Abstract: The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.

Abstract: A system writes input data to a storage device as machine-written polynucleotides; and reads machine written polynucleotides from the storage device as output data. The storage device includes a flow cell including a plurality of storage wells in which machine written polynucleotides may be stored. The storage device may include a set of electrodes corresponding to the storage wells that allow for selective interactions with wells across the surface of a flow cell. Operation of the storage device may include receiving a read request associated with a particular location in the storage device, creating a copy of a nucleotide sequence located at the particular location in the storage device, transferring the copy of the nucleotide sequence to a read location, and reading the copy of the nucleotide sequence at the read location.

Abstract: An optical scanning system includes one or more Micro-Electro-Mechanical System (MEMS) Micro-Mirror Arrays (MMAs) used to scan a field-of-view (FOV) over a field-of-regard (FOR). The MEMS MMA is configured such that optical radiation from each point in the FOV does not land on or originate from out-of-phase mirror segments and a diffraction limited resolution of the optical system is limited by the size of the entrance pupil and not by the size of individual mirrors.

Abstract: A power tool system includes a power tool having a tool housing and a load disposed in the tool housing. The tool housing includes a battery pack receptacle having a set of tool terminals. The power tool system includes a set of battery packs. Each battery pack includes a battery pack housing operably connectable to the battery pack receptacle through a battery pack interface disposed on the battery pack housing, a set of battery cells disposed in the battery pack housing, and a set of battery pack terminals electrically connectable to the set of tool terminals and electrically connected to the set of battery cells. Each battery pack in the set of battery packs has a same nominal voltage and defines a common interface and at least a portion of the set of battery packs defines a total volume in a range of approximately 150 cm3 to 1300 cm3.

Abstract: Wound dressings for use in cases of a patient suffering a penetrating chest trauma. The wound dressing includes a base layer having a lower surface facing the wound and an upper surface facing away from the wound, and an aperture therethrough for locating over the wound, and a top layer extending over the aperture and at least a part of the upper surface. The base layer is connected to the top layer such that the wound dressing can transition from an open configuration in which the aperture and an area external to the wound dressing are in fluid communication via at least one opening at a perimeter between the base layer and the top layer, to a closed configuration in which the top layer forms a seal over the aperture.

Abstract: A system includes a computing device a personal protective equipment (PPE) device. The PPE device is configured to be worn by a worker and includes and at least one physiological sensor configured to generate physiological data indicative of one or more physiological characteristics of a worker. The computing device is configured to determine a safety risk score for the worker based at least in part on the physiological data and a risk profile associated with the worker.

Abstract: The technical description relates to an expandable intervertebral spacer configured to engage an intervertebral disk. An example expandable intervertebral spacer includes a main body, a first endplate, a second endplate, a driving member, and an actuation member. The expandable intervertebral spacer is transitions from a first configuration to a second configuration by structural interfacing between steps defined on the first endplate, the second endplate, and the driving member. Steps include a surface that lies on a plane disposed at a non-parallel angle to the longitudinal axis of the intervertebral spacer.

Abstract: A method of operating a gas turbine engine including an engine core including a turbine, compressor, combustor to combust a fuel, and core shaft connecting the turbine and compressor; a fan upstream of the engine core; a fan shaft; a gearbox that receives an input from the core shaft and outputs drive to the fan via the fan shaft; a primary oil loop system to supply oil to the gearbox; and a heat exchange system. The method includes controlling the heat exchange system to adjust fuel viscosity to be lower than or equal to 0.58 mm2/s on entry to the combustor at cruise conditions.

Abstract: An ocular protection device and treatment methods are disclosed. The device has a corneal shield with an attached handle. The handle may be used to move the corneal shield to better protect the eye from various treatment modalities. The handle may also be used to place tension on the eyelid to counteract the forces imposed by a treatment handpiece. A procedure for treating the eye is disclosed where multiple passes with a treatment handpiece cause a gradual increase in the temperature of an eyelid up to a treatment temperature. Once the treatment temperature has been met, occlusions in the Meibomian glands of the eyelid may be expressed. The procedure may be repeated recursively until a desired level of expression has been achieved.

