Abstract: A system for delivering a fluid to a target site of a patient's vasculature having a catheter having a proximal end, a distal end, and a lumen defined by an interior surface of the catheter extending longitudinally through the catheter between the proximal end and the distal end, a guiding element having a distal end, a proximal end, and an exterior surface, the guiding element positioned in the lumen creating an area, between the exterior surface of the guiding element and the interior surface of the catheter, having an effective cross-sectional area sized fluid communication while the guiding element is in the lumen. Also, a method of performing a neurovascular procedure includes providing a multi-catheter assembly including an access catheter, a guide catheter, and a procedure catheter, coupling the assembly to a robotic drive system, and injecting contrast media into the assembly without removing a guiding element.

Abstract: A system for performing a vascular procedure includes a robotic drive system and one or more hub assemblies operatively coupled to the robotic drive system, each of the one or more hub assemblies including a mount, a hub removably coupled to the mount, and an interventional device coupled to the hub. For each of the one or more hub assemblies, the mount is configured to be driven by the robotic drive system to drive the interventional device within a vasculature of a patient, the hub is configured to be uncoupled from the mount while the interventional device is positioned within the vasculature of the patient, and the hub is configured to be manually manipulated to navigate the interventional device to a vascular site while the hub is uncoupled from the mount.

Abstract: A method of performing a vascular procedure can include providing a multi-catheter assembly including a first subset of interventional devices and a second subset of interventional devices detachably couplable to the first subset of interventional devices, coupling the first subset of interventional devices to a robotic drive system, robotically driving the multi-catheter assembly to achieve supra-aortic access while the second subset of interventional devices is coupled to the first subset of interventional devices, uncoupling the second subset of interventional devices from the first subset of interventional devices, manually driving the second subset of interventional devices to a procedure site, and performing a vascular procedure using the second subset of interventional devices.

Abstract: An anti-buckling device for an interventional device assembly, includes a telescoping tube having a plurality of concentric telescopically axially extendable and collapsible tube segments each with a proximal end and a distal end. One or more of the plurality of tube segments includes an inner diameter reducing feature configured to reduce an unsupported free length of an interventional device of the interventional device assembly when the interventional device extends through the telescoping tube, the inner diameter reducing feature attached to the distal end of its associated tube segment having a through hole configured to receive the interventional device therethrough.

Abstract: A method for driving an interventional device assembly along a drive table. The method includes axially advancing an extendable member from an end of a main body of a drive table and axially advancing a hub adapter from a first axial position within the main body to a second axial position within the extendable member beyond the end of the main body. The hub adapter is configured to couple to a corresponding hub so that axial movement of the hub adapter drives axial movement of the corresponding hub.

Abstract: A robotic drive system includes a base structure, a drive table coupled with the base structure and configured to rotate between at least a first position in which a longitudinal axis of the drive table is oriented at a first angle relative to a ground surface and a second position in which the longitudinal axis of the drive table is orientated at a second angle relative to the ground surface, the second angle being different from the first angle. An arm is coupled with the base structure and the drive table and is configured to rotate the drive table about an axis perpendicular to the longitudinal axis of the drive table.

Abstract: An anti-buckling device for an interventional device assembly includes a telescoping tube having a plurality of concentric telescopically axially extendable and collapsible tube segments, the plurality of tube segments including an outermost tube segment and one or more inner tube segments. Each of the one or more inner tube segments comprises a first tube section having a first outer diameter and a second tube section having a second outer diameter.

Abstract: A robotic drive system includes a drive table, a shuttle configured to move axially within the drive table, and one or more hub adapters coupled to the shuttle. The one or more hub adapters are configured to move axially along the shuttle. Each of the one or more hub adapters are configured to couple to a corresponding hub so that axial movement of the each of the one or more hub adapters drives axial movement of the corresponding hub. The drive table includes a main body and an extendable member configured to be at least partially received within the main body. The extendable member is extendable from an end of the main body.

Abstract: An interventional device assembly includes a first hub positioned along a drive table, the first hub having a proximal end and a distal end, an interventional device coupled to the first hub and extending distally therefrom, and a telescoping tube having a proximal end and a distal end. The proximal end of the telescoping tube is secured within an interior of the first hub between the proximal end of the first hub and the distal end of the first hub. The distal end of the telescoping tube is configured to secure to a second hub positioned along the drive table or a distal attachment coupled to the drive table. At least a portion of the interventional device extends through the telescoping tube.

Abstract: A robotic drive system includes a drive table having a support surface oriented at an angle relative to a horizontal plane and one or more hub adapters coupled with the drive table. Each of the one or more hub adapters is coupleable with a corresponding hub of one or more hubs. Each hub is couplable with an interventional device of one or more interventional devices. The support surface is positioned between the one or more hub adapters and the corresponding hubs.

