Patents by Inventor Csaba Santa

Csaba Santa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Industrial process for the synthesis of nomegestrol-acetate
    Patent number: 11274119
    Abstract: The invention relates to the last step of a synthetic process, in which Nomegestrol-acetate of formula (I) is synthesized from 17?-acetoxy-6-methylene-19-norpregn-4-ene-3,20-dione of formula (II) in the presence of Pd/C catalyst and acetic acid in hot ethanolic solution.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: March 15, 2022
    Assignee: Richter Gedeon Nyrt.
    Inventors: Sándor Mahó, János Csörgei, Csaba Sánta, Péter Vincze, László Balogh, János Horváth, Zoltán Béni
  • INDUSTRIAL PROCESS FOR THE SYNTHESIS OF NOMEGESTROL-ACETATE
    Publication number: 20210115084
    Abstract: The invention relates to the last step of a synthetic process, in which Nomegestrol-acetate of formula (I) is synthesized from 17?-acetoxy-6-methylene-19-norpregn-4-ene-3,20-dione of formula (II) in the presence of Pd/C catalyst and acetic acid in hot ethanolic solution.
    Type: Application
    Filed: December 15, 2017
    Publication date: April 22, 2021
    Inventors: Sándor MAHÓ, János CSÖRGEI, Csaba SÁNTA, Péter VINCZE, László BALOGH, János HORVÁTH, Zoltán BÉNI
  • Process for the production of 21-methoxy-11-beta-phenyl-19-nor-pregna-4,9-diene-3,20-dione derivatives
    Patent number: 9683010
    Abstract: The present invention relates to a process for the synthesis of compounds of formula (I), wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R? is dimethylamino or 2-methyl-1,3-dioxan-2-yl group, as starting material and methoxymethyl lithium as reagent.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: June 20, 2017
    Assignee: Richter Gedeon Nyrt.
    Inventors: Sándor Mahó, Csaba Sánta, János Csörgei, Gábor Szabó, Tamás Schäfer, Zoltán Béni
  • Industrial process for the synthesis of ulipristal acetate and its 4?-acetyl analogue
    Patent number: 9676814
    Abstract: The present invention relates to a new process for the synthesis of compounds of formula (I) (wherein the meaning of R is dimethylamino or acetyl group) using the compound of formula (II) (wherein the meaning of R is dimethylamino or 2-methyl-1,3-dioxolan-2-yl group) as starting material, as well as to the intermediate of the process.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: June 13, 2017
    Assignee: RICHTER GEDEON NYRT.
    Inventors: Sándor Mahó, Csaba Sánta, János Csörgei, János Horváth, Antal Aranyi, Zoltán Béni
  • Process for the production of 19-norpregn-4-en-3,20-dione-17?-ol(gestonorone) and intermediates therefor
    Patent number: 9562067
    Abstract: The present invention relates to a new stereoselective process for the synthesis of 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one (gestonorone) is an important intermediate in the synthesis of the active ingredients having progestogen activity—such as gestonorone capronate and nomegestroi acetate. Formulas (I), (II) and (III).
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: February 7, 2017
    Assignee: RICHTER GEDEON NYRT.
    Inventors: János Csörgei, Anita Horváth, Csaba Sánta, Sándor Mahó, Zoltán Béni, János Horváth
  • PROCESS FOR THE PRODUCTION OF 21-METHOXY-11-BETA-PHENYL-19-NOR-PREGNA-4,9-DIENE-3,20-DIONE DERIVATIVES
    Publication number: 20160326211
    Abstract: The present invention relates to a process for the synthesis of compounds of formula (I), wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R? is dimethylamino or 2-methyl-1,3-dioxan-2-yl group, as starting material and methoxymethyl lithium as reagent.
    Type: Application
    Filed: February 16, 2015
    Publication date: November 10, 2016
    Inventors: Sándor MAHÓ, Csaba SÁNTA, János CSÖRGEI, Gábor SZABÓ, Tamás SCHÄFER, Zoltán BÉNI
  • Industrial Process for the Synthesis of Ulipristal Acetate and its 4'-Acetyl Analogue
    Publication number: 20160311849
    Abstract: The present invention relates to a new process for the synthesis of compounds of formula (I) (wherein the meaning of R is dimethylamino or acetyl group) using the compound of formula (II) (wherein the meaning of R is dimethylamino or 2-methyl-1,3-dioxolan-2-yl group) as starting material, as well as to the intermediate of the process.
    Type: Application
    Filed: October 1, 2014
    Publication date: October 27, 2016
    Applicant: RICHTER GEDEON NYRT.
    Inventors: Sándor MAHÓ, Csaba SÁNTA, János CSÖRGEI, János HORVÁTH, Antal ARANYI, Zoltán BÉNI
  • A PROCESS FOR THE PRODUCTION OF 19-NORPREGN-4-EN-3,20-DIONE-17ALPHA-OL(GESTONORONE) AND INTERMEDIATES THEREFOR
    Publication number: 20160297848
    Abstract: The present invention relates to a new stereoselective process for the synthesis of 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one (gestonorone) is an important intermediate in the synthesis of the active ingredients having progestogen activity—such as gestonorone capronate and nomegestroi acetate. Formulas (I), (II) and (III).
