Abstract: A method of priming an interventional device assembly includes providing the interventional device assembly including a first interventional device coupled to a first hub and a second interventional device coupled to a second hub arranged in a concentric stack, the second interventional device being positioned within a lumen of the first interventional device. The method includes coupling the interventional device assembly to a drive system while arranged in the concentric stack, axially advancing the first interventional device and the first hub relative to the second hub to decrease a depth of insertion of the second interventional device within the lumen of the first interventional device while maintaining a distal end of the second interventional device within the lumen of the first interventional device, and flushing the first interventional device with fluid after decreasing the depth of insertion of the second interventional device within the lumen of the first interventional device.

Abstract: A method for driving an interventional device assembly along a drive table. The method includes axially advancing an extendable member from an end of a main body of a drive table and axially advancing a hub adapter from a first axial position within the main body to a second axial position within the extendable member beyond the end of the main body. The hub adapter is configured to couple to a corresponding hub so that axial movement of the hub adapter drives axial movement of the corresponding hub.

Abstract: A catheter system with integrated fluidics management includes a first elongate, flexible tubular body having a proximal end, a distal end and at least one lumen, a hub on the proximal end of the tubular body, a valve system in communication with the hub, and a first port, a second port, and a third port in communication with the valve system. The valve system is configured to selectively place any one of the first port, the second port and the third port into communication with the lumen while simultaneously blocking the other two ports from communicating with the lumen.

Abstract: An interventional device assembly includes a first hub positioned along a drive table, the first hub having a proximal end and a distal end, an interventional device coupled to the first hub and extending distally therefrom, and a telescoping tube having a proximal end and a distal end. The proximal end of the telescoping tube is secured within an interior of the first hub between the proximal end of the first hub and the distal end of the first hub. The distal end of the telescoping tube is configured to secure to a second hub positioned along the drive table or a distal attachment coupled to the drive table. At least a portion of the interventional device extends through the telescoping tube.

Abstract: The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

Abstract: A method of achieving supra aortic access includes the steps of providing an assembly including a guidewire, an access catheter and a guide catheter, coaxially moveably assembled into a single multi-catheter assembly, coupling the assembly to a drive system, driving the assembly to an aortic arch, and advancing the access catheter to achieve supra-aortic access to a branch vessel off of the aortic arch.

Abstract: A method of performing a neurovascular procedure includes providing a multi-catheter assembly including an access catheter, a guide catheter, and a procedure catheter, coupling the assembly to a robotic drive system, driving the assembly to achieve supra-aortic access, and driving a subset of the assembly to a neurovascular site. The subset includes the guide catheter and the procedure catheter. The method further includes proximally removing the access catheter and performing a neurovascular procedure using the procedure catheter.

Abstract: An insert catheter having an elongate flexible body. The elongate flexible body has a proximal end, a distal end, a length of at least about 160 cm, a lumen extending from the proximal end to the distal end, and a side port in fluid communication with the lumen. The side port is positioned between about 30 cm to about 105 cm from the distal end of the elongate flexible body. A guidewire can extend through the lumen and the side port. The side port is configured to be positioned within a second interventional device during a neurovascular procedure. The insert catheter can have a pre-shaped tip on a distal portion of the elongate flexible body. The insert catheter can have a rail extending from the side port to the proximal end of the elongate flexible body. The rial can be configured to receive the guidewire.

Abstract: A neurovascular catheter for delivery through an aorta and into an ostium can include a tubular body between a proximal end to a distal end. The tubular body can have a length of 140 cm to 180 cm, a 5 Fr size, and an internal diameter of about 0.065? to about 0.067?. The tubular body can include a proximal portion and a distal portion. The distal portion can include a polymer layer and a layer of braids. The proximal portion can include a hypotube and the layer of braids.

Abstract: The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

Abstract: A method of priming an interventional device assembly includes providing the interventional device assembly including a first interventional device coupled to a first hub and a second interventional device coupled to a second hub arranged in a concentric stack, the second interventional device being positioned within a lumen of the first interventional device. The method includes coupling the interventional device assembly to a drive system while arranged in the concentric stack, axially advancing the first interventional device and the first hub relative to the second hub to decrease a depth of insertion of the second interventional device within the lumen of the first interventional device while maintaining a distal end of the second interventional device within the lumen of the first interventional device, and flushing the first interventional device with fluid after decreasing the depth of insertion of the second interventional device within the lumen of the first interventional device.

