Abstract: There is provided a range of novel compounds. These novel compounds may demonstrate abroad spectrum antibacterial and antifungal activity. These compounds may be active against the emerging polymyxin resistant bacteria. These compounds may also be useful when used in conjunction with other pharmaceutically active agents.

Abstract: There is provided a range of novel compounds. These novel compounds may demonstrate abroad spectrum antibacterial and antifungal activity. These compounds may be active against the emerging polymyxin resistant bacteria. These compounds may also be useful when used in conjunction with other pharmaceutically active agents.

Abstract: The present subject matter overcomes the deficiencies in the prior art by introducing or generating charged particles in an air stream and manipulating the air stream with magnetic fields operating on the charged particles. Embodiments of the present subject mater compress the air stream by accelerating charged particles with a moving magnetic field, where the magnetic field has a velocity perpendicular to its flux lines. The increased velocity of the charged particles increases the statistical mean particle velocity and thereby increases the pressure in the air stream. The compressed air stream is then heated and expanded through a second magnetic field. The expansion of the air stream substantially increases the velocity of the air stream and the charged particles therein. The interaction of the high velocity charged particles and the magnetic field imparts a force perpendicular to the flux lines, this force powers the movement of the magnetic field.

Abstract: The present subject matter overcomes the deficiencies in the prior art by introducing or generating charged particles in an air stream and manipulating the air stream with magnetic fields operating on the charged particles. Embodiments of the present subject mater compress the air stream by accelerating charged particles with a moving magnetic field, where the magnetic field has a velocity perpendicular to its flux lines. The increased velocity of the charged particles increases the statistical mean particle velocity and thereby increases the pressure in the air stream. The compressed air stream is then heated and expanded through a second magnetic field. The expansion of the air stream substantially increases the velocity of the air stream and the charged particles therein. The interaction of the high velocity charged particles and the magnetic field imparts a force perpendicular to the flux lines, this force powers the movement of the magnetic field.

Abstract: The present subject matter overcomes the deficiencies in the prior art by introducing or generating charged particles in an air stream and manipulating the air stream with magnetic fields operating on the charged particles. Embodiments of the present subject matter compress the air stream by accelerating charged particles with a moving magnetic field, where the magnetic field has a velocity perpendicular to its flux lines. The increased velocity of the charged particles increases the statistical mean particle velocity and thereby increases the pressure in the air stream. The compressed air stream is then heated and expanded through a second magnetic field. The expansion of the air stream substantially increases the velocity of the air stream and the charged particles therein. The interaction of the high velocity charged particles and the magnetic field imparts a force perpendicular to the flux lines, this force powers the movement of the magnetic field and can also be extracted in the form of mechanical work.

Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.

Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:

Abstract: The present subject matter overcomes the deficiencies in the prior art by introducing or generating charged particles in an air stream and manipulating the air stream with magnetic fields operating on the charged particles. Embodiments of the present subject mater compress the air stream by accelerating charged particles with a moving magnetic field, where the magnetic field has a velocity perpendicular to its flux lines. The increased velocity of the charged particles increases the statistical mean particle velocity and thereby increases the pressure in the air stream. The compressed air stream is then heated and expanded through a second magnetic field. The expansion of the air stream substantially increases the velocity of the air stream and the charged particles therein. The interaction of the high velocity charged particles and the magnetic field imparts a force perpendicular to the flux lines, this force powers the movement of the magnetic field and can also be extracted in the form of mechanical work.

Abstract: The present subject matter overcomes the deficiencies in the prior art by introducing or generating charged particles in an air stream and manipulating the air stream with magnetic fields operating on the charged particles. Embodiments of the present subject matter compress the air stream by accelerating charged particles with a moving magnetic field, where the magnetic field has a velocity perpendicular to its flux lines. The increased velocity of the charged particles increases the statistical mean particle velocity and thereby increases the pressure in the air stream. The compressed air stream is then heated and expanded through a second magnetic field. The expansion of the air stream substantially increases the velocity of the air stream and the charged particles therein. The interaction of the high velocity charged particles and the magnetic field imparts a force perpendicular to the flux lines, this force powers the movement of the magnetic field and can also be extracted in the form of mechanical work.

Abstract: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:

Abstract: A method for inhibiting angiogenesis in a subject comprising administering to the subject at least one compound of General Formula (I), wherein the ring or any chiral center(s) may be of any configuration; Z is sulphur, oxygen, CH2, C(O), C(O)HN, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X and X? are independently oxygen or nitrogen providing that at least one X of General Formula (I) is nitrogen, X or X? may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the following definition which includes but is not limited to H or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear, and R6 and R7 are hydrogen, or may combine to form a carbonyl function.

Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.

Abstract: A method of identifying biologically active compounds with defined selectivity profile comprises: (c) designing a library of compounds of formula (1) to scan molecular diversity; and (d) assaying the library of compounds in at least two different biological assays.

Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.

Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.

Abstract: A shaped hull with a fixed angle keel with respect to the hull that when heeled, orients the keel to an angle of attack substantially related to the heel angle. The angle of attack being sufficient to create on the keel a lateral force substantially equal and opposite to the lateral force derived from the wind. The submerged portion of the hull, however, remains symmetrical and oriented parallel to the course sail as is its associated drag contribution vector. Thereby reducing or substantially eliminating the lateral force generated by the hull and the associated drag contribution. The movement of the shaped hull induces a lateral force on the keel without generating a lateral force and its associated drag on the hull, thus providing a sailboat with reduced drag without resorting to the prior art methods and their associated disadvantages.