Abstract: A system and method for performing a research and analysis in the bioinformatics field which associates data from a variety of experimental platforms with preclinical and/or clinical samples and subjects. The system and method allows for the analysis of data stored therein received from a variety of experimental platforms, as well as association with preclinical and clinical sources. A fully integrated medical informatics/molecular bioinformatics database/analysis package is provided herein suitable for accelerated target discovery, diagnosis, and treatments for molecular-based diseases. An identified relationship is used with a computational distribution for scoring nodes in a network built from a set of experimentally-derived condition-specific genomic or proteomic profiles for the development of new treatments, diagnoses, biomarker identification, or target identification.

Abstract: A system and method for performing a research and analysis in the bioinformatics field which associates data from a variety of experimental platforms with preclinical and/or clinical samples and subjects. The system and method allows for the analysis of data stored therein received from a variety of experimental platforms, as well as association with preclinical and clinical sources. A fully integrated medical informatics/molecular bioinformatics database/analysis package is provided herein suitable for accelerated target discovery, diagnosis, and treatments for molecular-based diseases. An identified relationship is used with a computational distribution for scoring nodes in a network built from a set of experimentally-derived condition-specific genomic or proteomic profiles for the development of new treatments, diagnoses, biomarker identification, or target identification.

Abstract: A method for inhibiting cell angiogenesis comprises contacting cells associated with undesired angiogenesis with an effective amount of an inhibitor of MEK or of an enzyme that is a member of the MAPK family. MEK inhibitors include MEK-directed proteases such as Bacillus anthracis lethal factor or a functional derivative thereof. Organic small molecule inhibitors of MEK include PD98059, U0126 and PD184352. The above contacting may be performed in vivo, in a human or other mammalian subject. Also included is a method to treat a mammalian subject having a disease or condition associated with undesired angiogenesis or neovascularization, comprising administering to the subject an effective amount of a pharmaceutical composition that comprises an inhibitor of MEK or of an enzyme that is a member of the MAPK family, as noted above, and pharmaceutically acceptable carrier or excipient.