Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention concerns methods for treating progressive multiple sclerosis (MS) in a patient, and an article of manufacture with instructions for such use.

Abstract: A method is provided that can include activating at least two wireless communication channels in parallel, between a first wireless transceiver and a second wireless transceiver. Each of the at least two wireless communication channels can operate at a different radio carrier frequency, and the first wireless transceiver may be part of a first vehicle. The method can also include transmitting, by the first wireless transceiver, common information in parallel on the at least two wireless communication channels to the second wireless transceiver and deactivating the at least two wireless communication channels.

Abstract: In one embodiment a landing platform system using translating aircraft landing modules enables supported vehicles to reduce weight, costs, and complexity by use of simple undercarriage provisions other than landing gear. Additionally, such a system has the additional benefit of increasing operational efficiency by enabling inter-flight tasks to be undertaken before and after the aircraft is at the gate position—enabling a dramatic decrease in turnaround time.

Abstract: A chase for connecting a first table to a second table and for supporting a workspace accessory. The chase includes an upper portion configured to be coupled to a first tabletop and to a second tabletop. The upper portion defines a first hole. The chase further includes a lower portion removably coupled to the upper portion. The lower portion defines a second hole and at least partially defines a channel configured to receive one or more cables. Moreover, the chase includes a fastener received within the first hole of the upper portion and the second hole of the lower portion, and a connection member having a first end portion and a second end portion opposite the first end portion. The first end portion is coupled to the fastener. The second end portion is configured to be connected to the workspace accessory to support the workspace accessory.

Abstract: A storage container securing system, in one embodiment, may include a base for receiving at least a portion of a storage container, such as a cooler, and a shelf adjustably positioned within the base to adjust the location of the storage container. In another embodiment, a storage container securing system is described having slidable inserts configured to matingly engage a slot in a storage container. In another embodiment, a storage container securing system is described having a receiving slot configured to receive a protrusion of a storage container.

Abstract: A chase for connecting a first table to a second table and for supporting a workspace accessory. The chase includes an upper portion configured to be coupled to a first tabletop and to a second tabletop. The upper portion defines a first hole. The chase further includes a lower portion removably coupled to the upper portion. The lower portion defines a second hole and at least partially defines a channel configured to receive one or more cables. Moreover, the chase includes a fastener received within the first hole of the upper portion and the second hole of the lower portion, and a connection member having a first end portion and a second end portion opposite the first end portion. The first end portion is coupled to the fastener. The second end portion is configured to be connected to the workspace accessory to support the workspace accessory.

Abstract: A power tool (130) may include an end effector (200) configured to engage an object to be worked by the tool, a power unit (230), a drive assembly (210) configured to drive the end effector responsive to application of input power thereto, and a motor (220) configured to supply the input power to the drive assembly selectively based on operation of a power control assembly (240) that controls coupling of the motor to the power unit. The power control assembly includes a trigger (300) having a full range of motion (310) between a rest position and an actuated position. The power control assembly further defines a transition point (316) between a first region (312) and a second region (314) of the full range of motion. The power control assembly includes a first biasing assembly (330) that opposes movement of the trigger in the first region, and a second biasing assembly (340) that opposes movement of the trigger at least at the transition point.

Abstract: The present invention concerns methods for treating progressive multiple sclerosis (MS) in a patient, and an article of manufacture with instructions for such use.

Abstract: A furniture system includes a first table having a first tabletop and one or more first legs supporting the first tabletop. The first tabletop includes a first upper surface and a first lower surface opposite the first upper surface. The furniture system also includes a second table having a second tabletop and one or more second legs supporting the second tabletop. The second tabletop includes a second upper surface and a second lower surface opposite the second upper surface. A chase is coupled to the first lower surface and the second lower surface to physically connect the first table to the second table. The chase includes a first channel extending therethrough. The first channel is configured to receive one or more cables.

