Patents by Inventor Craig Patrick Galligan
Craig Patrick Galligan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240090869Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.Type: ApplicationFiled: November 27, 2023Publication date: March 21, 2024Inventors: David Andrew Shoudy, Craig Patrick Galligan, Weston Blaine Griffin, Jeffrey Michael Ashe, Warren Lee, James Enrico Sabatini
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Patent number: 11826197Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.Type: GrantFiled: May 13, 2021Date of Patent: November 28, 2023Assignee: General Electric CompanyInventors: David Andrew Shoudy, Craig Patrick Galligan, Weston Blaine Griffin, Jeffrey Michael Ashe, Warren Lee, James Enrico Sabatini
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Publication number: 20220361844Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.Type: ApplicationFiled: May 13, 2021Publication date: November 17, 2022Inventors: David Andrew Shoudy, Craig Patrick Galligan, Weston Blaine Griffin, Jeffrey Michael Ashe, Warren Lee, James Enrico Sabatini
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Patent number: 11402349Abstract: The present disclosure relates to the manufacture and use of redox electrodes and their use in cell lysis. In certain embodiments, the redox electrodes are manufactured using a hybrid material approach, such as using a redox polymer in combination with a support substrate, such as cellulose fibers or paper. In certain implementations, the redox electrodes are suitable for use at voltages greater than 25 Volts.Type: GrantFiled: December 3, 2015Date of Patent: August 2, 2022Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Andrea Jeannine Peters, Thomas Elliot Stecher, Craig Patrick Galligan, Christopher Michael Puleo, Ralf Lenigk
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Publication number: 20220041976Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.Type: ApplicationFiled: August 30, 2019Publication date: February 10, 2022Inventors: Matthew Jeremiah Misner, Rachel Marie Gettings, Christine Angela Morton, Erik Leeming Kvam, Jason William CASTLE, Anindya Kanti De, Jared Timothy Hale, Craig Patrick Galligan, Vincent Francis Pizzi
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Patent number: 11033859Abstract: A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.Type: GrantFiled: June 19, 2018Date of Patent: June 15, 2021Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Christopher Michael Puleo, John Richard Nelson, Patrick McCoy Spooner, Ralf Lenigk, Nicole Lea Wood, Li Zhu, Craig Patrick Galligan
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Patent number: 11028359Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.Type: GrantFiled: September 11, 2018Date of Patent: June 8, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Matthew Jeremiah Misner, Rachel Marie Gettings, Christine Angela Morton, Erik Leeming Kvam, Jason William Castle, Anindya Kanti De, Jared Timothy Hale, Craig Patrick Galligan, Vincent Francis Pizzi
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Patent number: 10787695Abstract: A system includes a bacteria culture array that includes a plurality of chambers each configured to receive a portion of a sample that includes bacteria. Each individual chamber of the plurality of chambers includes a chamber opening configured to permit access of the portion of the sample to the individual chamber. The system also includes one or more sensors configured to collect data from the individual chamber. The sensors are configured to contact the sample. Additionally, the system includes a monitoring and analysis system that includes a processor configured to receive the data from the one or more sensors at a first time and a second time, compare the data received at the second time to the data received at the first time, and identify a portion of the plurality of chambers of the bacteria culture array based on the comparing.Type: GrantFiled: June 1, 2017Date of Patent: September 29, 2020Assignee: General Electric CompanyInventors: Christopher Michael Puleo, Christine Lynne Surrette, Erik Leeming Kvam, Steven Yuehin Go, Feng Chen, John Richard Nelson, Craig Patrick Galligan, Radislav Alexandrovich Potyrailo, Gregory Andrew Grossmann
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Patent number: 10602950Abstract: The present approach relates to the fabrication and use of a probe array having multiple individual probes. In one embodiment, the probes of the probe array may be functionalized such that certain of the probes are suitable for electrical sensing (e.g., recording) or stimulation, non-electrical sensing or stimulation (e.g., chemical sensing and/or release of biomolecules when activated), or a combination of electrical and non-electrical sensing or stimulation.Type: GrantFiled: December 13, 2016Date of Patent: March 31, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Jeffrey M. Ashe, Kaustubh Ravindra Nagarkar, Christopher Michael Puleo, Christopher Fred Keimel, Craig Patrick Galligan, Yizhen Lin, Nancy Cecelia Stoffel, Richard Vanfleet, Robert Davis, Guohai Chen
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Publication number: 20200080047Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.Type: ApplicationFiled: September 11, 2018Publication date: March 12, 2020Inventors: Matthew Jeremiah Misner, Rachel Marie Gettings, Christine Angela Morton, Erik Leeming Kvam, Jason William Castle, Anindya Kanti De, Jared Timothy Hale, Craig Patrick Galligan, Vincent Francis Pizzi
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Patent number: 10518196Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.Type: GrantFiled: July 13, 2016Date of Patent: December 31, 2019Assignee: General Electric CompanyInventors: Christopher Michael Puleo, Craig Patrick Galligan, Gregory Andrew Grossman, Erik Leeming Kvam, Robert Scott Duthie, Kenneth Wayne Rigby, Paul Michael Smigelski, Jr., Victoria Eugenia Cotero, Jason William Castle, John Donald Burczak, James Edward Rothman
