the third connector define, at least in part, a corner cavity. The third connector comprises an opening that provides access through the corner cavity to the adjustment mechanism.

Abstract: In some examples, a computing device creates an event log when an event occurs. If the event log includes a path comprising one or more components, the computing device may determine a hash, using a hash function and a salt, for each of the components and substitute each component in the path with an index to the hash stored in a dictionary. In this way, the computing device replaces each component of the path with an index to a hash in the dictionary to create a modified path. The resulting modified path can be traversed and searched. For example, a search term may be hashed using the hash function and salt, and the dictionary associated with the logs searched for a match. In this way, a particular file name or a particular folder name can be identified in the modified path.

Abstract: An electrical terminal includes a body with a first opening for receiving an electrical conductor and a second opening for coupling the electrical terminal to an electrically conducting member. The second opening has a first open portion with an inner dimension to receive a first fastener and a second open portion with an inner dimension different than the first open portion. The second open portion is configured to receive a second fastener having an outer dimension different than the first fastener. The second open portion can have a substantially circular first and second open portions that overlap along the outer edges. An electrical assembly includes the electrical terminal and an electrically conducting base, and either a first fastener having a first dimension or a second fastener having a second dimension, where the dimension of the fasteners corresponding to dimension of a threaded hole in the base.

Abstract: A system for facilitating construction of a deck comprises a server, a client computer, and a database. A user inputs, through a graphical user interface on the display of the client computer, a configuration for the deck. The server receives the deck information from the client computer and determines, based on information in the database and the deck information, a parts list and instruction information. The instruction information includes information on the alterations to the parts needed to construct the deck. The parts list and the instruction information may be displayed on the user interface.

Abstract: A modular fencing system comprises two or more substantially vertical posts, one or more panels, and one or more track members. Each of the posts comprises abase and an upright member extending from the base. The upright member comprises a plurality of surfaces, and at least one of the surfaces defines a channel. Each of the track members comprises an attachment portion configured to engage within the channel and a receiving portion configured to engage with one or more of the panels.

Abstract: A railing system comprises first and second rails, a post, a first bracket and a second bracket. The first bracket connects the first rail to the post and comprises a first plate, a first pivot member, a first receiving portion, and a first base. The first receiving portion and the first base are adapted to pivot about a longitudinal axis of the first pivot member. The second bracket connects the second rail to the post, and comprises a second plate, a second pivot member, a second receiving portion, and a pin. The second receiving portion is adapted to pivot about a longitudinal axis of the second pivot member.

Abstract: A pulforming system for forming a three-dimensional article includes a plurality of fibers, a resin injection system, resin, a preform die, a movable first pulling sled, a movable second pulling sled and a cutting station. The first and second pulling sleds form the fibers and resin into an article using a sequential, continual movement process of back-and-forth translational motion in unison to form an article that is three-dimensional in one or more of a longitudinal or transverse direction.

Abstract: A bracket for connecting a stair rail to a post comprises a base and a cover adapted to slide over the base. The base comprises a plate and two opposed sidewalls. The plate has first and second surfaces. The sidewalls extend from the first surface of the plate. Two plate protrusions are formed on the second surface of the plate, with the two plate protrusions extending for at least a portion of a height of the plate. The cover comprises a roof, two opposed cover walls extending from the roof, and two flanges. Each of the cover walls comprise a cover wall edge, with each of the flanges extend from the cover wall edge for at least a portion of a height of the cover wall. The flanges are adapted to engage with the plate protrusions when the cover is slid over the base.

Abstract: A railing system for stairs comprises a plurality of pickets, a first rail, and a second rail. The first rail comprises a handle portion, an attachment portion, and a first cover. The attachment portion is attached to the pickets using fasteners. The first cover is adapted to cover the fasteners when the attachment portion is attached to the pickets. The second rail comprises a base member, a base sidewall, and a second cover. The base member comprises a plurality of base openings adapted to receive the pickets. The base sidewall is attached to the pickets using fasteners. The second cover is adapted to fit over the fasteners when base sidewall is attached to the pickets.

Abstract: A standing hook comprises a substantially hollow upright member, a cap, a support member, and a hook portion. The upright member comprises first and second ends, with the second end being configured to be inserted into the ground. The cap is attached to, and covers, the first end. The support member is rigidly attached to the upright member between the first and second ends. The hook portion extends from the upright member and comprises one or more structural portions. At least one of the structural portions comprises a hook for supporting one or more objects. The hook portion is substantially solid.

Abstract: A rail for a railing system with pickets comprises an elongated cover portion and an elongated side portion. The cover portion comprises an elongated top surface, one or more first connectors proximate to a lateral end of the top surface, a plurality of shelves interspersed between successive ones of the pickets, and one or more second connectors. Each of the shelves comprises a first end, and each of the second connectors extends from at least some of the first ends. The elongated side portion comprises one or more third connectors and one or more fourth connectors. The third connectors are adapted to engage with the one or more first connectors, and the fourth connectors are adapted to engage with the one or more second connectors. The side portion is secured to the cover portion by engagement of the third connectors with the first connectors and by engagement of the fourth connectors with the second connectors.

Abstract: A standing hook comprises a substantially hollow upright member, a cap, a support member, and a hook portion. The upright member comprises first and second ends, with the second end being configured to be inserted into the ground. The cap is attached to, and covers, the first end. The support member is rigidly attached to the upright member between the first and second ends. The hook portion extends from the upright member and comprises one or more structural portions. At least one of the structural portions comprises a hook for supporting one or more objects. The hook portion is substantially solid.

Abstract: A system for facilitating construction of a deck comprises a server, a client computer, and a database. A user inputs, through a graphical user interface on the display of the client computer, a configuration for the deck. The server receives the deck information from the client computer and determines, based on information in the database and the deck information, a parts list and instruction information. The instruction information includes information on the alterations to the parts needed to construct the deck. The parts list and the instruction information may be displayed on the user interface.