Patents by Inventor Csaba Huszar
Csaba Huszar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160272606Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (VI), or a salt thereof and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (VI) and process for the preparation thereof.Type: ApplicationFiled: June 1, 2016Publication date: September 22, 2016Inventors: Csaba HUSZÁR, Adrienn HEGEDUS, Zsolt DOMBRÁDY
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Patent number: 9382223Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof (formula I), which comprises oxidizing a compound of formula (VI), or a salt thereof and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (VI) and process for the preparation thereof.Type: GrantFiled: February 14, 2013Date of Patent: July 5, 2016Assignee: SANOFIInventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
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Patent number: 9249119Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (IV) or a salt thereof with an oxidizing agent in an organic or inorganic solvent or solvent mixture, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (IV), and a process for the preparation thereof.Type: GrantFiled: February 1, 2013Date of Patent: February 2, 2016Assignee: SANOFIInventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
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Patent number: 9238636Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof, which comprises reacting of compound of formula (IV) with compound of formula (VI) in a Grignard reaction, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and processes for the preparation thereof.Type: GrantFiled: May 23, 2013Date of Patent: January 19, 2016Assignee: SANOFIInventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
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Publication number: 20160009678Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof (formula I), which comprises oxidizing a compound of formula (VI), or a salt thereof and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (VI) and process for the preparation thereof.Type: ApplicationFiled: February 14, 2013Publication date: January 14, 2016Applicant: SANOFIInventors: Csaba HUSZÁR, Adrienn HEGEDUS, Zsolt DOMBRÁDY
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Patent number: 9193703Abstract: The invention relates to a novel process for preparation of N-[2-n-butyl-3-[4-[3-(di-n-butylamino)-propoxy]-benzoyl]-benzofuran-5-yl]methanesulfonamide (I) and pharmaceutical acceptable salts thereof, where a salt of (5-amino-2-butyl-1-benzofuran-3-yl){4-[3-(di-n-butylamino)propoxy]phenyl}methanone of formula (II)—where A is a mono- or dibasic acid forming an acid addition salt with the compound of formula (II), n is 1 if A is dibasic acid and n is 1 or 2 if A is a monobasic acid—is reacted with a mesylating reagent in a heterogen reaction, if desired, in the presence of a phase transfer catalyst. The invention also relates to the novel salts of compound of formula (II), for the preparation thereof and their use in the preparation of dronedarone.Type: GrantFiled: March 27, 2012Date of Patent: November 24, 2015Assignee: SANOFIInventors: Antal Friesz, Csaba Huszar
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Publication number: 20150274688Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof, which comprises reacting of compound of formula (IV) with compound of formula (VI) in a Grignard reaction, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and processes for the preparation thereof.Type: ApplicationFiled: May 23, 2013Publication date: October 1, 2015Inventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
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Patent number: 9024046Abstract: The invention relates to a novel process for preparation of drohedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that a compound of formula (II) is reacted in the presence of a reductive agent with butyraldehyde and/or butanoic acid, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some hovel intermediary compounds and the preparation thereof.Type: GrantFiled: March 27, 2012Date of Patent: May 5, 2015Assignee: SanofiInventors: Antal Friesz, Csaba Huszar
