Patents by Inventor Craig Stolen
Craig Stolen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11963756Abstract: Systems and methods to provide remote patient monitoring for viral-respiratory symptoms, including coronavirus or COVID-19 symptoms are disclosed, including a signal receiver circuit configured to receive first and second physiologic information of a patient, the first physiologic information comprising respiration rate information of a patient and the second physiologic information different than the first physiologic information, and an assessment circuit configured to determine an indication of patient viral-respiratory disease using the received first and second physiologic information.Type: GrantFiled: September 8, 2021Date of Patent: April 23, 2024Assignee: Cardiac Pacemakers, Inc.Inventors: Craig Stolen, Pramodsingh Hirasingh Thakur, Rezwan Ahmed, Viktoria A. Averina
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Publication number: 20230337988Abstract: Systems and methods for detecting a physiological event or estimating a physiological parameter using ambulatory electrograms of a subject are discussed. An exemplary system includes a computing device that can receive ambulatory electrograms collected by an ambulatory medical device (AMD) associated with a subject, and apply the ambulatory electrograms to a trained machine learning model to estimate a physiological parameter or to detect a physiological event in the subject. The same or a different machine learning model can be trained to detect an operating status of the AMD using the ambulatory electrograms. The system comprises an output device to output the estimated physiological parameter, the detected physiological event, or the detected device operating status a user or a process such as to initiate or titrate a therapy.Type: ApplicationFiled: April 18, 2023Publication date: October 26, 2023Inventors: Ramesh Wariar, Viktoria A. Averina, Deepa Mahajan, Keith R. Maile, Bin Mi, Craig Stolen, Scott R. Vanderlinde
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Publication number: 20220071507Abstract: Systems and methods to provide remote patient monitoring for viral-respiratory symptoms, including coronavirus or COVID-19 symptoms are disclosed, including a signal receiver circuit configured to receive first and second physiologic information of a patient, the first physiologic information comprising respiration rate information of a patient and the second physiologic information different than the first physiologic information, and an assessment circuit configured to determine an indication of patient viral-respiratory disease using the received first and second physiologic information.Type: ApplicationFiled: September 8, 2021Publication date: March 10, 2022Inventors: Craig Stolen, Pramodsingh Hirasingh Thakur, Rezwan Ahmed, Viktoria A. Averina
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Patent number: 11207520Abstract: An example of a system includes a blood pressure modulation device and a controller. The blood pressure modulation device may be configured to deliver a therapy to chronically maintain blood pressure within a prescribed range. The blood pressure modulation device may include a neuromodulator configured to deliver neuromodulation energy to neural tissue in a spinal cord or near the spinal cord using a first parameter set. The controller may include analyzer circuitry configured to determine an actual or anticipated blood pressure demand event indicated for a blood pressure change, and therapy parameter adjuster circuitry configured to respond to the actual or anticipated blood pressure demand event by delivering neuromodulation energy using a second parameter set to change the blood pressure.Type: GrantFiled: May 17, 2019Date of Patent: December 28, 2021Assignees: Regents of the University of Minnesota, Boston Scientific Scimed, Inc.Inventors: Craig Stolen, Bryan Allen Clark, Manda L. Keller-Ross, Ninitha Margret Julfiya Asirvatham-Jeyaraj, Daniel P. Chantigian
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Publication number: 20210370057Abstract: A method for producing cardiomyocyte cells including implanting a substrate within a heart such that a first portion of the substrate is in physical contact with an endocardium and a second portion of the substrate is not in contact with the endocardium, maintaining the first portion of the substrate in contact with the endocardium for a time at least sufficient to form trabecular fibers extending between the endocardium and the second portion of the substrate, cutting away the trabecular fibers from the endocardium, cutting away the trabecular fibers from the substrate, and removing the trabecular fibers from the heart, wherein the trabecular fibers include cardiomyocyte cells.Type: ApplicationFiled: August 17, 2021Publication date: December 2, 2021Inventors: Thomas J. Herbst, Craig Stolen
