Patents by Inventor Cristhian J. Ildefonso
Cristhian J. Ildefonso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240101607Abstract: Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral vectors and medicaments containing them are disclosed, which are useful in the prophylaxis, therapy, or amelioration of symptoms of one or more inflammatory-mediated mammalian diseases, such as age-related macular degeneration (AMD), arthritis, Bechet's disease, Best macular dystrophy, corneal inflammation, diabetic retinopathy, drusen formation, dry AMD, dry eye, geographic atrophy, glaucomaocular neovascularization, Lupus erythematosus, macular degeneration, Mallatia Leventinese and Doyne honeycomb retinal dystrophy, nephritis, ocular hypertension, ocular inflammation, recurrent uveitis, Sorsby fundus dystrophy, vasculitis, vitreoretinopathy, wet AMD, or related disorders.Type: ApplicationFiled: May 9, 2023Publication date: March 28, 2024Applicant: University of Florida Research Foundation, IncorporatedInventors: Douglas Grant McFadden, Alfred S. Lewin, Alexandra Rose Lucas, Cristhian J. Ildefonso, Mohammed Masmudur Rahman
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Patent number: 11739130Abstract: The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization.Type: GrantFiled: March 17, 2021Date of Patent: August 29, 2023Assignee: University of Florida Research Foundation, IncorporatedInventors: Cristhian J. Ildefonso, Alfred S. Lewin, Qiuhong Li
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Patent number: 11685767Abstract: Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral vectors and medicaments containing them are disclosed, which are useful in the prophylaxis, therapy, or amelioration of symptoms of one or more inflammatory-mediated mammalian diseases, such as age-related macular degeneration (AMD), arthritis, Bechet's disease, Best macular dystrophy, corneal inflammation, diabetic retinopathy, drusen formation, dry AMD, dry eye, geographic atrophy, glaucomaocular neovascularization, Lupus erythematosus, macular degeneration, Mallatia Leventinese and Doyne honeycomb retinal dystrophy, nephritis, ocular hypertension, ocular inflammation, recurrent uveitis, Sorsby fundus dystrophy, vasculitis, vitreoretinopathy, wet AMD, or related disorders.Type: GrantFiled: September 9, 2016Date of Patent: June 27, 2023Assignee: University of Florida Research Foundation, IncorporatedInventors: Douglas Grant McFadden, Alfred S. Lewin, Alexandra Rose Lucas, Cristhian J. Ildefonso, Mohammed Masmudur Rahman
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Publication number: 20230132355Abstract: The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization.Type: ApplicationFiled: March 17, 2021Publication date: April 27, 2023Applicant: University of Florida Research Foundation, IncorporatedInventors: Cristhian J. Ildefonso, Alfred S. Lewin, Qiuhong Li
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Publication number: 20220033826Abstract: Aspects of the disclosure relate to methods and compositions useful for treating bestrophinopathies, such as Best Disease.Type: ApplicationFiled: August 30, 2019Publication date: February 3, 2022Applicant: University of Florida Research Foundation, IncorporatedInventors: William W. Hauswirth, Alfred S. Lewin, Cristhian J. Ildefonso, Brianna M. Young
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Publication number: 20210371481Abstract: The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization.Type: ApplicationFiled: March 17, 2021Publication date: December 2, 2021Applicant: University of Florida Research Foundation, IncorporatedInventors: Cristhian J. Ildefonso, Alfred S. Lewin, Qiuhong Li
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Publication number: 20210300978Abstract: The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or inflammation, including ocular inflammation. In some embodiments, the methods comprise administering an expression vector that delivers a secretable and cell penetrating Nrf2 to a subject in need thereof.Type: ApplicationFiled: June 8, 2021Publication date: September 30, 2021Applicant: University of Florida Research Foundation, IncorporatedInventors: Cristhian J. Ildefonso, Alfred S. Lewin, Qiuhong Li
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Patent number: 11053291Abstract: The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or inflammation, including ocular inflammation. In some embodiments, the methods comprise administering an expression vector that delivers a secretable and cell penetrating Nrf2 to a subject in need thereof.Type: GrantFiled: February 19, 2015Date of Patent: July 6, 2021Assignee: University of Florida Research Foundation, IncorporatedInventors: Cristhian J. Ildefonso, Alfred S. Lewin, Qiuhong Li
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Patent number: 10981961Abstract: The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization.Type: GrantFiled: March 11, 2014Date of Patent: April 20, 2021Assignee: University of Florida Research Foundation, IncorporatedInventors: Cristhian J. Ildefonso, Alfred S. Lewin, Qiuhong Li
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Publication number: 20210000973Abstract: In some aspects, the disclosure relates to compositions and methods that are useful for treating inflammatory disorders and conditions. In some embodiments, the disclosure provides recombinant adeno-associated virus (rAAV) vectors and particles encoding a transgene that expresses a Myxomavirus serine proteinase inhibitor (Serp) protein (e.g., Serp-1) and methods for treating inflammatory disorders using the same.Type: ApplicationFiled: March 8, 2019Publication date: January 7, 2021Applicant: University of Florida Research Foundation, IncorporatedInventors: Alexandra Rose Lucas, Alfred S. Lewin, Cristhian J. Ildefonso
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Publication number: 20170088593Abstract: The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or inflammation, including ocular inflammation. In some embodiments, the methods comprise administering an expression vector that delivers a secretable and cell penetrating Nrf2 to a subject in need thereof.Type: ApplicationFiled: February 19, 2015Publication date: March 30, 2017Applicant: University of Florida Research Foundation, Inc.Inventors: Cristhian J. Ildefonso, Alfred S. Lewin, Qiuhong Li
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Publication number: 20160376325Abstract: Disclosed are methods and compositions for preventing, treating, and/or ameliorating one or more symptoms of inflammation in a mammal. In particular, viral vectors and medicaments containing them are disclosed, which are useful in the prophylaxis, therapy, or amelioration of symptoms of one or more inflammatory-mediated mammalian diseases, such as age-related macular degeneration (AMD), arthritis, Bechet's disease, Best macular dystrophy, corneal inflammation, diabetic retinopathy, drusen formation, dry AMD, dry eye, geographic atrophy, glaucomaocular neovascularization, Lupus erythematosus, macular degeneration, Mallatia Leventinese and Doyne honeycomb retinal dystrophy, nephritis, ocular hypertension, ocular inflammation, recurrent uveitis, Sorsby fundus dystrophy, vasculitis, vitreoretinopathy, wet AMD, or related disorders.Type: ApplicationFiled: September 9, 2016Publication date: December 29, 2016Inventors: Douglas Grant McFadden, Alfred S. Lewin, Alexandra Rose Lucas, Cristhian J. Ildefonso, Mohammed Masmudur Rahman
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Publication number: 20160017012Abstract: The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization.Type: ApplicationFiled: March 11, 2014Publication date: January 21, 2016Applicant: University of Florida Research Foundation, Inc.Inventors: Cristhian J. Ildefonso, Alfred S. Lewin, Qiuhong Li