Abstract: Provided herein are compositions for treating liver inflammation. The compositions include a biologically active phosphodiesterase 4 (PDE4) inhibitor and a liposome, the liposome encapsulating the PDE4 inhibitor. The liposome may be anionic and include both neutrally charged and negatively charged phospholipids. Encapsulation of the PDE4 inhibitor in the liposome facilitates targeted delivery to the liver while limiting access to the central nervous system.

Abstract: A wheel lug ring is provided having an annular body with a cavity formed on one side having a plurality of lug wells in a registered positioning to engage around a plurality of lug nuts holding a wheel to an axle. So positioned, the device forms a protective cavity for the lug nuts and lugs from moisture, ice, mud, and other road hazards.

Abstract: A wheel lug ring is provided having an annular body with a cavity formed on one side having a plurality of lug wells in a registered positioning to engage around a plurality of lug nuts holding a wheel to an axle. So positioned, the device forms a protective cavity for the lug nuts and lugs from moisture, ice, mud, and other road hazards.

Abstract: A lug nut covering device, called a lug ring, for a wheel comprising a circular ring with a convex exterior side, a concave interior side, reinforcement webbing attached to an inner wall of the concave interior side, one or more lug wells strategically placed within the reinforcement webbing wherein the lug wells fit over and onto one or more lug nuts on a wheel. The lug ring is a device to cover the lug nuts and wheel studs for decorative and protective purposes. The convex exterior can be made from any hard material including, aluminum alloys depending on the look that is desired. In the preferred embodiment, the interior portion of the lug ring is made from a high impact plastic, like a polycarbonate (PC). When the lug ring is pressed onto the lug nut, the walls of the lug well compresses upon the hard metal of the lug nuts and firmly attaches the lug ring to the wheel.

Abstract: A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.