Abstract: A computer implemented lending management system and method are disclosed. A first user interface receives inputs on parameters for a loan being sought, a funding page is generated on a web server and a link to the funding page is provided for distribution to acquaintances. Acquaintances supporting the loan via the link responsive and provide identification including their relationship. Upon achieving funding for the amount of the loan, a payment system external to the lending management system is caused to create an electronic wallet for receiving funding from the lenders for provision to the user.

Abstract: The present invention relates to spiral wind turbines and an energy-harnessing system. The system features a plurality of spiral wind turbines adapted to collect drag energy of moving vehicles and for converting the collected energy into electricity. The spiral wind turbines can also be installed for collecting air flow energy from heating vents on rooftops, smokestacks or similar structures. The system uses wind energy along with captured moving air or heated air energy for producing electric power using electric generators and storing same using storage batteries. The turbines are vertically rotating, and the method of attachment/installation will depend on the type of turbine and the location. The system allows federal, state, and local governments, as well as others, to generate electricity passively.

Abstract: A ball launcher and method for actuating wellsite equipment at a wellsite is disclosed. The wellsite has wellhead equipment positioned at an inlet of a wellbore. The ball launcher includes a housing, a ball release, and a housing extension. The housing has a passage for receiving balls. The ball is release positionable about the housing. The ball release includes a feeder to selectively and sequentially release the balls from the housing. The housing extension includes a hopper tube and a feed tube. The hopper tube has an inlet to receive the balls from the housing, the feed tube extending at an angle from the hopper tube. The feed tube has an exit a distance above the wellhead equipment to release the balls therethrough whereby the balls are dropped into and activates the wellsite equipment in the wellbore.

Abstract: The present invention concerns methods for treating multiple sclerosis (MS) in a patient, and an article of manufac-ture with instructions for such use.

Abstract: A furniture system includes a first table having a first tabletop and one or more first legs supporting the first tabletop. The first tabletop includes a first upper surface and a first lower surface opposite the first upper surface. The furniture system also includes a second table having a second tabletop and one or more second legs supporting the second tabletop. The second tabletop includes a second upper surface and a second lower surface opposite the second upper surface. A chase is coupled to the first lower surface and the second lower surface to physically connect the first table to the second table. The chase includes a first channel extending therethrough. The first channel is configured to receive one or more cables.

Abstract: The present invention concerns methods for treating progressive multiple sclerosis (MS) in a patient, and an article of manufacture with instructions for such use.

Abstract: A method may include, by a network resource optimization system, receiving from a network node a resource request, determining a plurality of network resources based on the resource request, and determining a subset of network resources from the plurality of network resources and a network resource from the subset based on a score of each network resource. The score of each network resource may be based on a rate of acceptance of communication requests received or a number of communication sessions established. The method may include, by the network resource optimization system, transmitting a communication request to the determined network resource and receiving an acceptance from the network resource. The method may include, by the network resource optimization system, causing a selection mechanism to be activated at the network node, receiving from the network node a selection, and initiating the communication session in response to the selection.

Abstract: A multi-function sensor system comprises a dual-axis electromagnetic speed sensor and a depth transducer to enable various underwater or marine measurements to be achieved in a single unit thus reducing the space required on a vessel and the cost of having such multiple functions.

Abstract: A system for producing American Petroleum Institute Standards Group III Base Stock from vacuum gas oil, by injecting hydrogen, heating, partially saturating the vacuum gas oil through a plurality of hydrogen reactors connected in series with a liquid hourly space velocity (LHSV)?1 of from 0.5 to 2.5, forming a saturated heated base oil, and coproduct. The system fractionates the saturated heated base oil to while simultaneously refluxing a cooled fuel oil fraction forming an American Petroleum Institute Standards Group III Base Stock with less than 0.03% sulfur, with greater than 90% saturates and a viscosity index greater than 120 as defined by ASTM D-2270, a viscosity from 2 to 10 centistokes as defined by ASTM D-445 a boiling range from 600 degrees F. to 1050 degrees F., and a cold crank viscosity (CCS) between 1200 and 5000 centipoise at ?25 degrees C. and as defined by ASTM D-5293.