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Patent number: 11116969Abstract: A method for producing cardiomyocyte cells including implanting a substrate within a heart such that a first portion of the substrate is in physical contact with an endocardium and a second portion of the substrate is not in contact with the endocardium, maintaining the first portion of the substrate in contact with the endocardium for a time at least sufficient to form trabecular fibers extending between the endocardium and the second portion of the substrate, cutting away the trabecular fibers from the endocardium, cutting away the trabecular fibers from the substrate, and removing the trabecular fibers from the heart, wherein the trabecular fibers include cardiomyocyte cells.Type: GrantFiled: October 1, 2018Date of Patent: September 14, 2021Assignee: Boston Scientific Scimed IncInventors: Thomas J. Herbst, Craig Stolen
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Patent number: 10758655Abstract: This document discusses, among other things, systems and methods to reduce ischemic or metabolic injury to a patient's heart. A system to reduce ischemic or metabolic injury to a patient's heart may include a pulse generator for generating electrical pulses or shock, a pacing lead with at least one pacing electrode configured to deliver electrical pulses received from the pulse generator to the patient's heart, a controller configured to control timing of electrical pulses to reduce wall stress of the heart, and a reservoir, fluidically coupled to a lumen and a pump, wherein the pump is configured, under control of the controller, to move contents from the reservoir through the lumen to an area of the heart with the reduced wall stress, wherein the contents include autologous respiration-competent mitochondria or other respiratory-promoting agents.Type: GrantFiled: August 11, 2017Date of Patent: September 1, 2020Assignee: Cardiac Pacemakers, Inc.Inventors: Barbara Ann Huibregtse, Thomas John Herbst, Craig Stolen, Eric M. Schneider, Lynne E. Swanson, Lili Liu
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Patent number: 10576285Abstract: An example of a system for modulating blood pressure may include a blood pressure monitoring circuit, a blood pressure modulation device, and a control circuit. The blood pressure monitoring circuit may be configured to sense signals and generate one or more blood pressure parameters indicative of the blood pressure and/or a vascular resistance and one or more activity parameters indicative of an activity level and/or a postural change using the sensed signals. The blood pressure modulation device may be configured to deliver a therapy modulating the blood pressure. The control circuit may be configured to control the therapy using therapy parameters, receive the one or more blood pressure parameters and the one or more activity parameters, analyze changes in the one or more blood pressure parameters that are correlated to changes in the one or more activity parameters, and adjust the therapy parameters using an outcome of the analysis.Type: GrantFiled: November 14, 2017Date of Patent: March 3, 2020Assignee: Boston Scientific Neuromodulation CorporationInventors: Elizabeth Mary Annoni, Kyle Harish Srivastava, Craig Stolen, Pramodsingh Hirasingh Thakur, Bradley Lawrence Hershey, Stephen B. Ruble, William Conrad Stoffregen, Bryan Allen Clark
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Publication number: 20190351234Abstract: An example of a system includes a blood pressure modulation device and a controller. The blood pressure modulation device may be configured to deliver a therapy to chronically maintain blood pressure within a prescribed range. The blood pressure modulation device may include a neuromodulator configured to deliver neuromodulation energy to neural tissue in a spinal cord or near the spinal cord using a first parameter set. The controller may include analyzer circuitry configured to determine an actual or anticipated blood pressure demand event indicated for a blood pressure change, and therapy parameter adjuster circuitry configured to respond to the actual or anticipated blood pressure demand event by delivering neuromodulation energy using a second parameter set to change the blood pressure.Type: ApplicationFiled: May 17, 2019Publication date: November 21, 2019Inventors: Craig Stolen, Bryan Allen Clark, Manda L. Keller-Ross, Ninitha Margret Julfiya Asirvatham-Jeyaraj, Daniel P. Chantigian
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Publication number: 20190030327Abstract: A method for producing cardiomyocyte cells including implanting a substrate within a heart such that a first portion of the substrate is in physical contact with an endocardium and a second portion of the substrate is not in contact with the endocardium, maintaining the first portion of the substrate in contact with the endocardium for a time at least sufficient to form trabecular fibers extending between the endocardium and the second portion of the substrate, cutting away the trabecular fibers from the endocardium, cutting away the trabecular fibers from the substrate, and removing the trabecular fibers from the heart, wherein the trabecular fibers include cardiomyocyte cells.Type: ApplicationFiled: October 1, 2018Publication date: January 31, 2019Inventors: Thomas J. Herbst, Craig Stolen
