Patents by Inventor Csaba Szantay
Csaba Szantay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7094904Abstract: A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) ?wherein R2 is hydrogen, or a C1 to C10 alkyl or phenyl group, R3 and R4 independently of each other are a C1 to C10 alkyl or phenyl group in an aqueous solution, preferably at a pH below 3 or above 8.Type: GrantFiled: September 22, 2003Date of Patent: August 22, 2006Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Jánosné´ Kreidl née Regina Hegedus, legal representative, Laszlo Czibula, Csaba Szantay, Jenone Farkas, Ida Deutschne Juhasz, Istvan Hegedus, Eva Werkne Papp, Judit Nagyne Bagdy, Agnes Piller, Janos Kreidl, deceased
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Publication number: 20040106804Abstract: A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) 1Type: ApplicationFiled: September 22, 2003Publication date: June 3, 2004Applicant: RICHTER GEDEON VEGYESZETI GYAR RT.Inventors: Janos Kreidl, Laszlo Czibula, Csaba Szantay, Jenone Farkas, Ida Deutschne Juhasz, Istvan Hegedus, Eva Werkne Papp, Judit Nagyne Bagdy, Agnes Piller, Janosne Kreidl nee Regina Hegedus
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Patent number: 6103724Abstract: The invention relates to fused heterocyclic compounds with ring junction nitrogen atom of the formula: ##STR1## wherein Q stands for 2-indolizinyl, 2-imidazo[1,2-a]pyridinyl, 2-imidazo[1,2-a]pyrimidinyl, 6-(2,3-dihydroimidazo[2,1-b]thiazol)-yl or 6-imidazo[2,1-b]thiazolyl group; and n is an integer from 2 to 4, as well as therapeutically useful salts thereof. The invention further relates to pharmaceutical compositions containing these compounds as well as a process for the preparation of the above compounds and compositions. The compounds of formula (I) exhibit mainly antipsychotic effects so the invention relates also to a method of treatment of schizophrenia, organic mental disorders, affective disorders, anxiety and personality disorders.Type: GrantFiled: April 27, 1999Date of Patent: August 15, 2000Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Istvan Laszlovszky, Gyorgy Domany, Tibor Acs, Gyorgy Ferenczy, Csaba Szantay, Eszter Thuroczyne Kalman, Erzsebet Lapis, Ferenc Trischler, Bela Hegedus, Feranc Auth, Monika Csejtei, Egon Karpati, Bela Kiss, Judit Laszy, Margit Pellioniszne Paroczai, Adam Sarkadi, Sandor Szabo
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Patent number: 6093720Abstract: The invention relates to novel racemic and optically active trans apovincaminic acid ester derivatives of formula (I), ##STR1## wherein R means hydrogen or a group (a), wherein Z stands for C.sub.1-4 alkyl, optionally substituted aryl, aralkyl, heteroaryl or 14-eburnameninyl group; and n is an integer of 2, 3 or 4, as well as therapeutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing these compounds as well as a process for the preparation of the above compounds and compositions, and in addition, to a method of treatment. The novel compounds of Formula (I) exhibit particularly antioxidant, antiischemic as well as antiamnesic effects and are useful for inhibiting lipid peroxidation and for protection from or treatment of ischemia and amnesia as well as for treating various degenerative neurological diseases, e.g. Alzheimer's disease.Type: GrantFiled: June 9, 1998Date of Patent: July 25, 2000Assignee: Richter Gedeon Vegyeszeti GmbHInventors: Csaba Szantay, Istvan Moldvai, Andras Vedres, Maria Incze, Janos Kreidl, Laszlo Czibula, Maria Farkas Nee Kiriak, Ida Deutsch Nee Juhasz, Aniko Gere, Margit Pellionisz Nee Paroczai, Erzsebet Lapis, Andras Szekeres, Maria Zajer Nee Balazs, Adam Sarkadi, Ferenc Auth, Bela Kiss, Egon Karpati, Sandor Farkas