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Publication number: 20190366079Abstract: The subject matter of the present disclosure generally relates to a method and system for providing a bi-directional neural interface having an electrode configured to be positioned on a nerve; a substrate holding the electrode; a biocompatible insulator configured to electrically isolate the electrode when the electrode is positioned on the nerve, wherein the biocompatible insulator is formed in place about the electrode; and a pulse generator configured to deliver energy pulses to the electrode.Type: ApplicationFiled: March 13, 2017Publication date: December 5, 2019Inventors: Jeffrey Michael Ashe, Craig Patrick Galligan, Christopher Michael Puleo, Tzu-Jen KAO
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Publication number: 20190254546Abstract: The present approach relates to the fabrication of probes of a probe array device using wire bonding techniques. In certain implementation, a wire bond apparatus bonds ones end of a wire to a region of a probe array substrate. The second end, however, is not bonded to the substrate and instead is either fabricated to be vertical with respect to the substrate or raised from a non-bonded site to be vertical. The process may be repeated to form multiple probes of the probe array.Type: ApplicationFiled: February 22, 2018Publication date: August 22, 2019Inventors: Craig Patrick Galligan, Nancy Cecelia Stoffel, Eric Patrick Davis, Kaustubh Ravindra Nagarkar
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Publication number: 20180361317Abstract: A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.Type: ApplicationFiled: June 19, 2018Publication date: December 20, 2018Inventors: Christopher Michael Puleo, John Richard Nelson, Patrick McCoy Spooner, Ralf Lenigk, Nicole Lea Wood, Li Zhu, Craig Patrick Galligan
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Publication number: 20180345278Abstract: A system includes a bacteria culture array that includes a plurality of chambers each configured to receive a portion of a sample that includes bacteria. Each individual chamber of the plurality of chambers includes a chamber opening configured to permit access of the portion of the sample to the individual chamber. The system also includes one or more sensors configured to collect data from the individual chamber. The sensors are configured to contact the sample. Additionally, the system includes a monitoring and analysis system that includes a processor configured to receive the data from the one or more sensors at a first time and a second time, compare the data received at the second time to the data received at the first time, and identify a portion of the plurality of chambers of the bacteria culture array based on the comparing.Type: ApplicationFiled: June 1, 2017Publication date: December 6, 2018Inventors: Christopher Michael Puleo, Christine Lynne Surrette, Erik Leeming Kvam, Steven Yuehin Go, Feng Chen, John Richard Nelson, Craig Patrick Galligan, Radislav Alexandrovich Potyrailo, Gregory Andrew Grossmann
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Patent number: 9999856Abstract: A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.Type: GrantFiled: July 26, 2013Date of Patent: June 19, 2018Assignee: General Electric CompanyInventors: Christopher Michael Puleo, John Richard Nelson, Patrick McCoy Spooner, Ralf Lenigk, Nichole Lea Wood, Li Zhu, Craig Patrick Galligan
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Publication number: 20180160929Abstract: The present approach relates to the fabrication and use of a probe array having multiple individual probes. In one embodiment, the probes of the probe array may be functionalized such that certain of the probes are suitable for electrical sensing (e.g., recording) or stimulation, non-electrical sensing or stimulation (e.g., chemical sensing and/or release of biomolecules when activated), or a combination of electrical and non-electrical sensing or stimulation.Type: ApplicationFiled: December 13, 2016Publication date: June 14, 2018Inventors: Jeffrey M. Ashe, Kaustubh Ravindra Nagarkar, Christopher Michael Puleo, Christopher Fred Keimel, Craig Patrick Galligan, Yizhen Lin, Nancy Cecelia Stoffel, Richard Vanfleet, Robert Davis, Guohai Chen
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Publication number: 20180001231Abstract: A separation device, system and associated method are provided herein for separation of particulates form a base fluid. The separation device comprises a first microchannel comprising a fluid inlet and a mesofluidic collection chamber. The mesofluidic collection chamber has a first side and a second side, wherein the mesofluidic collection chamber is operatively coupled to the first microchannel on the first side, and wherein the mesofluidic collection chamber comprises a first fluid outlet at the second side, such that the fluid inlet, first microchannel, and first fluid outlet are in fluidic communication via the mesofluidic collection chamber.Type: ApplicationFiled: July 13, 2016Publication date: January 4, 2018Inventors: Christopher Michael Puleo, Craig Patrick Galligan, Gregory Andrew Grossmann, Erik Leeming Kvam, Robert Scott Duthie, Kenneth Wayne Rigby, Paul Michael Smigelski, JR., Victoria Eugenia Cotero, Jason William Castle, John Donald Burczak, James Edward Rothman
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Publication number: 20170363561Abstract: The present disclosure relates to the manufacture and use of redox electrodes and their use in cell lysis. In certain embodiments, the redox electrodes are manufactured using a hybrid material approach, such as using a redox polymer in combination with a support substrate, such as cellulose fibers or paper. In certain implementations, the redox electrodes are suitable for use at voltages greater than 25 Volts.Type: ApplicationFiled: December 3, 2015Publication date: December 21, 2017Inventors: Andrea Jeannine Peters, Thomas Elliot Stecher, Craig Patrick Galligan, Christopher Michael Puleo, Ralf Lenigk
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Publication number: 20160161437Abstract: The present disclosure relates to the manufacture and use of redox electrodes. In certain embodiments, the redox electrodes are manufactured using a hybrid material approach, such as using a redox polymer in combination with a support substrate, such as cellulose fibers or paper. In certain implementations, the redox electrodes are suitable for use at voltages greater than 25 V.Type: ApplicationFiled: December 3, 2014Publication date: June 9, 2016Inventors: Andrea Jeannine Peters, Thomas Elliot Stecher, Craig Patrick Galligan, Christopher Michael Puleo, Ralf Lenigk