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Patent number: 10188353Abstract: A system for monitoring autonomic health may include an autonomic nerve stimulation (ANS) dose delivery system and a response extractor. The response extractor may be configured to record physiological parameter values including first population data that includes evoked response (ER) values corresponding to evoked physiological responses, and second population data that includes reference values that include no effect (NE) values corresponding to times without a physiological response. The response monitor may calculate evoked response metrics (ERMs) using the first and second population data where each of the ERMs may be dependent on background autonomic activity. The response extractor may analyze the ERMs to provide ERM analysis, and provide an indication of autonomic health using the ERM analysis.Type: GrantFiled: September 22, 2016Date of Patent: January 29, 2019Assignee: Cardiac Pacemakers, Inc.Inventors: Craig Stolen, Stephen B. Ruble, Rahul Agarwal, Nicholas Wold
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Patent number: 10130817Abstract: A method may include delivering autonomic neural stimulation (ANS) therapy, including delivering stimulation pulses to evoke physiological responses. The method may further include recording physiological parameter values, including recording first population data, the first population data including evoked response (ER) values corresponding to the evoked physiological responses, and recording second population data, the second population data including reference values that include no effect (NE) values corresponding to times without an evoked physiological response. The method may further include quantifying a relationship between the first population data and the second population data, and analyzing the quantified relationship for a signature to indicate if the stimulation pulses are evoking desired physiological responses.Type: GrantFiled: October 13, 2015Date of Patent: November 20, 2018Assignee: Cardiac Pacemakers, Inc.Inventors: Craig Stolen, Rahul Agarwal, Nicholas Wold, Stephen B. Ruble
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Patent number: 10118034Abstract: A method for producing cardiomyocyte cells including implanting a substrate within a heart such that a first portion of the substrate is in physical contact with an endocardium and a second portion of the substrate is not in contact with the endocardium, maintaining the first portion of the substrate in contact with the endocardium for a time at least sufficient to form trabecular fibers extending between the endocardium and the second portion of the substrate, cutting away the trabecular fibers from the endocardium, cutting away the trabecular fibers from the substrate, and removing the trabecular fibers from the heart, wherein the trabecular fibers include cardiomyocyte cells.Type: GrantFiled: August 17, 2016Date of Patent: November 6, 2018Assignee: Boston Scientific Scimed, Inc.Inventors: Thomas J. Herbst, Craig Stolen
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Publication number: 20180133480Abstract: An example of a system for modulating blood pressure may include a blood pressure monitoring circuit, a blood pressure modulation device, and a control circuit. The blood pressure monitoring circuit may be configured to sense signals and generate one or more blood pressure parameters indicative of the blood pressure and/or a vascular resistance and one or more activity parameters indicative of an activity level and/or a postural change using the sensed signals. The blood pressure modulation device may be configured to deliver a therapy modulating the blood pressure. The control circuit may be configured to control the therapy using therapy parameters, receive the one or more blood pressure parameters and the one or more activity parameters, analyze changes in the one or more blood pressure parameters that are correlated to changes in the one or more activity parameters, and adjust the therapy parameters using an outcome of the analysis.Type: ApplicationFiled: November 14, 2017Publication date: May 17, 2018Inventors: Elizabeth Mary Annoni, Kyle Harish Srivastava, Craig Stolen, Pramodsingh Hirasingh Thakur, Bradley Lawrence Hershey, Stephen B. Ruble, William Conrad Stoffregen, Bryan Allen Clark
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Publication number: 20180043071Abstract: This document discusses, among other things, systems and methods to reduce ischemic or metabolic injury to a patient's heart. A system to reduce ischemic or metabolic injury to a patient's heart may include a pulse generator for generating electrical pulses or shock, a pacing lead with at least one pacing electrode configured to deliver electrical pulses received from the pulse generator to the patient's heart, a controller configured to control timing of electrical pulses to reduce wall stress of the heart, and a reservoir, fluidically coupled to a lumen and a pump, wherein the pump is configured, under control of the controller, to move contents from the reservoir through the lumen to an area of the heart with the reduced wall stress, wherein the contents include autologous respiration-competent mitochondria or other respiratory-promoting agents.Type: ApplicationFiled: August 11, 2017Publication date: February 15, 2018Inventors: Barbara Ann Huibregtse, Thomas John Herbst, Craig Stolen, Eric M. Schneider, Lynne E. Swanson, Lili Liu