Abstract: Provided is a system and method for creating luggage manifests, the method including: a) identifying, by at least one of at least one processor, a baggage source message (BSM) associated with an arrival of a luggage item of a passenger, wherein the BSM comprises an airport code associated with an airport and travel data of a first mode of travel carrier of the luggage item; b) matching, by at least one of the at least one processor, a passenger name of the passenger in the BSM with a passenger name in a manifest for a second mode of travel different from the first mode of travel, wherein the second mode of travel is local to the airport code; c) extracting, by at least one of the at least one processor, an International Air Transport Association (IATA) license plate number from the BSM; and d) creating, by at least one of the at least one processor, a luggage item manifest record for the luggage item, wherein the luggage item manifest record comprises the IATA license plate number, and wherein the luggage ite

Abstract: Provided is a system and method for creating a luggage manifest using a terminating b-type message, the method including: a) identifying, by at least one of at least one processor, a terminating baggage source message (BSM) associated with an arrival of a luggage item of a passenger, wherein the terminating BSM comprises an airport code associated with an airport and travel data of a first mode of travel carrier of the luggage item, and wherein the travel data comprises at least one of flight information, airline information, a name of the passenger, a passenger name record (PNR) number, and an International Air Transport Association (IATA) license plate number; b) matching, by at least one of the at least one processor, any of the travel data in the terminating BSM with travel data in a manifest for a second mode of travel different from the first mode of travel, wherein the second mode of travel is local to the airport code; c) based on matching any of the travel data in the terminating BSM with the travel

Abstract: A building system includes: an exterior mount; a wall panel; and an exterior attachment. The wall panel includes: a left column element carrying vertical loads through a left side of the wall panel abutting a right column element of an adjacent wall panel; an exterior surface extending across the left column element and cooperating with a second exterior surface of the adjacent wall panel to form an exterior façade; and a left channel section coupled to the left column element, recessed behind the exterior surface, cooperating with a right channel section of the adjacent wall panel to define an exterior mounting receptacle, facing outwardly from the wall panel, extending vertically between the wall panel and the adjacent wall panel, recessed behind the exterior façade, and configured to transiently retain the exterior mount. The exterior attachment: transiently installs on the exterior mount; and extends from the exterior façade.

Abstract: A composite shaft or rod formed by filament winding. The composite shaft is a solid shaft and the filament winding does not involve a mandrel. A filament core can be suspended between rotatable spindles and the filament materials can be laid directly onto the filament spindle, without any mandrel. A plurality of payout eyes can be used to simultaneously lay filament materials onto the filament core. A bridge plug can be formed with the solid composite shaft located within the bridge plug shell of the bridge plug.

Abstract: An example welding power supply includes: a power input configured to receive alternating current (AC) input power, and power conversion circuitry configured to: convert a first portion of the input power to welding power; output the welding power to a weld circuit; convert a second portion of the input power to preheating power; and output the preheating power to a preheater.

Abstract: Systems, methods, and computer-readable media are described for compact radar systems. In some examples, a compact radar system can include a first set of transmit antennas, a second set of receive antennas, one or more processors, and at least one computer-readable storage medium storing computer-executable instructions which, when executed by the one or more processors, cause the radar system to coordinate digital beam steering of the first set of transmit antennas and the second set of receive antennas, and coordinate digital beam forming with one or more of the second set of receive antennas to detect one or more objects within a distance of the radar system.

Abstract: Various methods and systems for tracking a luggage item of a passenger are disclosed. They may include, tracking, by at least one processor, a tracking device associated with the luggage item; and loading security screening information into memory of the tracking device, after the luggage item is screened by a first baggage screening requirement to travel using a first mode of travel. The method and systems may include generating, by at least one of the at least one processor, a baggage information message that includes the security screening information to a network interface of a computing system to screen the luggage item for a security threat that is the same as or lower than a first baggage screening requirement. This may enable the bypass rescreening of the luggage item at the second baggage screening requirement to transfer travel from the first mode of travel to a second mode of travel.

Abstract: The present disclosure provides embodiments of a composition comprising post-consumer recycled resin comprising: at least 50 weight percent polyolefin, having an initial limonene level of at least 5 ppm; virgin ethylene-based polymer; and at least one odor-active zeolite, wherein the odor-active zeolite has an FAU crystal structure, an MFI crystal structure, and/or beta crystal structure and a Si/Al molar ratio from 1 to 1000, wherein the composition has a reduced limonene level of less than 3 ppm.

Abstract: The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.