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Patent number: 5716986Abstract: This invention relates to new oxaindene derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same.The compounds according to the invention are characterized by the general formula (1) ##STR1## wherein R.sup.1 represents lower C.sub.1-4 alkyl, lower C.sub.1-4 alkoxy or lower C.sub.3-6 cycloalkyl,R.sup.2 stands for hydrogen, lower C.sub.1-4 alkyl or lower C.sub.3-6 cycloalkyl,R.sup.3 stands for hydrogen, lower C.sub.1-4 alkyl, lower C.sub.1-4 alkoxy or benzyloxy,X denotes hydrogen, an aliphatic C.sub.1-4 -acyl or benzoyl or naphthoyl group, optionally substituted by 1 or more nitro or C.sub.1-4 -alkoxy group(s) or a group of the formula R.sup.5 R.sup.6 N--R.sup.7 --, wherein R.sup.7 represents lower C.sub.1-4 alkylene and R.sup.5 and R.sup.6 each represent lower C.sub.1-4 alkyl, or R.sup.5 and R.sup.Type: GrantFiled: June 27, 1996Date of Patent: February 10, 1998Assignee: Egis Gyogyszergyar Rt.Inventors: Csaba Szantay, Lajos Novak, Peter Kovacs, Klara Gado, Gabor Gigler, Julianna Takacs nee Bitai, Andras Egyed, Daniel Bozsing, Gyorgy Pirok, Katalin Szemeredi, Margit Csorgo, Sandor Drabant, Gabor Blasko, Gyula Simig, Gabor Kovacs
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Patent number: 5707976Abstract: Anti-Fungal compounds are disclosed of the Formula (I) ##STR1## wherein R.sup.1 is C.sub.1 to C.sub.10 alkyl, phenyl, or phenyl-C.sub.1 to C.sub.6 alkyl, and the phenyl moiety of the two latter groups may carry at least one substituent selected from the group consisting of a halogen atom,C.sub.1 to C.sub.6 alkoxy group, phenyl group, phenoxy group, and trifluorome thyl group;R.sup.2 is a hydrogen atom, a C.sub.1 to C.sub.10 alkyl group or a phenyl group;R.sup.3 and R.sup.4 are independently from each other a C.sub.1 to C.sub.10 alkyl group or a phenyl group;X is a hydrogen atom, halogen atom or a group of the formula (A) ##STR2## and in this formula Y.sup.1 and Y.sup.2 are independently from each other, a --N.dbd. atom or a group of the formula --CH.dbd., or an optical antipode thereof.Type: GrantFiled: March 4, 1996Date of Patent: January 13, 1998Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Janos Kreidl, Csaba Szantay, Laszlo Czibula, Maria nee Kirjak Farkas, Ida nee Juhasz Deutsch, Mihaly Szegedi, Istvan Hegedus
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Patent number: 5510345Abstract: The invention relates to novel eburnamenine derivatives of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 as well as R.sup.3 and R.sup.4, independently from each other, stand for hydrogen, C.sub.2-6 alkyl group, C.sub.2-6 alkenyl group; or a C.sub.3-10 alicyclic group involving 1 to 3 rings, and this latter group may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4, together with the adjacent nitrogen atom and optionally with an additional oxygen or nitrogen atom, form a 4- to 6-membered, saturated or unsaturated cyclic group which may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; two of X, Y and Z are nitrogen whereas the third of them means a methine group; n is 1 or 2; W means oxygen or two hydrogen atoms; and the wavy line means .alpha.-/.alpha.-, .alpha.-/.beta.- or .beta.-/.alpha.- steric position, as well as their acid addition salts and solvates.Type: GrantFiled: December 8, 1994Date of Patent: April 23, 1996Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Zoltan Tuba, Sandor Maho, Aniko Gere, Pal Vittay, Bela Kiss, Eva Palosi, Laszlo Szporny, Csaba Szantay, Ferenc Soti, Zsuzsa Baloghne Kardos, Maria Incze, Gabor Balogh, Maria Gazdag
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Patent number: 5424327Abstract: The invention relates to novel combined compositions for combatting plant, animal and sanitarian as well as forestry, horticultural and warehouse pests. These compositions contain a pyrethroid-type insecticide as an insecticidally active ingredient and at least one fungicide inhibiting the ergosterol biosynthesis as activity-strengthening agent as well as optionally piperonylbutoxide and other additives.The advantages of the compositions according to the invention consist therein that the activity-strengthening substances used are fungicidal agents widely used and have an advantageous toxicology. The activity-strengthening agent exerts a synergistic effect together with the pyrethroid-type insecticide.The combinations according to the invention bear an outstanding importance in the protection of stored crops.Type: GrantFiled: September 9, 1994Date of Patent: June 13, 1995Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Laszlo Pap, Istvan Szekely, Lajos Nagy, Andras Szego, Andrea Toth, Eva Somfai, Csaba Szantay, Lajos Novak, Laszlo Poppe
