Patents by Inventor Craig Leach

Craig Leach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136722
    Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.
    Type: Application
    Filed: August 12, 2022
    Publication date: May 1, 2025
    Inventors: Peiling CHEN, Michael Gerard DARCY, Jason W. DODSON, Beth A. KNAPP-REED, Craig LEACH, Yuehu LI, Andrew Peter MARCUS, Joseph Paul MARINO, Jeffrey Alan OPLINGER, James P. PHELAN, Matthew Robert SENDER, Brandon TURUNEN, Guosen YE, Cunyu ZHANG, Jae U. JEONG
  • Publication number: 20240325392
    Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.
    Type: Application
    Filed: February 9, 2024
    Publication date: October 3, 2024
    Inventors: Peiling CHEN, Jason W. DODSON, Beth A. KNAPP-REED, Craig LEACH, Yuehu LI, Joseph Paul MARINO, JR., Matthew Robert SENDER, Brandon TURUNEN, Guosen YE, Cunyu ZHANG
  • Publication number: 20210379044
    Abstract: The present invention relates to non peptidic, heterobivalent molecules (HBM) that are able to simultaneously bind a surface target protein as well as an endogenous or exogenous human antibody protein and induce immune effector function. More specifically, the present invention relates to agents capable of binding to a chemokine receptor and inducing the depletion of chemokine receptor positive subsets of pathogenic cells in a subject for use in the treatment and/or prevention of cancer, inflammatory, autoimmune and allergic disease.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 9, 2021
    Inventors: James BAILEY, Yao CHEN, Mark HURLE, Craig LEACH, Brandon TURUNEN
  • Publication number: 20190336489
    Abstract: The present invention relates to non peptidic, heterobivalent molecules (HBM) that are able to simultaneously bind a surface target protein as well as an endogenous or exogenous human antibody protein and induce immune effector function. More specifically, the present invention relates to agents capable of binding to a chemokine receptor and inducing the depletion of chemokine receptor positive subsets of pathogenic cells in a subject for use in the treatment and/or prevention of cancer, inflammatory, autoimmune and allergic disease.
    Type: Application
    Filed: January 16, 2018
    Publication date: November 7, 2019
    Inventors: James BAILEY, Yao CHEN, Mark HURLE, Craig LEACH, Brandon TURUNEN
  • Patent number: 10292362
    Abstract: An animal feeding device comprising a body having a first opening in a first end thereof and a second opening in a second end thereof, the body being in the form of a channel having a substantially C-, U- or V-shape in cross section and comprising a passageway extending between the first opening and the second opening, the body further comprising one or more bends therein such that the first opening and the second opening are provided in different orientations to one another, and wherein the body is adapted to substantially preclude the accumulation of animal feed on an inner surface of the passageway during use, and wherein in use an open portion of the channel is located so as to abut an inner surface of a receptacle in which animal feed is housed.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: May 21, 2019
    Inventor: Craig Leach
  • Publication number: 20180042201
    Abstract: An animal feeding device comprising a body having a first opening in a first end thereof and a second opening in a second end thereof, the body being in the form of a channel having a substantially C-, U- or V-shape in cross section and comprising a passageway extending between the first opening and the second opening, the body further comprising one or more bends therein such that the first opening and the second opening are provided in different orientations to one another, and wherein the body is adapted to substantially preclude the accumulation of animal feed on an inner surface of the passageway during use, and wherein in use an open portion of the channel is located so as to abut an inner surface of a receptacle in which animal feed is housed.
    Type: Application
    Filed: March 9, 2016
    Publication date: February 15, 2018
    Inventor: Craig Leach
  • Patent number: 9521879
    Abstract: A removable stud or cleat assembly for footwear is provided, particularly for athletic or sports footwear. The stud or cleat assembly includes a stud having a first and second mounting structure and engagement structure located on the sole of the footwear and configured for engaging the first and second mounting structure of the stud. Engagement of the stud is achieved by aligning the first mounting structure relative to the engagement structure, temporarily deforming the second mounting structure and rotating the stud relative to the engagement structure to thereby securely engage the first and second mounting structure with the engagement structure. Disengagement of the stud from the engagement structure is achieved by biasing the second mounting structure to disengage the second mounting structure from the engagement structure and rotating the stud relative to the engagement structure to thereby disengage the first mounting structure.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: December 20, 2016
    Assignee: RAPTOR SPORTS PTY LTD
    Inventor: Craig Leach
  • Patent number: 9382574
    Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: July 5, 2016
    Assignee: Lifesensors, Inc.
    Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
  • Publication number: 20150305446
    Abstract: A removable stud or cleat assembly for footwear is provided, particularly for athletic or sports footwear. The stud or cleat assembly includes a stud having a first and second mounting structure and engagement structure located on the sole of the footwear and configured for engaging the first and second mounting structure of the stud. Engagement of the stud is achieved by aligning the first mounting structure relative to the engagement structure, temporarily deforming the second mounting structure and rotating the stud relative to the engagement structure to thereby securely engage the first and second mounting structure with the engagement structure. Disengagement of the stud from the engagement structure is achieved by biasing the second mounting structure to disengage the second mounting structure from the engagement structure and rotating the stud relative to the engagement structure to thereby disengage the first mounting structure.
    Type: Application
    Filed: May 15, 2012
    Publication date: October 29, 2015
    Inventor: Craig Leach
  • Publication number: 20140309141
    Abstract: Methods and compositions for detection of the modulators of proteolytic enzymes, particularly cysteine proteases, are disclosed.
    Type: Application
    Filed: September 21, 2012
    Publication date: October 16, 2014
    Inventors: Craig Leach, James Strickler, Michael Eddins
  • Publication number: 20140072992
    Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.
    Type: Application
    Filed: August 26, 2013
    Publication date: March 13, 2014
    Applicants: Progenra, Inc., Lifesensors, Inc.
    Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
  • Publication number: 20130273027
    Abstract: Mutant enzymes and methods of use thereof are provided.
    Type: Application
    Filed: March 13, 2013
    Publication date: October 17, 2013
    Inventors: Craig Leach, Michael Eddins, David Stemer, Benjamin Nicholson
  • Patent number: 8518660
    Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: August 27, 2013
    Assignees: Lifesensors, Inc., Progenra, Inc.
    Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
  • Patent number: 8302332
    Abstract: A removable spike or cleat assembly for footwear, including a sole, wherein the assembly includes a spike or cleat constructed from an elastically deformable material and including one or more leg members and mounting apparatus adapted to engage with the sole, wherein the spike or cleat is adapted to engage with a projection located on the mounting apparatus, the engagement between the spike or cleat and the projection being achieved by rotating the spike or cleat relative to the projection and at least partially inserting the one or more leg members into one or more apertures located on the mounting apparatus, and wherein the spike or cleat is disengaged from the mounting apparatus by producing an elastic deformation of the one or more leg members.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: November 6, 2012
    Assignee: Raptors Sports Pty Ltd
    Inventor: Craig Leach
  • Publication number: 20120107857
    Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.
    Type: Application
    Filed: June 24, 2011
    Publication date: May 3, 2012
    Inventors: Dattananda Chelur, Michael Eddins, Craig Leach, Steven J. Orcutt, Raymond J. Peroutka, James Strickler, Yilin Yan, Kathryn Longenecker
  • Publication number: 20090307933
    Abstract: A removable spike or cleat assembly for footwear, including a sole, wherein the assembly includes a spike or cleat constructed from an elastically deformable material and including one or more leg members and mounting apparatus adapted to engage with the sole, wherein the spike or cleat is adapted to engage with a projection located on the mounting apparatus, the engagement between the spike or cleat and the projection being achieved by rotating the spike or cleat relative to the projection and at least partially inserting the one or more leg members into one or more apertures located on the mounting apparatus, and wherein the spike or cleat is disengaged from the mounting apparatus by producing an elastic deformation of the one or more leg members.
    Type: Application
    Filed: July 17, 2009
    Publication date: December 17, 2009
    Inventor: Craig Leach