Patents by Inventor Craig R. Halberstadt
Craig R. Halberstadt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240082311Abstract: Provided herein are methods, compositions of matter, and devices for treating neurological diseases and illnesses, including spinal cord injury.Type: ApplicationFiled: January 28, 2022Publication date: March 14, 2024Inventors: Francois BINETTE, Jennifer BAHR-DAVIDSON, Rami SKALITER, Kento ONISHI, Nathan C. MANLEY, Craig R. HALBERSTADT, Erik M. WHITELEY
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Publication number: 20230139899Abstract: Methods for differentiating human pluripotent stem cells to dorsal neuroectoderm progenitors and further to glial progenitor cells and oligodendrocyte progenitor cells (OPCs) using inhibitors of BMP signaling and MAPK/ERK signaling are provided. Also provided are cells and cellular compositions obtained by such methods, and uses of such cells. Further provided are methods and protocols for efficiently differentiating human pluripotent stem cells to OPCs in the absence of the ventralizing morphogen SHH or a SHH signaling activator. The methods of the present disclosure reproducibly produce dorsal neuroectoderm progenitor cells by day 7 of the differentiation process, glial progenitor cells by day 21 of the differentiation process and OPCs by day 42 of the differentiation process.Type: ApplicationFiled: December 2, 2022Publication date: May 4, 2023Inventors: Kento ONISHI, Nathan C. MANLEY, Craig R. HALBERSTADT, Erik M. WHITELEY
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Patent number: 11603518Abstract: Methods for differentiating human pluripotent stem cells to dorsal neuroectoderm progenitors and further to glial progenitor cells and oligodendrocyte progenitor cells (OPCs) using inhibitors of BMP signaling and MAPK/ERK signaling are provided. Also provided are cells and cellular compositions obtained by such methods, and uses of such cells. Further provided are methods and protocols for efficiently differentiating human pluripotent stem cells to OPCs in the absence of the ventralizing morphogen SHH or a SHH signaling activator. The methods of the present disclosure reproducibly produce dorsal neuroectoderm progenitor cells by day 7 of the differentiation process, glial progenitor cells by day 21 of the differentiation process and OPCs by day 42 of the differentiation process.Type: GrantFiled: January 23, 2020Date of Patent: March 14, 2023Assignee: ASTERIAS BIOTHERAPEUTICS, INC.Inventors: Kento Onishi, Nathan C. Manley, Craig R. Halberstadt, Erik M. Whiteley
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Publication number: 20220267723Abstract: Methods for differentiating pluripotent stem cells to neuroectoderm in dynamic suspension culture using small molecule or protein inhibitors of TGF?/Activin/Nodal signaling and BMP signaling are provided. Also provided are methot and protocols for differentiating pluripotent stem cells such as human embryonic stem cells first to neuroectoderm, then further to glial progenitor cells, and further to oligodendrocyte progenitor cells (OPCs), and compositions obtained thereby. The methods of the present disclosure reproducibly produce neuroectoderm progenitor cells by day 7 of the differentiation process, glial progenitor cells by day 21 of the differentiation process and OPCs by day 42 of the differentiation process.Type: ApplicationFiled: September 19, 2019Publication date: August 25, 2022Inventors: Rekha R. Nair, Stephanie Kayser, Abhirath S. PARIKH, Uzma Shoukat-Mumtaz, Erik Michael Whiteley, Nathan C. Manley, Craig R. Halberstadt
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Publication number: 20210238600Abstract: The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.Type: ApplicationFiled: February 9, 2021Publication date: August 5, 2021Inventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric S. Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Jr., Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Patent number: 11066666Abstract: The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.Type: GrantFiled: March 19, 2018Date of Patent: July 20, 2021Assignee: inRegenInventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Publication number: 20200231932Abstract: Methods for differentiating human pluripotent stem cells to dorsal neuroectoderm progenitors and further to glial progenitor cells and oligodendrocyte progenitor cells (OPCs) using inhibitors of BMP signaling and MAPK/ERK signaling are provided. Also provided are cells and cellular compositions obtained by such methods, and uses of such cells. Further provided are methods and protocols for efficiently differentiating human pluripotent stem cells to OPCs in the absence of the ventralizing morphogen SHH or a SHH signaling activator. The methods of the present disclosure reproducibly produce dorsal neuroectoderm progenitor cells by day 7 of the differentiation process, glial progenitor cells by day 21 of the differentiation process and OPCs by day 42 of the differentiation process.Type: ApplicationFiled: January 23, 2020Publication date: July 23, 2020Applicant: Asterias Biotherapeutics, Inc.Inventors: Kento Onishi, Nathan C. Manley, Craig R. Halberstadt, Erik M. Whiteley