Abstract: A method of performing a neurovascular procedure includes providing an assembly including a guidewire having a guidewire hub, an access catheter having an access catheter hub, and a guide catheter having a guide catheter hub. The method includes coupling the guidewire hub to a first hub adapter, coupling the access catheter hub to a second hub adapter, and coupling the guide catheter hub to a third hub adapter. Each of the first hub adapter, the second hub adapter and the third hub adapter is movably carried by a support table. The method includes driving the assembly in response to movement of each of the first hub adapter, the second hub adapter and the third hub adapter along the support table until the assembly is positioned to achieve supra-aortic vessel access.

Abstract: A system for delivering a fluid to a target site of a patient's vasculature having a catheter having a proximal end, a distal end, and a lumen defined by an interior surface of the catheter extending longitudinally through the catheter between the proximal end and the distal end, a guiding element having a distal end, a proximal end, and an exterior surface, the guiding element positioned in the lumen creating an area, between the exterior surface of the guiding element and the interior surface of the catheter, having an effective cross-sectional area sized fluid communication while the guiding element is in the lumen. Also, a method of performing a neurovascular procedure includes providing a multi-catheter assembly including an access catheter, a guide catheter, and a procedure catheter, coupling the assembly to a robotic drive system, and injecting contrast media into the assembly without removing a guiding element.

Abstract: A method of priming an interventional device assembly includes providing the interventional device assembly, the interventional device assembly including a first interventional device and a second interventional device, the second interventional device being positioned within the first interventional device. The method further includes reciprocally moving at least one of the first interventional device and the second interventional device relative to the other of the first interventional device and the second interventional device while flushing a lumen between the first interventional device and the second interventional device with fluid to remove microbubbles from the lumen.

Abstract: A robotic drive system includes a drive table having a main body and an extendable member configured to be at least partially received within the main body and being extendable from an end of the main body. One or more hub adapters are coupled with the drive table and are configured to couple to a corresponding hub so that axial movement of the one or more hub adapters drives the corresponding hub.

Abstract: A drive system for achieving supra-aortic access and neurovascular treatment site access includes a guidewire hub configured to adjust an axial position and a rotational position of a guidewire, a procedure catheter hub configured to adjust an axial position and a rotational position of a procedure catheter, a guide catheter hub configured to adjust an axial position of a guide catheter, and an access catheter hub configured to adjust an axial position and a rotational position of an access catheter, the access catheter further configured to laterally deflect a distal deflection zone of the access catheter.

Abstract: A hub assembly includes a mount being axially movable along a drive surface, a catheter hub having a catheter, the catheter hub removably couplable with the mount, and a fluidics connector in fluid communication with the mount and the catheter hub to provide fluid and vacuum through the connector to the catheter hub.

Abstract: A fluidics management system includes a cassette configured to receive saline from a saline source, receive contrast from a contrast source, and receive vacuum from a vacuum source. The cassette includes a plurality of saline connectors, each of the plurality of saline connectors configured to couple to one of a plurality of catheters to provide saline thereto, a plurality of contrast connectors, each of the plurality of contrast connectors configured to couple to one of the plurality of catheters to provide contrast thereto, and a plurality of vacuum connectors, each of the plurality of vacuum connectors configured to couple to one of the plurality of catheters to provide vacuum thereto.

Abstract: A system for delivering a fluid to a target site of a patient's vasculature having a catheter having a proximal end, a distal end, and a lumen defined by an interior surface of the catheter extending longitudinally through the catheter between the proximal end and the distal end, a guiding element having a distal end, a proximal end, and an exterior surface, the guiding element positioned in the lumen creating an area, between the exterior surface of the guiding element and the interior surface of the catheter, having an effective cross-sectional area sized fluid communication while the guiding element is in the lumen. Also, a method of performing a neurovascular procedure includes providing a multi-catheter assembly including an access catheter, a guide catheter, and a procedure catheter, coupling the assembly to a robotic drive system, and injecting contrast media into the assembly without removing a guiding element.

Abstract: A system for performing a vascular procedure includes a robotic drive system and one or more hub assemblies operatively coupled to the robotic drive system, each of the one or more hub assemblies including a mount, a hub removably coupled to the mount, and an interventional device coupled to the hub. For each of the one or more hub assemblies, the mount is configured to be driven by the robotic drive system to drive the interventional device within a vasculature of a patient, the hub is configured to be uncoupled from the mount while the interventional device is positioned within the vasculature of the patient, and the hub is configured to be manually manipulated to navigate the interventional device to a vascular site while the hub is uncoupled from the mount.