Patents by Inventor Cristina Abucay Tan Hehir
Cristina Abucay Tan Hehir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230364269Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.Type: ApplicationFiled: July 11, 2023Publication date: November 16, 2023Inventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Victoria Eugenia Cotero
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Patent number: 11730830Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.Type: GrantFiled: August 14, 2020Date of Patent: August 22, 2023Assignee: General Electric CompanyInventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Victoria Eugenia Cotero
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Publication number: 20210015946Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.Type: ApplicationFiled: August 14, 2020Publication date: January 21, 2021Inventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Victoria Eugenia Cotero
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Patent number: 10744212Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.Type: GrantFiled: March 14, 2016Date of Patent: August 18, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Victoria Eugenia Cotero
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Publication number: 20170258941Abstract: The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.Type: ApplicationFiled: March 14, 2016Publication date: September 14, 2017Inventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Victoria Eugenia Cotero
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Patent number: 9040019Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.Type: GrantFiled: November 30, 2012Date of Patent: May 26, 2015Assignee: General Electric CompanyInventors: Tiberiu Mircea Siclovan, Cristina Abucay Tan Hehir, Rong Zhang, Victoria Eugenia Cotero, Anshika Bajaj
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Patent number: 8977331Abstract: Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image.Type: GrantFiled: December 13, 2012Date of Patent: March 10, 2015Assignee: General Electric CompanyInventors: Evgenia Mikhailovna Kim, Siavash Yazdanfar, Cristina Abucay Tan Hehir
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Publication number: 20140171764Abstract: Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image.Type: ApplicationFiled: December 13, 2012Publication date: June 19, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Evgenia Mikhailovna Kim, Siavash Yazdanfar, Cristina Abucay Tan Hehir
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Publication number: 20140154178Abstract: A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.Type: ApplicationFiled: November 30, 2012Publication date: June 5, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Tiberiu Mircea Siclovan, Cristina Abucay Tan Hehir, Rong Zhang, Victoria Eugenia Cotero, Anshika Bajaj
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Patent number: 8658129Abstract: The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, administering to a subject an agent that binds specifically to myelin basic protein, and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.Type: GrantFiled: February 21, 2011Date of Patent: February 25, 2014Assignee: General Electric CompanyInventors: Rong Zhang, Tiberiu Mircea Siclovan, Cristina Abucay Tan Hehir, Victoria Eugenia Cotero, Bruce Fletcher Johnson
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Patent number: 8617515Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.Type: GrantFiled: June 4, 2009Date of Patent: December 31, 2013Assignee: General Electric CompanyInventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Nicole Evelyn Barnhardt, Kenneth Michael Fish, Randall Lee Carter, Bruce Fletcher Johnson
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Patent number: 8357350Abstract: The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a 13C or 2H enriched compound of Formula I, an 19F-labeled derivative of Formula I, a metal-DOTA (1,4,7,10-tetra-azacyclododecane-N,N?,N?,N??-tetraacetic acid) complex of Formula I, or a radioisotope derivative of Formula I.Type: GrantFiled: February 12, 2009Date of Patent: January 22, 2013Assignee: General Electric CompanyInventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Kenneth Michael Fish, Nicole Evelyn Barnhardt, John V. Frangioni, Carrie S. Vooght
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Patent number: 8169696Abstract: Disclosed are systems for intraoperative nerve imaging using compact high collection power imaging devices for fluorescence and white light imaging of myelin basic protein (MBP) nerve imaging agents during open and minimally invasive surgery.Type: GrantFiled: June 23, 2010Date of Patent: May 1, 2012Assignee: General Electric CompanyInventors: Siavash Yazdanfar, Cristina Abucay Tan Hehir, Xinghua Wang
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Patent number: 8114382Abstract: The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site.Type: GrantFiled: September 17, 2008Date of Patent: February 14, 2012Assignee: General Electric CompanyInventors: Cristina Abucay Tan Hehir, Stephen Johnson Lomnes, Kenneth Michael Fish, Tiberiu Mircea Siclovan, Michael Christopher Montalto, Tunchiao Hubert Lam
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Publication number: 20110142759Abstract: The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, administering to a subject an agent that binds specifically to myelin basic protein, and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.Type: ApplicationFiled: February 21, 2011Publication date: June 16, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Rong Zhang, Tiberiu Mircea Siclovan, Cristina Abucay Tan Hehir, Victoria Eugenia Cotero, Bruce Fletcher Johnson
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Publication number: 20100310456Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein.Type: ApplicationFiled: January 27, 2010Publication date: December 9, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Tiberiu Mircea Siclovan, Bruce Fletcher Johnson, Rong Zhang, Cristina Abucay Tan Hehir
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Publication number: 20100310457Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein.Type: ApplicationFiled: June 4, 2009Publication date: December 9, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Nicole Evelyn Barnhardt, Kenneth Michael Fish, Randall Lee Carter, Bruce Fletcher Johnson
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Publication number: 20100312122Abstract: Disclosed are systems for intraoperative nerve imaging using compact high collection power imaging devices for fluorescence and white light imaging of myelin basic protein (MBP) nerve imaging agents during open and minimally invasive surgery.Type: ApplicationFiled: June 23, 2010Publication date: December 9, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Siavash Yazdanfar, Cristina Abucay Tan Hehir, Xinghua Wang
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Publication number: 20100202965Abstract: The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a 13C or 2H enriched compound of Formula I, an 19F-labeled derivative of Formula I, a metal-DOTA (1,4,7,10-tetra-azacyclododecane-N,N?,N?,N??-tetraacetic acid) complex of Formula I, or a radioisotope derivative of Formula I.Type: ApplicationFiled: February 12, 2009Publication date: August 12, 2010Applicant: General Electric CompanyInventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Kenneth Michael Fish, Nicole Evelyn Barnhardt, John V. Frangioni, Carrie S. Vooght
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Publication number: 20090234236Abstract: A method of visualizing nerves by observing the hemodynamic response of the blood flow comprising: acquiring a pre-stimulus image of a target tissue; providing a stimulus to the target tissue; introducing a time delay between the stimulus and a post-stimulus image; capturing the post-stimulus image of the target tissue; and producing a processed image based on a comparison between the pre-stimulus image and the post-stimulus image. Also described is a system for evaluating the hemodynamic response of blood flow comprising producing a processed image based on a comparison between the pre-stimulus image and the post-stimulus image.Type: ApplicationFiled: March 14, 2008Publication date: September 17, 2009Applicant: General Electric CompanyInventors: Stephen Johnson LOMNES, Cristina Abucay TAN HEHIR, Deborah Stutz LEE