Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: The present invention relates to non peptidic, heterobivalent molecules (HBM) that are able to simultaneously bind a surface target protein as well as an endogenous or exogenous human antibody protein and induce immune effector function. More specifically, the present invention relates to agents capable of binding to a chemokine receptor and inducing the depletion of chemokine receptor positive subsets of pathogenic cells in a subject for use in the treatment and/or prevention of cancer, inflammatory, autoimmune and allergic disease.

Abstract: The present invention relates to non peptidic, heterobivalent molecules (HBM) that are able to simultaneously bind a surface target protein as well as an endogenous or exogenous human antibody protein and induce immune effector function. More specifically, the present invention relates to agents capable of binding to a chemokine receptor and inducing the depletion of chemokine receptor positive subsets of pathogenic cells in a subject for use in the treatment and/or prevention of cancer, inflammatory, autoimmune and allergic disease.

Abstract: An animal feeding device comprising a body having a first opening in a first end thereof and a second opening in a second end thereof, the body being in the form of a channel having a substantially C-, U- or V-shape in cross section and comprising a passageway extending between the first opening and the second opening, the body further comprising one or more bends therein such that the first opening and the second opening are provided in different orientations to one another, and wherein the body is adapted to substantially preclude the accumulation of animal feed on an inner surface of the passageway during use, and wherein in use an open portion of the channel is located so as to abut an inner surface of a receptacle in which animal feed is housed.

Abstract: An animal feeding device comprising a body having a first opening in a first end thereof and a second opening in a second end thereof, the body being in the form of a channel having a substantially C-, U- or V-shape in cross section and comprising a passageway extending between the first opening and the second opening, the body further comprising one or more bends therein such that the first opening and the second opening are provided in different orientations to one another, and wherein the body is adapted to substantially preclude the accumulation of animal feed on an inner surface of the passageway during use, and wherein in use an open portion of the channel is located so as to abut an inner surface of a receptacle in which animal feed is housed.

Abstract: A removable stud or cleat assembly for footwear is provided, particularly for athletic or sports footwear. The stud or cleat assembly includes a stud having a first and second mounting structure and engagement structure located on the sole of the footwear and configured for engaging the first and second mounting structure of the stud. Engagement of the stud is achieved by aligning the first mounting structure relative to the engagement structure, temporarily deforming the second mounting structure and rotating the stud relative to the engagement structure to thereby securely engage the first and second mounting structure with the engagement structure. Disengagement of the stud from the engagement structure is achieved by biasing the second mounting structure to disengage the second mounting structure from the engagement structure and rotating the stud relative to the engagement structure to thereby disengage the first mounting structure.

Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.

Abstract: A removable stud or cleat assembly for footwear is provided, particularly for athletic or sports footwear. The stud or cleat assembly includes a stud having a first and second mounting structure and engagement structure located on the sole of the footwear and configured for engaging the first and second mounting structure of the stud. Engagement of the stud is achieved by aligning the first mounting structure relative to the engagement structure, temporarily deforming the second mounting structure and rotating the stud relative to the engagement structure to thereby securely engage the first and second mounting structure with the engagement structure. Disengagement of the stud from the engagement structure is achieved by biasing the second mounting structure to disengage the second mounting structure from the engagement structure and rotating the stud relative to the engagement structure to thereby disengage the first mounting structure.

Abstract: Methods and compositions for detection of the modulators of proteolytic enzymes, particularly cysteine proteases, are disclosed.

Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.

Abstract: Mutant enzymes and methods of use thereof are provided.

Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.

Abstract: A removable spike or cleat assembly for footwear, including a sole, wherein the assembly includes a spike or cleat constructed from an elastically deformable material and including one or more leg members and mounting apparatus adapted to engage with the sole, wherein the spike or cleat is adapted to engage with a projection located on the mounting apparatus, the engagement between the spike or cleat and the projection being achieved by rotating the spike or cleat relative to the projection and at least partially inserting the one or more leg members into one or more apertures located on the mounting apparatus, and wherein the spike or cleat is disengaged from the mounting apparatus by producing an elastic deformation of the one or more leg members.

Abstract: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.

Abstract: A removable spike or cleat assembly for footwear, including a sole, wherein the assembly includes a spike or cleat constructed from an elastically deformable material and including one or more leg members and mounting apparatus adapted to engage with the sole, wherein the spike or cleat is adapted to engage with a projection located on the mounting apparatus, the engagement between the spike or cleat and the projection being achieved by rotating the spike or cleat relative to the projection and at least partially inserting the one or more leg members into one or more apertures located on the mounting apparatus, and wherein the spike or cleat is disengaged from the mounting apparatus by producing an elastic deformation of the one or more leg members.