Patents by Inventor Cristobal M. Roldan

Cristobal M. Roldan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors
    Patent number: 5183821
    Abstract: N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide (amonafide) is an effective agent for the treatment of leukemias and solid tumors.
    Type: Grant
    Filed: July 8, 1991
    Date of Patent: February 2, 1993
    Assignee: Laboratories Knoll, S.A.
    Inventors: Miguel F. Brana, Antonio M. Sanz, Rafael P. Alvarez-Ossorio, Cristobal M. Roldan, Cristina R. F. De Gamboa, Jesus G. Garcia, Jose M. C. Berlanga
  • N(Aminoalkyl)-naphthalimides and their derivatives
    Patent number: 4204063
    Abstract: N-substituted-3-substituted naphthalimides are prepared by reacting 3-substituted naphthalic acid with a compound having a primary amino group. The naphthalimides possess cytotoxic properties.
    Type: Grant
    Filed: June 2, 1978
    Date of Patent: May 20, 1980
    Assignee: Laboratorios Made, S.A.
    Inventors: Miguel F. Brana, Antonio M. Sanz, Rafael P. Alvarez-Ossorio, Cristobal M. Roldan, Cristina R. Fernandez de Gamboa
  • 2-(2-Furoyl)-4-methylpyridine and its methyl iodide quaternary salt
    Patent number: 4173705
    Abstract: 2-Cyano-4-methylpyridine is reacted in an inert atmosphere with an ethereal solution of freshly prepared 2-furoyl-lithium followed by acid hydrolysis to form 2-(2-furoyl)-4-methylpyridine which is then reacted with methyl iodide to form 2-(2-furoyl)-1,4-dimethylpyridinium iodide. Both furoyl compounds exhibit thermal and chemical analgesic properties.
    Type: Grant
    Filed: October 6, 1978
    Date of Patent: November 6, 1979
    Assignee: Laboratorios Made, S.A.
    Inventors: Ricardo G. Jarque, Juan B. Cartes, Rosa L. Jimenez, Cristobal M. Roldan, Fernando R. Peinado
  • 3-Thienyl-3-methyl-4-pentyl-2-pyridyl-ketone
    Patent number: 4172894
    Abstract: 3-Thienyl-3-methyl-4-pentyl-2-pyridyl-ketone of the formula: ##STR1## useful as an analgesic and a process for its preparation are disclosed.
    Type: Grant
    Filed: June 14, 1978
    Date of Patent: October 30, 1979
    Assignee: Laboratories Made, S.A.
    Inventors: Ricardo G. Jarque, Juan B. Cartes, Francisco L. Calahorra, Cristobal M. Roldan, Fernando R. Peinado
  • Alpha-2,5,9-trimethyl-benzo(b)thiene(2,3-f)morphan and precursor thereof
    Patent number: 4172201
    Abstract: Alpha-2,5,9-trimethyl-benzo [b]thiene [2,3-f]morphan and 2-(3-benzo[b]thienylmethyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine or their pharmacologically acceptable acid addition salts are useful as analgesic agents.
    Type: Grant
    Filed: February 2, 1978
    Date of Patent: October 23, 1979
    Assignee: Laboratorios Made, S.A.
    Inventors: Ricardo G. Jarque, Mercedes A. Domingo, Juan B. Cartes, Cristobal M. Roldan, Fernando R. Peinado
  • N-Aminoethyl-substituted-3-nitronaphthalimides
    Patent number: 4146720
    Abstract: Compounds having the formula ##STR1## wherein Y is 2-dimethylaminoethyl, 2-diethylaminoethyl, 2-(N-pyrrolidino)ethyl or 2-(N-piperidino)ethyl. The compounds are prepared by reacting 3-nitronaphthalic acid, or corresponding anhydride, with the corresponding primary amine. The compounds possess cytostatic and raticide properties.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: March 27, 1979
    Assignee: Laboratorios Made, S.A.
    Inventors: Cristobal M. Roldan, Miguel F. Brana, Jose M. C. Berlanga
  • 1,4,4A-Trimethyl-1,2,4a,-4b,9a,10a-hexahydro-10H-benzo ?b! thieno ?2',3':4,3!cyclopent-?1,2-b!-pyridine
    Patent number: 4145424
    Abstract: The compound 1,4,4a-trimethyl-1,2,4a,4b,9a,10a-hexahydro-10H benzo ?b! thieno ?2',3':4,3! cyclopent ?1,2-b!-pyridine of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof is disclosed as an analgesic compound.
    Type: Grant
    Filed: March 14, 1978
    Date of Patent: March 20, 1979
    Assignee: Laboratorios Made, S.A.
    Inventors: Ricardo G. Jarque, Mercedes A. Domingo, Juan Bosch Cartes, Cristobal M. Roldan, Fernando R. Peinado