Patents by Inventor Cristian Parisi

Cristian Parisi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240360078
    Abstract: The present disclosure pertains to iodinated compounds that comprise at least one 2,4,6-triiodobenzene moiety in which at least one of the hydrogens at 1-, 3- and 5-positions of the 2,4,6-triiodobenzene moiety is substituted by an iodinated substituent that comprises one or more iodophenyl-containing groups. The present disclosure also pertains to compositions containing such iodinated compounds and methods of making such iodinated compounds.
    Type: Application
    Filed: May 14, 2024
    Publication date: October 31, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Yiqing Tang, Francesco Cuda, Cristian Parisi, Koorosh Ashrafi, Sean L. Willis, Curry Brown
  • Publication number: 20240358896
    Abstract: In some embodiments, the present disclosure pertains to an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers. In some embodiments, the present disclosure pertains to kits that comprise a syringe preloaded with an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers. In some embodiments, the present disclosure pertains to methods of treatment comprising injecting into a subject an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers.
    Type: Application
    Filed: April 29, 2024
    Publication date: October 31, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Yen-Hao Hsu, Peijiang Wang, Cristian Parisi, Drew Carlton Wolos
  • Publication number: 20240335568
    Abstract: In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a radiopaque polysaccharide that comprises a plurality of radiopaque moieties that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide. In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a carboxylate-anion-containing polysaccharide that is ionically crosslinked by multivalent cations. In other aspects, the present disclosure pertains to kits that contain such radiopaque hydrogel compositions, to methods of treatment that comprise administering such radiopaque hydrogel compositions to patients, and to methods of making such radiopaque hydrogel compositions.
    Type: Application
    Filed: April 5, 2024
    Publication date: October 10, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Yen-Hao Hsu, Joseph Thomas Delaney, JR., Cristian Parisi, Heather Cirka, Alexis Compton
  • Publication number: 20240316220
    Abstract: In some aspects, the present disclosure pertains to systems for forming a crosslinked polymer composition, the systems comprising (a) an iodinated multifunctional compound comprising either a plurality of electron-rich dienophile-containing moieties or a plurality of electron-poor diene-containing moieties and (b) a multifunctional multi-arm polymer comprising either a plurality of electron-poor diene-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-rich dienophile-containing moieties or a plurality of electron-rich dienophile-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-poor diene-containing moieties, wherein the crosslinked polymer composition is formed by a cycloaddition reaction occurring between the iodinated multifunctional compound and the multifunctional multi-arm polymer.
    Type: Application
    Filed: March 22, 2024
    Publication date: September 26, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Yen-Hao Hsu, Joseph Thomas Delaney, JR., Cristian Parisi
  • Publication number: 20240301179
    Abstract: In some aspects, the present disclosure pertains to radiopaque crosslinked hydrogel compositions that comprise a crosslinked reaction product of (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In other aspects, the present disclosure pertains to systems for forming a hydrogel composition that comprise (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In further aspects, the present disclosure pertains to methods of treatment using such systems.
    Type: Application
    Filed: February 29, 2024
    Publication date: September 12, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Yen-Hao Hsu, Cristian Parisi, Joseph Thomas Delaney, JR.
  • Publication number: 20240293572
    Abstract: In some aspects, the present disclosure provides therapeutic-agent-releasing polyamino compounds that comprise a polyamino moiety that is covalently linked to a residue of a hydroxyl-substituted therapeutic agent by an ester bond. In various embodiments, such therapeutic-agent-releasing polyamino compounds are used to form therapeutic-agent-releasing hydrogels. In other aspects, the present disclosure provides therapeutic-agent-releasing polysaccharides that comprise a plurality of hydroxyl-substituted therapeutic agent residues that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide.
    Type: Application
    Filed: February 28, 2024
    Publication date: September 5, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Yen-Hao Hsu, Cristian Parisi, Joseph Thomas Delaney, JR.
  • Publication number: 20240218122
    Abstract: In some embodiments, the present disclosure pertains to multi-arm polymers having at least one polymer arm that comprises a reactive radiopaque end moiety. The radiopaque end moiety comprises a radiopaque dicarboxylic acid ester moiety containing one or more radiopaque atoms, wherein one of two ester groups of the radiopaque dicarboxylic acid ester moiety forms a link to the polymer arm, and wherein the other of the two ester groups of the radiopaque dicarboxylic acid ester moiety corresponds to a portion of a reactive electrophilic group. The present disclosure also pertains to methods of forming such multi-arm polymers and to hydrogels formed from such multi-arm polymers and a polyamino compound comprising a plurality of primary amine groups that form crosslinks with the multi-arm polymers. The present disclosure further pertains to methods and systems for forming such hydrogels and methods of treatment using such hydrogels.