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Patent number: 5389662Abstract: The invention relates to novel combined compositions for combatting plant, animal and sanitarian as well as forestry, horticultural and warehouse pests. These compositions contain a pyrethroid-type insecticide as an insecticidally active ingredient and at least one fungicide inhibiting the ergosterol biosynthesis as activity-strengthening agent as well as optionally piperonylbutoxide and other additives.The advantages of the compositions according to the invention consist therein that the activity-strengthening substances used are fungicidal agents widely used and have an advantageous toxicology. The activity-strengthening agent exerts a synergistic effect together with the pyrethroid-type insecticide.The combinations according to the invention bear an outstanding importance in the protection of stored crops.Type: GrantFiled: May 31, 1991Date of Patent: February 14, 1995Assignee: Chinoin Gyogyszer Es Vegyeszeti Termekek Gyar Rt.Inventors: Laszlo Pap, Istvan Szekely, Lajos Nagy, Andras Szego, Andrea Toth, Eva Somfai, Csaba Szantay, Lajos Novak, Laszlo Poppe
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Patent number: 5122607Abstract: New intermediate compounds are disclosed of the formula I, ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl having 1 to 4 carbon atoms,or acid-addition salts thereof of formula Ib, ##STR2## wherein X represents an acid residue, and a process for the preparation of the intermediate compounds.Type: GrantFiled: June 21, 1990Date of Patent: June 16, 1992Assignee: Richter Gedeon Vegyesczeti Gyar RT.Inventors: Janos Kreidl, Csaba Szantay, Lajos Szaho, Maria Farkas nee Kirjak, Gyorgy Kalaus, Katalin Nogradi, Andras Nemes, Judit Meszaros nee Brill, Zsuzsanna Aracs nee Tischler, Bela Stefko, Janos Sapi, Ida Deutsch nee Juhasz, Istvan Hegedus, Bela Benke, Kalman Graf, Kalmam Gaf, Katalin Horvath nee Berki
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Patent number: 4960888Abstract: The invention relates to a new process for preparing 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine of the formula (I), ##STR1## which comprises reacting a pyrimidine derivative of the general formula (II), ##STR2## wherein R.sub.1 stantds for hydrogen or a ##STR3## group, wherein R means a C.sub.1-6 alkyl group or an aryl group optionally substituted by halogen;R.sub.2 stands for a hydroxyl group or an ##STR4## group, wherein R is as defined above; andX represents chlorine or bromine or an optionally mono- or polysubstituted arenesulfonyloxy group,with the proviso that R.sub.2 is different from a hydroxyl group when R.sub.1 stands for hydrogen, with piperidine and hydrolyzing, optionally after isolation, the thus-obtained 4-piperidino derivative of the general formula (III), ##STR5## wherein R.sub.1 and R.sub.2 are as defined above.Type: GrantFiled: March 9, 1989Date of Patent: October 2, 1990Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Andras Vedres, Csaba Szantay, Bela Stefko, Janos Kreidl, Andras Nemes, Gabor Blasko, Erik Bogsch, Denes Mathe, Istvan Hegedus, Adrien Szuchovszky, nee Gergely, Tamas Mester
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Patent number: 4843080Abstract: The invention relates to new racemic and optically active 1,12b-disubstituted octahydroindolo[2,3-a]quinolizine derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent hydrogen, halogen, nitro, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms or hydroxyl,R.sup.3 and R.sup.5 are the same or different and represent hydrogen, alkyl having from 1 to 6 carbon atoms or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety,R.sup.4 is alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety, andR.sup.6 is an electron attracting substitutent, and cis and trans isomers and acid addition salts thereof.The compounds are pharmaceutically active, in particular show an outstanding cardiovascular, e.g. selective peripheral vasodilating activity. Some of these compounds are valuable intermediates in the preparation of other, pharmaceutically active compounds.Type: GrantFiled: April 17, 1986Date of Patent: June 27, 1989Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Csaba Szantay, Ferenc Soti, Maria Incze, Zsuzsanna Balogh nee Kardos, Zsolt Szombathelyi, Egon Karpati, Bela Kiss, Katalin Csomor, Istvan Laszlovszky, Erzsebet Lapis, Lilla Forgacs, Csaba Kuthi, Laszlo Szporny