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Publication number: 20150031902Abstract: The invention relates to a novel process for the preparation of dronedarone (I) and pharmaceutically acceptable salts thereof which comprises oxidizing a compound of formula (IV) or a salt thereof with an oxidizing agent in an organic or inorganic solvent or solvent mixture, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. Further aspects of the invention include the novel intermediary compound of formula (IV), and a process for the preparation thereof.Type: ApplicationFiled: February 1, 2013Publication date: January 29, 2015Applicant: SANOFIInventors: Csaba Huszár, Adrienn Hegedus, Zsolt Dombrády
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Patent number: 8816103Abstract: The subject of the invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-di-n-butylamino)-propoxy]benzoyl}benzofuran-5-yl]-methanesulfonamide of formula I: and pharmaceutically acceptable salts thereof wherein the acyl group of the benzofuran derivative of the general formula II: where R represents C1-4 alkyl-, C1-4 alkoxy- or aryl group, is selectively cleaved and if desired, the resulting compound of formula I is transformed into its salt.Type: GrantFiled: January 14, 2013Date of Patent: August 26, 2014Assignee: SanofiInventors: Antal Friesz, Csaba Huszar
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Publication number: 20140081035Abstract: The invention relates to a novel process for preparation of N-[2-n-butyl-3-[4-[3-(di-n-butylamino)-propoxy]-benzoyl]-benzofuran-5-yl]methanesulfonamide (I) and pharmaceutical acceptable salts thereof, where a salt of (5-amino-2-butyl-1-benzofuran-3-yl) {4-[3-(di-n-butylamino)propoxy]phenyl}methanone of formula (II)—where A is a mono- or dibasic acid forming an acid addition salt with the compound of formula (II), n is 1 if A is dibasic acid and n is 1 or 2 if A is a monobasic acid—is reacted with a mesylating reagent in a heterogen reaction, if desired, in the presence of a phase transfer catalyst. The invention also relates to the novel salts of compound of formula (II), for the preparation thereof and their use in the preparation of dronedarone.Type: ApplicationFiled: March 27, 2012Publication date: March 20, 2014Applicant: SANOFIInventors: Antal Friesz, Csaba Huszar
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Publication number: 20140018554Abstract: The invention relates to a novel process for preparation of drohedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that a compound of formula (II) is reacted in the presence of a reductive agent with butyraldehyde and/or butanoic acid, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some hovel intermediary compounds and the preparation thereof.Type: ApplicationFiled: March 27, 2012Publication date: January 16, 2014Applicant: SANOFIInventors: Antal Friesz, Csaba Huszar
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Patent number: 6239286Abstract: Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that: a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group and the resulting compound of formula (II) is transformed in the presence of an oxidising agent in a reaction medium with pH above 7, into the compound of formula (I), or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, orType: GrantFiled: May 15, 2000Date of Patent: May 29, 2001Assignee: Sanofi-SynthelaboInventors: Attila Kis-Tamás, Csaba Huszár, Bertrand Castro, Attila Németh, Péter Aranyosi, Károly Gyüre, István Mészáros, Ilona Dervalicsné Zrínyi, Katalin Dubovszki, Lajosné Páli, Antal Gajáry, Attila Supic, Zsuzsanna Nád, Zoltán Makovi, Endre Kollár, Zsuzsanna Csetriné Hári, Ágnes Kunsztné Kárász, Erzsébet Bognár
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Patent number: 6211382Abstract: Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group, and the resulting compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I) or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, or the compounds of formula (I) are liberated from their acid addition salts.Type: GrantFiled: April 13, 2000Date of Patent: April 3, 2001Assignee: Sanofi-SynthelaboInventors: Csaba Huszár, Attila Kis-Tamás, Attila Németh, Zsuzsanna Nád, Zoltán Makovi, Antal Gajáry, Endre Kollár, Péter Aranyosi, Károly Gyüre, István Mészáros, Zsuzsanna Csetriné Hári, Attila Supic, Ilona Dervalicsne Zrinyi, Katalin Dubovszki, Lajosné Páli, Ágnes Kunsztné Kárász, Erzsébet Bognár
