Abstract: The present invention provides a compound of Formula I: wherein R1 is: or a pharmaceutically acceptable salt thereof, useful for treating pain, including chronic pain, chronic lower back pain, diabetic peripheral neuropathic pain, and osteoarthritis pain.

Abstract: Systems, computer-implemented methods and apparatus, including computer program apparatus, implementing techniques for rendering an image. A target area is identified in the image and a set of pixels to sample is selected from the target area to sample. An attribute value is identified for each of a plurality of the pixels in the selected set, and an attribute value is predicted for the target area based on the identified attribute value. At least a portion of the foreground area can be rendered based on the predicted attribute value. A statistical sampling analysis can be used to predict a background color when rendering a foreground area of an image.