Abstract: The present disclosure relates to an apparatus including one or more processors configured to receive a digitized image of a region of tissue demonstrating a disease, and containing cellular structures represented in the digitized image, each of the cellular structures being associated with a cell category of a plurality of cell categories; select a cellular structure of the cellular structures based on the cell category for the cellular structure; for the cellular structure selected, compute a set of contextual features; assign, based on the set of contextual features, the cellular structure to at least one cluster of a plurality of clusters; compute cluster features, the cluster features describing characteristics of the at least one cluster of the plurality of clusters; and generate a prediction that describes a pathologic or phenotypic state of the disease based, at least in part, on the cluster features and/or the set of contextual features.

Abstract: The present disclosure relates to a non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, including generating an imaging data set having both scan data and digitized biopsy data from a patient with small cell lung cancer (SCLC). Scan derived features are extracted from the scan data and biopsy derived features are extracted from the digitized biopsy data. A radiomic-pathomic risk score (RPRS) is calculated from one or more of the scan derived features and one or more of the biopsy derived features. The RPRS is indicative of a prognosis of the patient.

Abstract: Embodiments include controlling a processor to access an image of a region of tissue demonstrating cancerous pathology; segment a cellular nucleus represented in the image; extract a first set of features from the segmented cellular nucleus; classify the segmented nucleus as a lymphocyte or non-lymphocyte based on the first set of features; for a segmented nucleus classified as a lymphocyte: computing a set of contextual features; assign the segmented nucleus classified as a lymphocyte to one of a plurality of clusters based on the set of contextual features; compute a frequency distribution of the clustered segmented nuclei classified as lymphocytes; provide the frequency distribution to a machine learning classifier; receive, from the machine learning classifier, a classification of the region of tissue as likely to experience recurrence or unlikely to experience recurrence, based, at least in part, on the frequency distribution; and display the classification.

Abstract: Embodiments access a digitized image of tissue demonstrating non-small cell lung cancer (NSCLC), the tissue including a plurality of cellular nuclei; segment the plurality of cellular nuclei represented in the digitized image; extract a set of nuclear radiomic features from the plurality of segmented cellular nuclei; generate at least one nuclear cell graph (CG) based on the plurality of segmented nuclei; compute a set of CG features based on the nuclear CG; provide the set of nuclear radiomic features and the set of CG features to a machine learning classifier; receive, from the machine learning classifier, a probability that the tissue will respond to immunotherapy, based, at least in part, on the set of nuclear radiomic features and the set of CG features; generate a classification of the tissue as a responder or non-responder based on the probability; and display the classification.

Abstract: Embodiments include controlling a processor to perform operations, the operations comprising: accessing a digitized image of a region of tissue demonstrating non-small cell lung cancer (NSCLC), detecting a member of a plurality of cellular nuclei represented in the image; classifying the member of the plurality of cellular nuclei as a tumor infiltrating lymphocyte (TIL) nucleus or non-TIL nucleus; extracting spatial TIL features from the plurality of cellular nuclei, including a first subset of features based on the spatial arrangement of TIL nuclei, and a second, different subset of features based on the spatial relationship between TIL nuclei and non-TIL nuclei; generating a set of graph interplay features based on the set of spatial TIL features; providing the set of graph interplay features to a machine learning classifier; receiving, from the machine learning classifier, a probability that the region of tissue will respond to immunotherapy, based, at least in part, on the set of graph interplay features;

Abstract: Embodiments include controlling a processor to access an image of a region of tissue demonstrating cancerous pathology; segment a cellular nucleus represented in the image; extract a first set of features from the segmented cellular nucleus; classify the segmented nucleus as a lymphocyte or non-lymphocyte based on the first set of features; for a segmented nucleus classified as a lymphocyte: computing a set of contextual features; assign the segmented nucleus classified as a lymphocyte to one of a plurality of clusters based on the set of contextual features; compute a frequency distribution of the clustered segmented nuclei classified as lymphocytes; provide the frequency distribution to a machine learning classifier; receive, from the machine learning classifier, a classification of the region of tissue as likely to experience recurrence or unlikely to experience recurrence, based, at least in part, on the frequency distribution; and display the classification.

Abstract: Embodiments include controlling a processor to perform operations, the operations comprising: accessing a digitized image of a region of tissue demonstrating non-small cell lung cancer (NSCLC), detecting a member of a plurality of cellular nuclei represented in the image; classifying the member of the plurality of cellular nuclei as a tumor infiltrating lymphocyte (TIL) nucleus or non-TIL nucleus; extracting spatial TIL features from the plurality of cellular nuclei, including a first subset of features based on the spatial arrangement of TIL nuclei, and a second, different subset of features based on the spatial relationship between TIL nuclei and non-TIL nuclei; generating a set of graph interplay features based on the set of spatial TIL features; providing the set of graph interplay features to a machine learning classifier; receiving, from the machine learning classifier, a probability that the region of tissue will respond to immunotherapy, based, at least in part, on the set of graph interplay features;

Abstract: Embodiments access a digitized image of tissue demonstrating non-small cell lung cancer (NSCLC), the tissue including a plurality of cellular nuclei; segment the plurality of cellular nuclei represented in the digitized image; extract a set of nuclear radiomic features from the plurality of segmented cellular nuclei; generate at least one nuclear cell graph (CG) based on the plurality of segmented nuclei; compute a set of CG features based on the nuclear CG; provide the set of nuclear radiomic features and the set of CG features to a machine learning classifier; receive, from the machine learning classifier, a probability that the tissue will respond to immunotherapy, based, at least in part, on the set of nuclear radiomic features and the set of CG features; generate a classification of the tissue as a responder or non-responder based on the probability; and display the classification.

Abstract: An apparatus, method, and computer-readable medium for high ping rate depth sounding. The apparatus may cause transmission of a first sonar beam having a first frequency and transmission of a second sonar beam having a second frequency with a transducer assembly. The transducer assembly maybe configured to transmit the first sonar beam and the second sonar beam into the underwater environment. The apparatus may receive sonar return data from the transducer assembly beginning either simultaneously with transmission of the first sonar beam or prior to transmission of the second sonar beam. The apparatus may further determine, based on sonar return data acquired after transmission of both the first sonar beam and the second sonar beam, that the sonar return data corresponds to the first sonar beam by determining that the sonar return data comprises the first frequency.