Abstract: Disclosed is a pontoon (111) for transporting and placing a one-piece marine wind turbine (115) on the seabed, wherein the one-piece wind turbine (115) comprises a base caisson (116) that can be fitted inside the open space of the U-shaped pontoon (111) for transporting, positioning and placing the base caisson (116) of the marine wind turbine (115) on the seabed, by ballasting the base caisson (116) and the U-shaped pontoon (111) in a synchronised manner using seawater.

Abstract: A microfluidic platform is provided for controlling and configuring the evolution of a gradient. The microfluidic platform includes a plate having an outer surface and defining a chamber therein for receiving cells and/or drug/reagent particles of interest captured within a polymerized material. A plurality of wells are adapted for receiving a one or more types of desired media to form gradients in the polymerized material. The plurality of wells have first portions communicating with the outer surface of the plate and second portions communicating with the chamber. The first and second portions of the plurality of wells having corresponding widths and cross-sectional areas, and each of the plurality of wells is spaced from an adjacent well of the plurality of wells by a distance.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein X1, R1, R2, R3, R4, R5, R6, R6?, R7, R7?, R8, R9, R9?, R10, R11, R12, and n are described herein.

Abstract: According to an embodiment, a receiver is described comprising an input configured to receive a digital input signal and a digital filter configured to deliver a filtered digital output signal and to deliver stability information wherein the digital filter is configured to enter or stay in a transition state after a transition at the input signal, leave the transition state when the input signal is considered being stable, update the output signal when leaving the transition state and deliver the stability information indicating transitions at the input signal during transition state.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

Abstract: Techniques for dewatering thick fine tailings may include flocculant dosing on a clay basis and then subjecting the flocculated tailings to dewatering, for instance by pipelining the flocculated material from flocculant addition to a deposition site. The thick fine tailings can be pre-treated by removing hydrocarbons and shear-thinning prior to flocculant addition.

Abstract: According to an embodiment, a receiver is described comprising an input configured to receive a digital input signal and a digital filter configured to deliver a filtered digital output signal and to deliver stability information wherein the digital filter is configured to enter or stay in a transition state after a transition at the input signal, leave the transition state when the input signal is considered being stable, update the output signal when leaving the transition state and deliver the stability information indicating transitions at the input signal during transition state.

Abstract: The invention generally relates to diagnostic, prognostic, and monitoring methods and assays for breast cancer and kits that may be used in such methods. More particularly, the invention relates to a method of prognosis of a patient afflicted with breast cancer, including determining the level of HER2/CB2 heteromer expression in a biological sample obtained from the patient.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

Abstract: A process for dewatering oil sand fine tailings is provided and comprises a dispersion and floc build-up stage comprising in-line addition of a flocculent solution comprising an effective amount of flocculation reagent into a flow of the oil sand fine tailings; a gel stage wherein flocculated oil sand fine tailings is transported in-line and subjected to shear conditioning; a floc breakdown and water release stage wherein the flocculated oil sand fine tailings releases water and decreases in yield shear stress, while avoiding an oversheared zone; depositing the flocculated oil sand fine tailings onto a deposition area to form a deposit and to enable the release water to flow away from the deposit, preferably done in a pipeline reactor and managing shear according to yield stress and CST information and achieves enhanced dewatering.

Abstract: A method of starting a gas turbine and related apparatus, the method including keeping a main fuel line in a sealed state while allowing fuel to flow from a fuel source to at least one nozzle of a nozzle array via an auxiliary fuel line; firing a gas turbine while keeping the main fuel line in the sealed state; and after combustion has started: opening the main fuel line to commence a flow of fuel from the fuel source to the at least one nozzle of the nozzle array via the main fuel line, sealing the auxiliary fuel line, and after the auxiliary fuel line is sealed, increasing the flow of fuel from the fuel source to the at least one nozzle of the nozzle array via the main fuel line.

Abstract: A process for dewatering oil sand fine tailings is provided and comprises a dispersion and floc build-up stage comprising in-line addition of a flocculent solution comprising an effective amount of flocculation reagent into a flow of the oil sand fine tailings; a gel stage wherein flocculated oil sand fine tailings is transported in-line and subjected to shear conditioning; a floc breakdown and water release stage wherein the flocculated oil sand fine tailings releases water and decreases in yield shear stress, while avoiding an oversheared zone; depositing the flocculated oil sand fine tailings onto a deposition area to form a deposit and to enable the release water to flow away from the deposit, preferably done in a pipeline reactor and managing shear according to yield stress and CST information and achieves enhanced dewatering.