    Type: Application
    Filed: December 29, 2023
    Publication date: July 4, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Yen-Hao Hsu, Cristian Parisi
  • Publication number: 20240189485
    Abstract: The disclosure pertains to radiopaque, unsaturated multi-arm polymers that comprise a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage. In some embodiments, the disclosure pertains to systems for forming hydrogels, which systems comprise (a) a polyamino compound and (b) a radiopaque, unsaturated multi-arm polymer that comprises a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage, wherein the one or more unsaturated groups are reactive with the amino groups of the polyamino compound. Other embodiments pertain to methods of treatment using such systems and to hydrogels formed from such systems.
    Type: Application
    Filed: November 21, 2023
    Publication date: June 13, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Cristian Parisi, Yen-Hao Hsu, JR., Joseph Thomas Delaney, JR.
  • Publication number: 20240075190
    Abstract: In some aspects, the present disclosure pertains to systems for forming a hydrogel that comprise (a) an iodinated polyamino compound and (b) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having unsaturated end groups that are reactive with amino groups of the iodinated polyamino compound. Other aspects of the present disclosure pertain to medical hydrogels that are formed by crosslinking the iodinated polyamino compound and the reactive multi-arm polymer of such systems. Further aspects of the present disclosure pertain to medical procedures that can be performed using such systems.
    Type: Application
    Filed: August 15, 2023
    Publication date: March 7, 2024
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Yen-Hao Hsu, Joseph Thomas Delaney, Jr., Cristian Parisi
  • Publication number: 20230355833
    Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1 —(C?O)—O— C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.
    Type: Application
    Filed: July 18, 2023
    Publication date: November 9, 2023
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis
  • Patent number: 11744916
    Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1—(C?O)—O—C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: September 5, 2023
    Inventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis
  • Publication number: 20230021742
    Abstract: In some embodiments, the present disclosure pertains to liquid compositions for medical use that comprise (a) a polymer, a monomer, a macromonomer, or a combination of any two or all three of the foregoing and (b) spherical metallic particles, which may comprise, for example, tantalum, tungsten, rhenium, niobium, molybdenum, and alloys of the foregoing. In some embodiments, the present disclosure pertains to medical methods that comprise administering such liquid compositions to a patient. In some embodiments, the present disclosure pertains to use of such liquid compositions as liquid embolics, fiducial markers, tissue-spacing materials, or therapeutic agent depots. In some embodiments, the present disclosure pertains to medical devices that comprise coatings formed from such liquid compositions.
    Type: Application
    Filed: July 11, 2022
    Publication date: January 26, 2023
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: David L. Burnett, Sean L. Willis, Cristian Parisi
  • Publication number: 20220242817
    Abstract: The present disclosure pertains to iodinated compounds that comprise at least one 2,4,6-triiodobenzene moiety in which at least one of the hydrogens at 1-, 3- and 5-positions of the 2,4,6-triiodobenzene moiety is substituted by an iodinated substituent that comprises one or more iodophenyl-containing groups. The present disclosure also pertains to compositions containing such iodinated compounds and methods of making such iodinated compounds.
    Type: Application
    Filed: January 11, 2022
    Publication date: August 4, 2022
    Inventors: Yiqing Tang, Francesco Cuda, Cristian Parisi, Koorosh Ashrafi, Sean L. Willis, Curry Brown
  • Publication number: 20210015963
    Abstract: The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO3H, —OPO3H2, —O—(C1-4alkyl), —O—(C1-4alkyl)OH, —O—(C1-4alkyl)R2, —O—(C2H5O)qR1—(C?O)—O—C1-4alkyl and —O—(C?O)C1-4alkyl; wherein R1 is H or C1-4 alkyl; R2 is —COOH, —SO3H, or —OPO3H2; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.
    Type: Application
    Filed: July 20, 2020
    Publication date: January 21, 2021
    Inventors: Koorosh Ashrafi, Hugh Britton, Francesco Cuda, Andrew Lennard Lewis, Cristian Parisi, Yiqing Tang, Sean Leo Willis