Abstract: Machine-learning (ML) techniques and models are described for predicting the number and severity of network attacks within a specified timeframe, such as the next fifteen minutes. In some embodiments, the techniques including training a ML model based on features extracted from a training dataset and applying the trained ML model to estimate (a) the probability of an attack happening on an account within a specified timeframe; (b) how many attacks are predicted to occur in the specified timeframe (if any); and/or (c) the severity of the attacks predicted to occur. A system may deploy preventative measures based on the ML model output to counter or mitigate the effects of predicted and coordinated network attacks.

Abstract: Methods for differentiating pluripotent stem cells to neuroectoderm in dynamic suspension culture using small molecule or protein inhibitors of TGF?/Activin/Nodal signaling and BMP signaling are provided. Also provided are methot and protocols for differentiating pluripotent stem cells such as human embryonic stem cells first to neuroectoderm, then further to glial progenitor cells, and further to oligodendrocyte progenitor cells (OPCs), and compositions obtained thereby. The methods of the present disclosure reproducibly produce neuroectoderm progenitor cells by day 7 of the differentiation process, glial progenitor cells by day 21 of the differentiation process and OPCs by day 42 of the differentiation process.

Abstract: Some implementations include a modular gun system for use in a wellbore comprising one or more charge segments each including a first electrical conductor having a first set of integrated electrical contacts.

Abstract: A bike bag includes a first storage compartment including a first rigid outer surface, the first storage compartment configured to be selectively closable. The bike bag further includes a second storage compartment including a second rigid outer surface, the second storage compartment separated from the first storage compartment by a divider. The second storage compartment is also configured to be selectively closable independently of the first storage compartment. The bike bag further includes an attachment system. The attachment system includes a first attachment member disposed at a first side of the bike bag and a second attachment member disposed at a second side of the bike bag (adjacent to the first side of the bike bag). The bike bag is selectively couplable, using the first attachment member and the second attachment member, to at least a top tube or a saddle of a bike.

Abstract: A power tool includes a housing having a motor housing portion and a handle portion extending from the motor housing portion. The motor housing portion and the handle portion are defined by cooperating first and second clamshell halves coupled together along a parting plane. A motor is supported within the motor housing portion and includes an output shaft defining an axis. A gear assembly includes a ring gear directly supported by the first and second clamshell halves, a pinion gear coupled for co-rotation with the output shaft, and planet gears meshed with the pinion gear and the ring gear. The power tool has an overall length measured along the axis from a rear end of the housing to a front end of the anvil between 106 mm and 125 mm, and is capable of delivering at least 500 foot-pounds of fastening torque to a workpiece through the anvil.

Abstract: A computer-implemented method of representing a first set of data items, wherein the method is performed by a first tree generator and comprises: allocating the first set of data items into a plurality of respective subsets; for each respective subset of data items, generating a respective hash tree based on the respective subset of data items, wherein the respective hash tree comprises a respective root node; and generating a respective first hash set representing the first set of data items, wherein the first hash set comprises each of the respective root nodes.

Abstract: A rapid-entry shoe having a rotating rear portion configured to be rotated around an axis of rotation and deflected at a fulcrum to create a stress in the rotating rear portion when the shoe is in a collapsed configuration to bias the shoe toward an uncollapsed configuration.

Abstract: Aspects of the disclosure are directed to estimating a frequency histogram for users across multiple platforms while maintaining accuracy, security, privacy, and/or computational efficiency thresholds. The frequency histogram can be estimated unbiasedly with a configurable variance. The computations for generating the frequency histogram can be differentially private, satisfy provable security, and be efficient.

Abstract: Subword tokenization is provided. The method comprises receiving a text document comprising n bytes and specifying a maximum token width of L bytes. An initial vocabulary of tokens is defined, wherein the tokens comprise a number of different n-grams of L or less bytes. The document is tokenized with the fewest number of tokens from the vocabulary according to a minimum total weight through a directed acyclic graph comprising nodes that represent intervals between the bytes in the document and edges that represent potential tokens from the vocabulary appearing in text of the document. Natural language processing is then performed on the text document according to the tokenization.

