Patents by Inventor Cristina A. Tan Hehir

Cristina A. Tan Hehir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides that block the binding of IgG to FcRn
    Patent number: 9012603
    Abstract: The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: April 21, 2015
    Assignee: Biogen Idec Hemophilia Inc.
    Inventors: Adam R. Mezo, Kevin A. McDonnell, Cristina A. Tan Hehir, Alfredo Castro
  • Peptides that block the binding of IgG to FcRn
    Patent number: 8101186
    Abstract: The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 24, 2012
    Assignee: Syntonix Pharmaceuticals, Inc.
    Inventors: Adam R. Mezo, Kevin A. McDonnell, Cristina A. Tan Hehir, Alfredo Castro
  • PEPTIDES THAT BLOCK THE BINDING OF IgG TO FcRn
    Publication number: 20110059889
    Abstract: The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.
    Type: Application
    Filed: December 18, 2009
    Publication date: March 10, 2011
    Inventors: ADAM R. MEZO, KEVIN A. MCDONNELL, CRISTINA A. TAN HEHIR, ALFREDO CASTRO
  • Methods for imaging soluble A-beta
    Patent number: 7837981
    Abstract: Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: November 23, 2010
    Assignee: General Electric Company
    Inventors: Tiberiu Mircea Siclovan, Michael Christopher Montalto, Kenneth Michael Fish, Eric Dustin Agdeppa, Cristina Tan Hehir
  • Amyloid binding assays
    Patent number: 7745222
    Abstract: Provided herein are amyloid-binding assays that simulate in situ brain conditions by combining binders with various A-beta species on mammalian brain tissue. In general the amyloid-binding assays comprise the steps of (a) contacting a mammalian brain tissue sample with at least one A-beta species; (b) applying a putative binder to the brain tissue sample; and (c) determining whether the putative binder binds to the A-beta species.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: June 29, 2010
    Assignee: General Electric Company
    Inventors: Kenneth Michael Fish, Cristina Tan Hehir, Michael Christopher Montalto, Eric Dustin Agdeppa
  • Agents for imaging soluble a-beta
    Patent number: 7727511
    Abstract: Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: June 1, 2010
    Assignee: General Electric Company
    Inventors: Tiberiu Mircea Siclovan, Michael Christopher Montalto, Tun Chiao Hubert Lam, Eric Dustin Agdeppa, Amy Casey Williams, Cristina Tan Hehir
  • Amyloid binding assays
    Publication number: 20080274473
    Abstract: Provided herein are amyloid-binding assays that simulate in situ brain conditions by combining binders with various A-beta species on mammalian brain tissue. In general the amyloid-binding assays comprise the steps of (a) contacting a mammalian brain tissue sample with at least one A-beta species; (b) applying a putative binder to the brain tissue sample; and (c) determining whether the putative binder binds to the A-beta species.
    Type: Application
    Filed: October 13, 2006
    Publication date: November 6, 2008
    Inventors: Kenneth Michael Fish, Cristina Tan Hehir, Michael Christopher Montalto, Eric Dustin Agdeppa