    Type: Application
    Filed: December 15, 2014
    Publication date: October 13, 2016
    Inventors: János CSÖRGEI, Anita HORVÁTH, Csaba SÁNTA, Sándor MAHÓ, Zoltán BÉNI, János HORVÁTH
  • NOVEL CRYSTAL FORM OF AN ORGANIC COMPOUND AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20160220585
    Abstract: The present invention relates to novel crystalline Form II of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124), processes for the preparation thereof and pharmaceutical composition comprising it. Form II can be crystallized from different medium such as esters of C1-C4 alcohols and carboxylic acids, ketones, cyclohexane, acetonitrile, dimethylformamide, dimethyl sulfoxide, water and any mixture thereof.
    Type: Application
    Filed: December 28, 2015
    Publication date: August 4, 2016
    Inventors: Attila Balázs, János Csörgei, Ádám Demeter, Csaba Sánta
  • Crystal form of an organic compound and process for the preparation thereof
    Patent number: 9221870
    Abstract: The present invention relates to novel crystalline Form II of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124), processes for the preparation thereof and pharmaceutical compositions comprising it. Form II can be crystallized from different medium such as esters of C1-C4 alcohols and carboxylic acids, ketones, cyclohexane, acetonitrile, dimethylformamide, dimethyl sulfoxide, water and any mixture thereof.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: December 29, 2015
    Assignee: Richter Gedeon Nyrt.
    Inventors: Attila Balázs, János Csörgei, Ádám Demeter, Csaba Sánta
  • Crystalline form of antiprogestin CDB-4124
    Patent number: 8513228
    Abstract: The present invention relates to novel crystalline Form A of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124) and methods for the preparation of it in excellent purity.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: August 20, 2013
    Assignee: Richter Gedeon Nyrt.
    Inventors: Csaba Santa, Adam Demeter, Balazs Havasi, Sandor Maho
  • NOVEL CRYSTAL FORM OF AN ORGANIC COMPOUND AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20120142655
    Abstract: The present invention relates to novel crystalline Form II of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124), processes for the preparation thereof and pharmaceutical compositions comprising it. Form II can be crystallized from different medium such as esters of C1-C4 alcohols and carboxylic acids, ketones, cyclohexane, acetonitrile, dimethylformamide, dimethyl sulfoxide, water and any mixture thereof.
    Type: Application
    Filed: August 5, 2010
    Publication date: June 7, 2012
    Inventors: Attila Balázs, János Csörgei, Ádám Demeter, Csaba Sánta
  • Industrial method for the synthesis of 17-acetoxy-11?[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
    Patent number: 8183402
    Abstract: The present invention relates to a process for the synthesis of the 17-acetoxy-11?-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I): from 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II):
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: May 22, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • NOVEL CRYSTALLINE FORM OF ANTIPROGESTIN CDB-4124
    Publication number: 20120077791
    Abstract: The present invention relates to novel crystalline Form A of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124) and methods for the preparation of it in excellent purity.
    Type: Application
    Filed: March 22, 2010
    Publication date: March 29, 2012
    Inventors: Csaba Santa, Adam Demeter, Balazs Havasi, Sandor Maho
  • INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11beta-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS
    Publication number: 20100137622
    Abstract: The present invention relates to a process for the synthesis of the known 17-acetoxy-11-?-[4-(dimethyl amino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-ethandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones.
    Type: Application
    Filed: June 19, 2008
    Publication date: June 3, 2010
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • Process for the synthesis of 17&bgr;-hydroxy-17&agr;-methyl-2-oxa-5&agr;-androstane-3-one
    Patent number: 6583298
    Abstract: The invention relates to a new process for the synthesis of 17&bgr;-hydroxy-17&agr;-methyl-2-oxa-5&agr;-androstane-3-one of formula (I).
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: June 24, 2003
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Santa, Zoltan Tuba, Sandor Maho, Janos Szeles, Katalin Ferenczi, Peter Horvath, Krisztina Lancos, Tamas Mester, Arpad Trompler
  • Process for the synthesis of a-nor-seco compounds with sterane skeleton
    Patent number: 6448413
    Abstract: The invention relates to a new process for the synthesis of 17&bgr;-hydroxy-17&agr;-methyl-1,3-seco-2-nor-5&agr;-androstane-3-acid derivatives of formula (I) wherein the meaning of Z is carboxyl or formyl group and to the new secoindoxylidene carboxylic acid derivatives of formula (II) wherein R1 and R2 independently are C1-C4 alkyl or alkoxy group, hydrogen or halogen atom—which are intermediates for preparing the compounds of formula (I). The 17&bgr;-hydroxy-17&agr;-methyl-1,3-seco-2-nor-5&agr;-androstane-3-acid derivatives of formula (I) are intermediates in the synthesis of oxandrolon (17&bgr;-hydroxy-17&agr;-methyl-2-oxa-5&agr;-androstane-3-one), which is used as anabolic in therapy.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: September 10, 2002
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Csaba Santa, Zoltan Tuba, Sandor Maho, Janos Szeles, Gabor Balogh, Janos Brlik, Ferenc Trischler, Gabriella Szilagyi, Erika Bakcsi