Abstract: Provided herein are surveillance systems, platforms, and methods for autonomous monitoring of clinical studies that address these technical challenges and improve the credibility and validity of a clinical study by ensuring reliability of the data that is collected. In certain aspects, these systems, platforms, and methods assist in the communication between those responsible for analyzing the clinical study data (e.g., the data scientists, etc.) and those responsible for collecting the data (e.g., the physicians and clinical staff, etc.), allowing for proactive debugging of gaps in data coverage and data availability while there is still an opportunity to address the conditions of the clinical study leading to the missing data.

Abstract: The present invention relates to 7,8-dihydro-5H-1,6-naphthyridine derivatives of formula (I) The present compounds are positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4) for use in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. An exemplary compound is e.g. compound 1 Data on the activity of exemplary compounds in an mAChR M4 cell-based assay is provided. 1 5-methyl-6- (3-pyrrolidin- 1-1-7,8- dihydro-5H-1,6- naphtbyridin- 6-yl)pyridine- 3-carbonitrile 320.

Abstract: A self-centering rail includes a first side portion and a second side portion that is opposite the first side portion. The first side portion is configured to couple to a first solar module frame when a first flange of the first solar module frame is received at the first rail clamp and the second rail clamp and when a frame self-centering member of the first solar module frame is received at the first rail self-centering member. The second side portion is configured to couple to a second solar module frame when a second flange of the second solar module frame is received at the third rail clamp and the fourth rail clamp and when a frame self-centering member of the second solar module frame is received at the second rail self-centering member.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: A water heater appliance may include a housing, a tank, a refrigeration system, and a controller. The tank may be attached to the housing. The tank may define an interior volume. The refrigeration system may include a sealed refrigerant loop in thermal communication with the tank to heat the interior volume. The controller may be operably coupled to the refrigeration system. The controller may be configured to direct a heater operation. The heater operation may include determining a voltage input for the water heater appliance, selecting, based on the determined voltage input, an operational mode from a plurality of predetermined mode options that include a high-voltage mode and a low-voltage mode, and directing the refrigeration system according to the selected operational mode.

Abstract: The technology disclosed herein enables resiliency of routing between NFs when degraded 5G NF topology information is provided to an SCP by an NRF. In a particular example, a method includes transmitting requests for NRF status from a Service Communications Proxy (SCP) to NRFs in a 5G network. The NRFs exchange messages with each other to determine whether Network Function (NF) topology information is available from the NRFs. The method further includes receiving responses to the requests in the SCP. The responses indicate a number of the NRFs from which the NF topology information is available. The method also includes identifying one or more failed NRFs of the NRFs that are in a failed state based on the responses. The NF topology information is aggregated from operative NRFs should one or more of the NRFs still be operative.

Abstract: Systems and methods for estimating the junction temperature of a semiconductor power device or a power module are described. The power module may include one or more SiC metal oxide semiconductor field effect transistors and the temperature is a junction temperature of the one or more SiC metal oxide semiconductor field effect transistors. The temperature of the power module may be a basis for adjusting operation of a vehicle.

Abstract: Various well-perforating systems and methods are disclosed incorporating a self-shunting detonator. The detonator may include an electrically-conductive detonator body. A resistor initiator inside the detonator body includes first and second leads. A grounding element inside the detonator body couples the detonator body to the first lead. An electrically-conductive clip coupled to the second lead includes an arm biased to electrical contact with an external surface of the detonator body to shunt the detonator. The arm is moveable away from the detonator body to un-shunt the detonator, such as automatically in response to insertion into a detonator housing.

Abstract: A rapid system development platform may provide for the ability to rapidly develop a remotely controlled and/or autonomously operated system, such as an unmanned aerial vehicle (e.g., drone), mobile robot, stationary robot, or other system. The platform may support database(s) that provide for equipment, such as hardware electronic and electrical components, to be selectable for inclusion with the system. The electronic equipment, for example, may include an electronic control unit (ECU) that is preconfigured to be utilized on a common bus and communicate with other electronic components selectable to be included on the system. The platform may support preconfigured software and/or firmware for downloading to the electronics to be executed thereby. The platform may provide one or more application programming interfaces (APIs) for supporting the system along with dashboard(s) that are preconfigured based on the type of system and data being communicated by the system.

Abstract: A shoe upper having a plurality of arms that expand the shoe opening when the topline of the upper is compressed toward the sole portion of the shoe.

Abstract: The invention relates to a pharmaceutically acceptable acid addition salt of: (i) S-oxprenolol; and (ii) phosphoric acid. Medical uses of the salt and compositions comprising the salt are also described.