Abstract: An anti-buckling device for an interventional device assembly includes a telescoping tube having a proximal end and a distal end, the proximal end of the telescoping tube being coupled to a first hub of an interventional device assembly, and a distal retainer coupled to the distal end of the telescoping tube, the distal retainer being configured to releasably couple to a distal hub attachment at a distal end of the first hub in a first configuration and releasably couple to a second hub of the interventional device assembly positioned distal to the first hub in a second configuration.

Abstract: An anti-buckling device for an interventional device assembly includes a telescoping tube having a plurality of concentric telescopically axially extendable and collapsible tube segments each having a proximal end and a distal end, the plurality of tube segments having an innermost tube segment and one or more outer tube segments, the innermost tube segment being configured to couple to a hub of an interventional device assembly, the telescoping tube being configured to extend distally from the hub. Each of the one or more outer tube segments is coupled to a cap at its proximal end, the cap having a through hole configured to receive an interventional device of the interventional device assembly therethrough and an outer diameter greater than an outer diameter of the outer tube segment to which the cap is coupled.

Abstract: A robotic drive system includes a drive table having a main body and an extendable member configured to be at least partially received within the main body and being extendable from an end of the main body. One or more hub adapters are coupled with the drive table and are configured to couple to a corresponding hub so that axial movement of the one or more hub adapters drives the corresponding hub.

Abstract: A catheter system with integrated fluidics management includes a first elongate, flexible tubular body having a proximal end, a distal end and at least one lumen, a hub on the proximal end of the tubular body, a valve system in communication with the hub, and a first port, a second port, and a third port in communication with the valve system. The valve system is configured to selectively place any one of the first port, the second port and the third port into communication with the lumen while simultaneously blocking the other two ports from communicating with the lumen.

Abstract: A method of achieving supra aortic access includes the steps of providing an assembly including a guidewire, an access catheter and a guide catheter, coaxially moveably assembled into a single multi-catheter assembly, coupling the assembly to a drive system, driving the assembly to an aortic arch, and advancing the access catheter to achieve supra-aortic access to a branch vessel off of the aortic arch.

Abstract: A method of priming an interventional device assembly includes providing the interventional device assembly including a first interventional device coupled to a first hub and a second interventional device coupled to a second hub arranged in a concentric stack, the second interventional device being positioned within a lumen of the first interventional device. The method includes coupling the interventional device assembly to a drive system while arranged in the concentric stack, axially advancing the first interventional device and the first hub relative to the second hub to decrease a depth of insertion of the second interventional device within the lumen of the first interventional device while maintaining a distal end of the second interventional device within the lumen of the first interventional device, and flushing the first interventional device with fluid after decreasing the depth of insertion of the second interventional device within the lumen of the first interventional device.

Abstract: A method of priming an interventional device assembly includes providing the interventional device assembly, the interventional device assembly including a first interventional device and a second interventional device, the second interventional device being positioned within the first interventional device. The method further includes reciprocally moving at least one of the first interventional device and the second interventional device relative to the other of the first interventional device and the second interventional device while flushing a lumen between the first interventional device and the second interventional device with fluid to remove microbubbles from the lumen.

Abstract: A drive system for achieving supra-aortic access and neurovascular treatment site access includes a guidewire hub configured to adjust an axial position and a rotational position of a guidewire, a procedure catheter hub configured to adjust an axial position and a rotational position of a procedure catheter, a guide catheter hub configured to adjust an axial position of a guide catheter, and an access catheter hub configured to adjust an axial position and a rotational position of an access catheter, the access catheter further configured to laterally deflect a distal deflection zone of the access catheter.

Abstract: A method of performing a neurovascular procedure includes providing an assembly including a guidewire having a guidewire hub, an access catheter having an access catheter hub, and a guide catheter having a guide catheter hub. The method includes coupling the guidewire hub to a first hub adapter, coupling the access catheter hub to a second hub adapter, and coupling the guide catheter hub to a third hub adapter. Each of the first hub adapter, the second hub adapter and the third hub adapter is movably carried by a support table. The method includes driving the assembly in response to movement of each of the first hub adapter, the second hub adapter and the third hub adapter along the support table until the assembly is positioned to achieve supra-aortic vessel access.

Abstract: A method of performing a neurovascular procedure includes providing a multi-catheter assembly including an access catheter, a guide catheter, and a procedure catheter, coupling the assembly to a robotic drive system, driving the assembly to achieve supra-aortic access, and driving a subset of the assembly to a neurovascular site. The subset includes the guide catheter and the procedure catheter. The method further includes proximally removing the access catheter and performing a neurovascular procedure using the procedure catheter.