Abstract: The invention generally relates to diagnostic, prognostic, and monitoring methods and assays for breast cancer and kits that may be used in such methods. More particularly, the invention relates to a method of prognosis of a patient afflicted with breast cancer, including determining the level of HER2/CB2 heteromer expression in a biological sample obtained from the patient.

Abstract: A process for dewatering oil sand fine tailings is provided and comprises a dispersion and floc build-up stage comprising in-line addition of a flocculent solution comprising an effective amount of flocculation reagent into a flow of the oil sand fine tailings; a gel stage wherein flocculated oil sand fine tailings is transported in-line and subjected to shear conditioning; a floc breakdown and water release stage wherein the flocculated oil sand fine tailings releases water and decreases in yield shear stress, while avoiding an oversheared zone; depositing the flocculated oil sand fine tailings onto a deposition area to form a deposit and to enable the release water to flow away from the deposit, preferably done in a pipeline reactor and managing shear according to yield stress and CST information and achieves enhanced dewatering.

Abstract: A process for dewatering oil sand fine tailings is provided and comprises a dispersion and floc build-up stage comprising in-line addition of a flocculent solution comprising an effective amount of flocculation reagent into a flow of the oil sand fine tailings; a gel stage wherein flocculated oil sand fine tailings is transported in-line and subjected to shear conditioning; a floc breakdown and water release stage wherein the flocculated oil sand fine tailings releases water and decreases in yield shear stress, while avoiding an oversheared zone; depositing the flocculated oil sand fine tailings onto a deposition area to form a deposit and to enable the release water to flow away from the deposit, preferably done in a pipeline reactor and managing shear according to yield stress and CST information and achieves enhanced dewatering.

Abstract: Techniques for dewatering thick fine tailings may include one or more pre-treatment steps, such as pre-shearing to reduce the yield stress prior to flocculation, hydrocarbon removal below a threshold to improve flocculation and dewatering, flocculant dosing on a clay basis, and providing certain properties of the thick fine tailings related to coarse and fine particle sizes and/or chemistry such as divalent cation content. Various advantages may result from pre-treatments based on thick fine tailings properties, such as reduced flocculant dosage requirements, improved dispersion of flocculant into the thick fine tailings and/or enhanced dewatering, for example. One or more of the pre-treatments may be performed.

Abstract: The present invention relates to phytocannabinoids for use in the treatment of a breast cancer. In a first embodiment the invention relates to an oral presentation of tetrahydrocannabinol (THC) for use in the treatment of aggressive breast cancer, characterised by overexpression of the Her2 gene. In a second embodiment the invention relates to the phytocannabinoid cannabidiol (CBD) for use in the treatment of aggressive breast cancer, characterised by overexpression of the Her2 gene. In a third embodiment the invention relates to the combination of the phytocannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) for use in the treatment of breast cancer or to treat, prevent or to reduce the risk of a cancer metastasising.

Abstract: The present invention relates to novel smart packaging, designed using a novel material comprising a partially polar adsorbent solid base impregnated with a solution of vanillin, which allows the growth of microorganisms in different types of products to be detected visually without having to be in direct contact with the microorganism or with the medium containing same.

Abstract: The invention concerns freezable dairy compositions comprising milk, processes for making such compositions and for freezing them, and their uses. The composition has an overrun of from 25% to 150%.

Abstract: A process for dewatering oil sand fine tailings is provided and comprises a dispersion and floc build-up stage comprising in-line addition of a flocculent solution comprising an effective amount of flocculation reagent into a flow of the oil sand fine tailings; a gel stage wherein flocculated oil sand fine tailings is transported in-line and subjected to shear conditioning; a floc breakdown and water release stage wherein the flocculated oil sand fine tailings releases water and decreases in yield shear stress, while avoiding an oversheared zone; depositing the flocculated oil sand fine tailings onto a deposition area to form a deposit and to enable the release water to flow away from the deposit, preferably done in a pipeline reactor and managing shear according to yield stress and CST information and achieves enhanced dewatering.