Abstract: The present invention refers to a new pharmaceutical composition applicable to any form, specially gel, cream and cream gel, liquid, spray, aerosol and lyophilized, used for treating colagenoses and fibrotic pathologies, such as keloids, hypertrophic scars, vasculophatic dermopaniculosis and the Dupuytren disease. The pharmaceutical composition of the present invention is of topical application, non-toxic, featuring debridant and anti-inflammatory action with a high rate of penetration through the skin.