Abstract: Peptide tags (tags) are provided for their fusion to proteins at the N-terminal or C-terminal ends, which are defined by a series of structural and functional properties that define their safety with regard to the modification of the structure or biological function of the protein or peptide to which they are fused, and wherein the tag-protein is selected from a group consisting of a fragment of Phl P 2 Pheleum pratense , a fragment of Hev b 6.02 Hevea brasiliensis, and a fragment of Amb t 5 Ambrosia trifida, or a combination thereof. Methods are also provided for the production and detection of these recombinant fusion proteins as well as specific antibodies that bind to these tags.