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Patent number: 6162923Abstract: The present invention relates to a process for the preparation of a compound of general formula (I), ##STR1## wherein R.sup.1 represents a hydrogen atom or an alkyl group of 1-6 carbon atoms, and their salts, wherein the compound of formula (II): ##STR2## is reacted with a compound of formula (III): ##STR3## wherein R represents an alkyl group of 1-4 carbon atoms and R.sup.1 is the same as defined above, by heating their neutral pH mixtures at the boiling temperature of the mixture, and the resulting compound of general formula (IV): ##STR4## wherein R and R.sup.1 are the same as defined above, is cyclized into the compound of general formula (I) by further elevating the temperature of the neutral mixture, and if desired, the compounds of general formula (I) are transformed into their salts, or the compounds of general formula (I) are liberated from their salts.Type: GrantFiled: April 26, 2000Date of Patent: December 19, 2000Assignee: Sanofi-SynthelaboInventors: Csaba Huszar, Attila Kis-Tamas, Attila Nemeth, Antal Gajary, Lajosne Pali
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Patent number: 5648498Abstract: A process is described for the preparation of 4-Methyl-5-(2-Chloroalkyl)-thiazole wherein the alkyl ranges from C.sub.2 -C.sub.5, by providing the steps of either a) converting the 3-thiocyanato-5-chloro-2-alkanone into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole by gaseous hydrochloric acid in an organic solvent and hydrogenating the compound in the presence of a metal catalyst in an organic solvent, or b) reacting 3-thiocyanato-5-choro-2-alkanone with aqueous mineral acid and treating the thiazole obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole in an organic solvent in presence of a metal catalyst.Type: GrantFiled: June 27, 1994Date of Patent: July 15, 1997Assignee: Astra AktiebolagInventors: Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szvoboda nee Kanzel, Gergely Heja, Pal Kiss, Csaba Gonczi, Ferenc Sperber, Csaba Huszar, Gyorgy Mihalovics, Attila Nemeth, Mihaly Sut, Karol Gyure, Istvan Bone, Ferenc Morasz, Laszlo Ledniczky, Erzsebet Szabo nee Kardos, Peter Gyri, Erzsebet Szalay, Karoly Ban, Ildiko Buttkai, Arpad Kvari, Sandor Garaczy
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Patent number: 5534644Abstract: The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.Type: GrantFiled: June 5, 1995Date of Patent: July 9, 1996Assignee: Aktiebolaget AstraInventors: Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szvoboda nee Kanzel, Gergely Heja, Pal Kiss, Csaba Gonczi, Ferenc Sperber, Csaba Huszar, Gyorgy Mihalovics, Attila Nemeth, Mihaly Su, Karol Gyure, Istvan Bone, Ferenc Morasz, Laszlo Ledniczky, Erzsebet Szabo nee Kardos, Peter Gy ri, Erzsebet Szalay, Karoly Ban, Iidiko Buttkai, Arpad K vari, Sandor Garaczy
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Patent number: 5338868Abstract: A process is disclosed for the preparation of a compound of the Formula (VI) ##STR1## wherein X is a hydrogen atom, or OH,Y is a hydrogen atom, OH or a methyl group,R.sup.2 is a CH--COOR group, or a group of the formula (XI) ##STR2## and R is a C.sub.1 to C.sub.2 alkyl group, which comprises the step of: reacting a condensed salt of the Formula (IV) ##STR3## wherein Me is Na.sup.+ or K.sup.+, with a reactive derivative of trifluoromethane-sulfonic acid of the Formula (V)F.sub.3 C--SO.sub.2 OH.The compounds of the Formula (VI) are intermediates in the preparation of penicillins and cephalosporins with antibiotic activity.Type: GrantFiled: May 24, 1991Date of Patent: August 16, 1994Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara Rt.Inventors: Karoly Ban, Annamaria Ban, Lajosne Pali, Marta Kruppa, Eva Somfai, Csaba Huszar
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Patent number: 5023337Abstract: The present invention is directed to the preparation of benzimidazole derivatives of the formula (I), ##STR1## wherein A=stands for S, SO or SO.sub.2,R.sup.1 =stands for C.sub.1-4 alkyl group,R.sup.2 =stands for C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl or C.sub.6-10 aryl or aralkyl,comprising reacting a sulphochloride of the formula (II) ##STR2## with an alkyl aluminum compound of the formula (III).R.sub.n.sup.2 AlClhd (3-n) (III)The reaction is performed in one step.Type: GrantFiled: January 19, 1990Date of Patent: June 11, 1991Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Ferenc Sperber, Csaba Huszar, Attila Nemeth, Eva Somfai, Iren Pali nee Ivanics