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Patent number: 4810709Abstract: The invention relates to a new process for preparing novel racemic and optically active 9- or 11-nitroapovincaminic acid derivatives of the general formula (I) ##STR1## wherein R stands for a --CO--X group, wherein X means a halogen atom; orfor a --CO--OR.sup.1 group, wherein R.sup.1 means an optionally mono- or polysubstituted C.sub.1-10 aliphatic group, a C.sub.3-8 alicyclic group or an aromatic C.sub.6-14 hydrocarbyl group; orfor a --CO--NR.sup.2 R.sup.3 group, wherein R.sup.2 and R.sup.3 are the same or different and stand for a hydrogen atom or a C.sub.1-8 alkyl group optionally forming a saturated heterocycle together with the adjacent nitrogen atom and optionally with one or more further nitrogen atoms or other heteroatoms, and R.sup.3 may also represent an amino group when R.sup.2 stands for a hydrogen atom; orfor a cyano group,as well as their salts and pharmaceutical preparations containing these compounds.Type: GrantFiled: October 7, 1987Date of Patent: March 7, 1989Assignee: Richter Gedeon Vegyeszefi Gyar R.T.Inventors: Andras Vedres, Csaba Szantay, Istvan Moldvai, Bela Stefko, Dora Groo, Egon Karpati, Bela Kiss, Eva Palosi, Miklos Riesz, Zsolt Szombathelyi, Laszlo Szporny, Maria Zajer nee Balazs
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Patent number: 4806545Abstract: The invention relates to the new (-)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2, 3,4,6,7,12,12b.alpha.-octa-hydroindolo[2,3-a] quinolizine of the formula (I) ##STR1## and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydrolysis and/or salt formation.The compound of formula (I) shows a remarkable peripheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.Type: GrantFiled: April 14, 1986Date of Patent: February 21, 1989Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Zsolt Szombathelyi, Egon Karpati, Bela Kiss, Katalin Csomor, Istvan Laszlovszky, Erzsebet Lapis, Laszlo Szporny, Lilla Forgacs, Csaba Kuthi, Aniko Gere
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Patent number: 4782052Abstract: The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3,-a]quinolizin-1-yl-alkanecarboxylic acid amides of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 stand independently for a hydrogen or halogen atom, or a hydroxyl, nitro or C.sub.1-4 alkoxy group;R.sub.3 and R.sub.4 stand independently for a hydrogen atom or a C.sub.1-4 alkyl group;R.sub.5 and R.sub.6 stand independently for a hydrogen atom, C.sub.1-8 alkyl group, C.sub.3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl group containing oxygen, nitrogen or sulphur atom, all these groups being optionally substituted; orR.sub.5 and R.sub.6 together form an optionally substituted C.sub.2-8 .alpha.,.omega.-alkylene group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; andG means a C.sub.1-4 straight chained alkylene group, as well as to their therapeutically suitable acid addition salts and pharmaceutical compositions containing these compounds.Type: GrantFiled: October 3, 1985Date of Patent: November 1, 1988Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Ferenc Soti, Csaba Szantay, Maria Incze, Zsuzsanna Balogh nee Kardos, Elemer Ezer, Judit Matuz, Laszlo Szporny, Gyorgy Hajos, Csaba Kuthi
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Patent number: 4780537Abstract: A pyrimidine derivative of the formulae (Ia), (Ib) and (Ic), ##STR1## wherein R stands for an alkyl group group with 1 to 6 carbon atoms or an aryl group optionally substituted by halogen atom; andX stands for chlorine or bromine atom or an arylsulfonyloxy group optionally substituted by 1 to 3 lower alkyl groups.The subject pyrimidine derivatives are intermediates for preparing 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine.Type: GrantFiled: July 10, 1987Date of Patent: October 25, 1988Assignee: Richter Gedeon Vegyeszeti Gyar R. T.Inventors: Andras Vedres, Csaba Szantay, Bela Stefko, Janos Kreidl, Andras Nemes, Gabor Blasko, Erik Bogsch, Denes Mathe, Istvan Hegedus, Adrien Szuchovszky nee Gergely, Tamas Mester