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Publication number: 20200087622Abstract: Methods for differentiating pluripotent stem cells to neuroectoderm in dynamic suspension culture using small molecule or protein inhibitors of TGF?/Activin/Nodal signaling and BMP signaling are provided. Also provided are methods and protocols for differentiating pluripotent stem cells such as human embryonic stem cells first to neuroectoderm, then further to glial progenitor cells, and further to oligodendrocyte progenitor cells (OPCs), and compositions obtained thereby. The methods of the present disclosure reproducibly produce neuroectoderm progenitor cells by day 7 of the differentiation process, glial progenitor cells by day 21 of the differentiation process and OPCs by day 42 of the differentiation process.Type: ApplicationFiled: September 19, 2019Publication date: March 19, 2020Applicant: Lineage Cell Therapeutics, Inc.Inventors: Rekha R. Nair, Stephanie Kayser, Abhirath S. Parikh, Uzma Shoukat-Mumtaz, Erik Michael Whiteley, Nathan C. Manley, Craig R. Halberstadt
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Publication number: 20180282726Abstract: The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.Type: ApplicationFiled: March 19, 2018Publication date: October 4, 2018Inventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darrell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Patent number: 10077442Abstract: The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.Type: GrantFiled: May 12, 2011Date of Patent: September 18, 2018Assignee: inRegenInventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Patent number: 10030242Abstract: The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.Type: GrantFiled: May 12, 2011Date of Patent: July 24, 2018Assignee: InRegenInventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Publication number: 20170368102Abstract: The present invention concerns therapeutic formulations containing active agents, such bioactive cell populations, and methods of making and using the same.Type: ApplicationFiled: July 6, 2017Publication date: December 28, 2017Inventors: Joydeep Basu, Richard Payne, Neil F. Robbins, Oluwatoyin A. Knight, Deepak Jain, Craig R. Halberstadt, Monica A. Serban
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Patent number: 9724367Abstract: The present invention concerns phase changing injectable formulations for organ augmentation containing active agents, such as bioactive cell populations, and methods of making and using the same.Type: GrantFiled: November 10, 2011Date of Patent: August 8, 2017Assignee: RegenMed (Cayman) LTD.Inventors: Joydeep Basu, Richard Payne, Neil F. Robbins, Oluwatoyin A. Knight, Deepak Jain, Craig R. Halberstadt, Monica A. Serban
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Publication number: 20150030657Abstract: The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.Type: ApplicationFiled: May 3, 2011Publication date: January 29, 2015Applicant: TENGION, INC.Inventors: John W. Ludlow, Manuel J. Jayo, Joydeep Basu, Timothy A. Bertram, Christopher W. Genheimer, Kelly I. Guthrie, Roger M. Ilagan, Deepak Jain, Oluwatoyin A. Knight, Richard Payne, Sarah F. Quinlan, H. Scott Rapoport, Namrata D. Sangha, Jacob E. Shokes, Teresa B. Burnette, Sarah A. Boyd, Craig R. Halberstadt, Dominic M. Justewicz, Elias A. Rivera, Wendy Sharp, Neil F. Robbins
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Publication number: 20130330364Abstract: The present invention concerns therapeutic formulations containing active agents, such bioactive cell populations, and methods of making and using the same.Type: ApplicationFiled: November 10, 2011Publication date: December 12, 2013Applicant: TENGION, INC.Inventors: Joydeep Basu, Richard Payne, Neil F. Robbins, Oluwatoyin A. Knight, Deepak Jain, Craig R. Halberstadt, Monica A. Serban
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Patent number: 6218182Abstract: A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media; allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.Type: GrantFiled: December 21, 1999Date of Patent: April 17, 2001Assignee: Advanced Tissue SciencesInventors: Brian A. Naughton, Craig R. Halberstadt, Benson Sibanda
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Patent number: 6008049Abstract: A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.Type: GrantFiled: August 19, 1998Date of Patent: December 28, 1999Assignee: Advanced Tissue Sciences, Inc.Inventors: Brian A. Naughton, Craig R. Halberstadt, Benson Sibanda
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Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
Patent number: 5827729Abstract: A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.Type: GrantFiled: April 23, 1996Date of Patent: October 27, 1998Assignee: Advanced Tissue SciencesInventors: Brian A. Naughton, Craig R. Halberstadt, Benson Sibanda -
Patent number: 5081035Abstract: A system for continuous perfusion culturing of anchorage-dependent and anchorage-independent mammalian cell lines, inter alia, wherein in vivo capillary bed conditions are simulated by providing a bioreactor having a growth chamber wherein the cells are grown between a multitubular array comprising at least three functionally separate, inert non-degradable and structurally strong tubes or sets of tubes. A constant nutrient gradient is maintained along the entire length of the tubes by perfusing medium through the tubes at a flow rate which is sufficient to expose all areas of the chamber to fresh medium by convective forces rather than diffusion. Oxygen transfer and removal of toxic wastes is improved by the invention herein. In a preferred embodiment, porous inert expanded Teflon tubes are employed having an inner diameter of approximately between 1 and 2 millimeters.Type: GrantFiled: February 11, 1991Date of Patent: January 14, 1992Assignee: The University of MichiganInventors: Craig R. Halberstadt, A. Rees Midgley