Patents by Inventor Cristina MANGUAN GARCÍA

Cristina MANGUAN GARCÍA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RELEASE OF SUBSTANCES IN SENESCENT CELLS
    Publication number: 20190274956
    Abstract: The invention relates to nanodevices for the controlled release of substances which comprises a support coated in oligosaccharides, wherein said oligosaccharides comprise at least 3 units of monosaccharides, and wherein at least one of the monosaccharides is galactose. These nanodevices release their load specifically in senescent cells. The invention also encompasses the method of obtainment and its uses.
    Type: Application
    Filed: May 7, 2019
    Publication date: September 12, 2019
    Inventors: Ramón Martínez Máñez, José Ramón Murguia Ibáñez, Rosario Perona Abellón, Alessandro Agostini, Laura Mondragón Martínez, Marta Moreno Torres, Cristina Manguan García, María Dolores Marcos Martínez, Juan Soto Camino, Felíx Sancenón Galarza
  • PEPTIDES DERIVED FROM GSE 24.2 FOR TREATING DISEASES CAUSED BY OXIDATIVE STRESS AND DAMAGE TO DNA
    Publication number: 20160340656
    Abstract: This invention relates to a polypeptide which comprises the fragment SEQ ID No. 2 of peptide GSE24.2 (SEQ ID No. 1) and can reduce the production of free radicals and/or damage to the DNA structure of a cell, optionally comprising nuclear localisation sequences. The invention also relates to a polynucleotide and to a vector, which comprise sequences coding for said polypeptide, and to a pharmaceutical composition comprising said polypeptide, polynucleotide and/or vector. The invention further relates to the applications of the polypeptide such as the use thereof for treating and/or preventing diseases caused by an increase in oxidative stress and/or damage to cellular DNA, such as ataxia-telangiectasia or dyskeratosis congenita, or the use thereof in tissue engineering and cell culture for increasing the viability of same.
    Type: Application
    Filed: October 24, 2014
    Publication date: November 24, 2016
    Inventors: Rosario PERONA ABELLÓN, Leandro SASTRE GARZÓN, Laura PINTADO BERNINCHES, Jaime CARRILLO GARCÍA, Antonio MOLINA PACHÓN, Laura IRRADICCIO SILVA, Cristina MANGUAN GARCÍA
  • Biodegradable Bionanoparticles for Releasing the GSE24-2 Peptide, Method for the Production Thereof, and Use of Same
    Publication number: 20160051485
    Abstract: The invention relates to biodegradable PLGA bionanoparticles encapsulating the GSE24-2 peptide with telomerase activity and to pharmaceutical, cosmetic and biotechnological compositions comprising same. The pharmaceutical compositions are useful for treating diseases presenting a telomerase deficiency, such as dyskeratosis congenita, and diseases presenting ageing characteristics, such as Werner syndrome, Rothmund Thompson syndrome, and other diseases where there is DNA damage such as ataxia telangiectasia. The invention likewise relates to the method for producing said bionanoparticles by means of a w/o/w double emulsion technique.
    Type: Application
    Filed: February 3, 2014
    Publication date: February 25, 2016
    Inventors: Rosario Perona Abellon, Jose Luis Pedraz Munoz, Rosa Maria Hernandez Martin, Manuela Igartua Olaechea, Susana Eguskiaguirre Martin, Cristina Manguan Garcia
  • RELEASE OF SUBSTANCES IN SENESCENT CELLS
    Publication number: 20150306037
    Abstract: The invention relates to nanodevices for the controlled release of substances which comprises a support coated in oligosaccharides, wherein said oligosaccharides comprise at least 3 units of monosaccharides, and wherein at least one of the monosaccharides is galactose. These nanodevices release their load specifically in senescent cells. The invention also encompasses the method of obtainment and its uses.
    Type: Application
    Filed: August 6, 2013
    Publication date: October 29, 2015
    Inventors: Ramón MARTÍNEZ MÁÑEZ, José Ramón MURGUIA IBÁÑEZ, Rosario PERONA ABELLÓN, Alessandro AGOSTINI, Laura MONDRAGÓN MARTÍNEZ, Marta MORENO TORRES, Cristina MANGUAN GARCÍA, María Dolores MARCOS MARTÍNEZ, Juan SOTO CAMINO, Félix SANCENÓN GALARZA