Patents by Inventor Craig McClain

Craig McClain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENCAPSULATION OF PHOSPHODIESTERASE INHIBITORS TO TREAT ALCOHOLIC LIVER DISEASE
    Publication number: 20190275003
    Abstract: Provided herein are compositions for treating liver inflammation. The compositions include a biologically active phosphodiesterase 4 (PDE4) inhibitor and a liposome, the liposome encapsulating the PDE4 inhibitor. The liposome may be anionic and include both neutrally charged and negatively charged phospholipids. Encapsulation of the PDE4 inhibitor in the liposome facilitates targeted delivery to the liver while limiting access to the central nervous system.
    Type: Application
    Filed: November 8, 2017
    Publication date: September 12, 2019
    Inventors: Claudio Maldonado, Craig McClain, Shirish S. Barve, Leila Gobejishvili, Philip Bauer
  • Method for treating cytokine mediated hepatic injury
    Publication number: 20050164942
    Abstract: A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
    Type: Application
    Filed: March 22, 2005
    Publication date: July 28, 2005
    Applicants: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, ZymoGenetics
    Inventors: Peter Oeltgen, Paul Bishop, Craig McClain, Shirish Barve