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Publication number: 20170079598Abstract: A system for monitoring autonomic health may include an autonomic nerve stimulation (ANS) dose delivery system and a response extractor. The response extractor may be configured to record physiological parameter values including first population data that includes evoked response (ER) values corresponding to evoked physiological responses, and second population data that includes reference values that include no effect (NE) values corresponding to times without a physiological response. The response monitor may calculate evoked response metrics (ERMs) using the first and second population data where each of the ERMs may be dependent on background autonomic activity. The response extractor may analyze the ERMs to provide ERM analysis, and provide an indication of autonomic health using the ERM analysis.Type: ApplicationFiled: September 22, 2016Publication date: March 23, 2017Inventors: Craig Stolen, Stephen B. Ruble, Rahul Agarwal, Nicholas Wold
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Publication number: 20170050018Abstract: A method for producing cardiomyocyte cells including implanting a substrate within a heart such that a first portion of the substrate is in physical contact with an endocardium and a second portion of the substrate is not in contact with the endocardium, maintaining the first portion of the substrate in contact with the endocardium for a time at least sufficient to form trabecular fibers extending between the endocardium and the second portion of the substrate, cutting away the trabecular fibers from the endocardium, cutting away the trabecular fibers from the substrate, and removing the trabecular fibers from the heart, wherein the trabecular fibers include cardiomyocyte cells.Type: ApplicationFiled: August 17, 2016Publication date: February 23, 2017Inventors: Thomas J. Herbst, Craig Stolen
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Publication number: 20160101289Abstract: A method may include delivering autonomic neural stimulation (ANS) therapy, including delivering stimulation pulses to evoke physiological responses. The method may further include recording physiological parameter values, including recording first population data, the first population data including evoked response (ER) values corresponding to the evoked physiological responses, and recording second population data, the second population data including reference values that include no effect (NE) values corresponding to times without an evoked physiological response. The method may further include quantifying a relationship between the first population data and the second population data, and analyzing the quantified relationship for a signature to indicate if the stimulation pulses are evoking desired physiological responses.Type: ApplicationFiled: October 13, 2015Publication date: April 14, 2016Inventors: Craig Stolen, Rahul Agarwal, Nicholas Wold, Stephen B. Ruble
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Patent number: 9265969Abstract: Methods for modulating nerve function are disclosed. An example method for modulating nerve function may include providing a transgene including a neuron-specific promoter and a gene encoding a light-sensitive protein, delivering the transgene to a body tissue including one or more target neurons, implanting a light source adjacent to the cell bodies of the one or more target neurons, and emitting light from the light source. Light may be exposed to the cell bodies of the one or more target neurons and may cause a conformational change in the light-sensitive protein.Type: GrantFiled: December 10, 2012Date of Patent: February 23, 2016Assignee: Cardiac Pacemakers, Inc.Inventors: Allan C. Shuros, Craig Stolen
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Patent number: 9232897Abstract: Devices and methods for improving the sensitivity and specificity of heart failure (HF) detection are described. The devices and methods can detect a HF status such as using physiological sensor data and external biomarker assays. An apparatus can comprise ambulatory physiological sensors that can provide a first HF status indicator and a second HF status indicator to a user. An external biomarker sensor can provide an amount of a biomarker present, such as an assay for B-type natriuretic peptide (BNP), which provides information about HF status. A processor circuit can switch from a first HF detection mode to a second detection mode such as in response to the information from the biomarker sensor. The first detection mode can detect HF status using the first HF status indicator, and the second detection mode can detect HF status using the second HF status indicator. The second detection mode can have a higher specificity than the first detection mode.Type: GrantFiled: September 30, 2013Date of Patent: January 12, 2016Assignee: Cardiac Pacemakers, Inc.Inventors: Pramodsingh Hirasingh Thakur, Abhilash Patangay, Craig Stolen, Timothy Meyer