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Patent number: 4757077Abstract: The invention relates to novel bis-indole derivatives of the general formula (I) ##STR1## wherein R.sub.1 stands for a hydrogen atom or an acetyl group;R.sub.2 stands for a hydrogen atom;R.sub.3 means an ethyl group of .alpha.-position; orR.sub.2 and R.sub.3 together represent an oxygen bridge;R.sub.4 represents an ethyl or hydroxyl group of .beta.-position; andR.sub.5 stands for a hydrogen atom or a hydroxyl group;A represents a C.sub.1-10 straight-chain or C.sub.3-10 branched-chain alkyl group, hydroxy-alkyl, acetyl-alkyl, benzyl, C.sub.3-6 alkenyl or alkynyl or C.sub.5-7 cycloalkyl group or an aromatic group or a heteroaromatic group containing one nitrogen or one oxygen atom, andX stands for oxygen or sulphur atom,as well as their acid addition salts and pharmaceutical preparations containing these compounds.Further on, the invention relates to a process for preparing these compounds and preparations.Type: GrantFiled: June 12, 1986Date of Patent: July 12, 1988Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Csaba Szantay, Lajos Szabo, Katalin Honty, Tibor Keve, Tibor Acs, Sandor Eckhardt, Janos Sugar, Zsuzsa Somfai, Eva Ivan, Zsuzsa Kneffel
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Patent number: 4753948Abstract: The invention relates to novel furfuryl derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for a hydrogen atom or an acetyl group,R.sub.2 stands for a hydroxyl or ethyl group of.beta.-position;R.sub.3 means an ethyl group of .alpha.-position;R.sub.4 represents a hydrogen atom; orR.sub.3 and R.sub.4 together represent an oxygen bridge; andB stands for a hydroxyl of an O-acyl group, as well as their acid addition salts and pharmaceutical preparations containing these compounds. Further on, the invention relates to a process for preparing these compounds and preparations.The compounds of the general formula (I) show a cytostatic activity with less toxicity than that of the commerically available known vinblastine-type bis-indole alkaloid drugs.Type: GrantFiled: June 12, 1986Date of Patent: June 28, 1988Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Csaba Szantay, Lajos Szabo, Katalin Honty, Tibor Keve, Tibor Acs, Sandor Eckhardt, Janos Sugar, Zsuzsa Somjai, Eva Ivan, Zsuzsa Kneffel
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Patent number: 4746665Abstract: The invention relates to novel nitro derivatives of the general formula (I) ##STR1## wherein R.sub.1 stands for a methyl or a formyl group;R.sub.2 stands for a hydroxy or ethyl group of .beta.-position;R.sub.3 means an ethyl group of .alpha.-position;R.sub.4 represents a hydrogen atom; orR.sub.3 and R.sub.4 together represent an oxygen bridge or a double bond;R.sub.5, R.sub.6 and R.sub.7 stand for a nitro group or hydrogen atom, with the proviso that simultaneously only one of them may stand for hydrogen atom; andY stands for --N.dbd. when R.sub.5 stands for a nitro group; whereasY stands for --NH-- when R.sub.5 stands for a hydrogen atom and a valence bond exists between the C.sub.2, and C.sub.7, atoms,as well as their acid addition salts and pharmaceutical preparations containing these compounds.Further on, the invention relates to a process for preparing these compounds and preparations.Type: GrantFiled: June 12, 1986Date of Patent: May 24, 1988Assignee: Richter Gedeon Vegyeszeti GyarInventors: Csaba Szantay, Lajos Szabo, Katalin Honty, Tibor Keve, Tibor cs, Sandor Eckhardt, Janos Sugar, Zsuzsa Somfai, Eva Ivan, Zsuzsa Kneffel
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Patent number: 4735946Abstract: The invention relates to new eburnane derivatives of the formula (I) ##STR1## wherein R.sup.1 is alkyl having from 1 to 6 carbon atoms, and acid addition salts thereof.The invention further relates to a process for the preparation of these compounds and pharmaceutical compositions containing them.Compounds of formula (I) show remarkable CNS-activity and are useful intermediates in the preparation of other, pharmaceutically active compounds.Type: GrantFiled: April 2, 1985Date of Patent: April 5, 1988Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Janos Kreidl, Maria Farkas nee Kirjak, Laszlo Czibula, Bela Stefko, Gyorgy Visky, Judit Meszaros nee Brill