Abstract: The present invention provides methods for inducing rapid and significant dilation of a subject's pupils. In certain embodiments, the method comprises upregulating the alpha-1 receptors in the eye of the subject, thereby increasing sensitivity to alpha-1 agonists. In other embodiments, such upregulation is achieved through administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists for a period of time prior to the intended time of dilation. After inducing the upregulation of alpha-1 receptors through the administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists, alpha-1 agonists can be administered to induce rapid and strong pupil dilation.

Abstract: The present invention provides methods for inducing or enhancing rapid and significant dilation of a subject's pupils. In certain embodiments, the method comprises upregulating the alpha-1 receptors in the eye of the subject, thereby increasing sensitivity to alpha-1 agonists. In other embodiments, such upregulation is achieved through administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists for a period of time prior to the intended time of dilation. After inducing the upregulation of alpha-1 receptors through the administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists, alpha-1 agonists can be administered to induce or enhance rapid and strong pupil dilation.

Abstract: Various embodiments of the present technology generally relate to treatment for dry eyes. More specifically, some embodiments of the present technology relate to eyeglass frames for treatment of dry eye syndrome and corresponding three-dimensional printing systems and methods. In some embodiments an eyewear apparatus includes a frame with a seal configured to engage with the skin of the wearer around a majority of the perimeter of an interior portion of the front of the frame sufficient to keep the humidity around the eye high enough to provide relief from symptoms of dry eye syndrome.

Abstract: Apparatus and methods for cataract extraction are disclosed. An extraction device may include a delivery shaft having a lumen and a distal end. The lumen may include a first channel and a second channel diverging at the distal end. A wire may form a loop and extend from the first channel and the second channel. The wire may be movable within the lumen.

Abstract: The present invention provides methods for inducing or enhancing rapid and significant dilation of a subject's pupils. In certain embodiments, the method comprises upregulating the alpha-1 receptors in the eye of the subject, thereby increasing sensitivity to alpha-1 agonists. In other embodiments, such upregulation is achieved through administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists for a period of time prior to the intended time of dilation. After inducing the upregulation of alpha-1 receptors through the administration of at least one compound selected from the group consisting of alpha-2 selective agonists and beta adrenoreceptor antagonists, alpha-1 agonists can be administered to induce or enhance rapid and strong pupil dilation.

Abstract: A bottle opener comprising a carabiner frame with an inwardly opening pivoting gate on a first side of the frame and an appendage comprising an area engagable with an underside of a bottle cap. The appendage protrudes into a space within the carabiner frame from a point on an interior of a second side of the frame opposite the first side. When the gate is opened, a free end of the gate fits under the appendage.