Patents by Inventor Csaba Varadi
Csaba Varadi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11958798Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.Type: GrantFiled: October 25, 2022Date of Patent: April 16, 2024Assignee: EUROAPI HUNGARY LIMITED LIABILITY COMPANYInventors: Imre Rozsumberszki, Zsuzsanna Kardos, Irén Hortobágyi, Tibor Szabó, Csaba Váradi, Tamás Bán
-
Publication number: 20230194537Abstract: The invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. The invention relates, in part, to glycan labeling with formulas/compounds enhancing their detection and/or analysis by methods such as capillary electrophoresis, liquid chromatography and mass spectrometry. These detection methods may be useful in studying glycosylation patterns of biological or medical samples, or for assessing protein production, protein quality/purity, for comparing innovator and biosimilar glycosylated proteins, or for selecting proteins with the desired glycosylation.Type: ApplicationFiled: March 16, 2018Publication date: June 22, 2023Inventors: Shaheer H. KHAN, Jonathan BONES, Csaba VARADI
-
Publication number: 20230115500Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.Type: ApplicationFiled: October 25, 2022Publication date: April 13, 2023Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre ROZSUMBERSZKI, Zsuzsanna KARDOS, Irén HORTOBÁGYI, Tibor SZABÓ, Csaba VÁRADI, Tamás BÁN
-
Patent number: 11535580Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.Type: GrantFiled: April 16, 2019Date of Patent: December 27, 2022Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre Rozsumberszki, Zsuzsanna Kardos, Irén Hortobágyi, Tibor Szabó, Csaba Váradi, Tamás Bán
-
Publication number: 20220163549Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method using magnetic beads containing negatively charged carboxyl groups extending from the surface of the magnetic beads.Type: ApplicationFiled: February 14, 2022Publication date: May 26, 2022Inventors: Andras Guttman, Clarence Lew, Marton Szigeti, Csaba Varadi
-
Patent number: 11249098Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method using magnetic beads containing negatively charged carboxyl groups extending from the surface of the magnetic beads.Type: GrantFiled: February 15, 2019Date of Patent: February 15, 2022Assignee: Beckman Coulter, Inc.Inventors: Andras Guttman, Clarence Lew, Marton Szigeti, Csaba Varadi
-
Publication number: 20210147329Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.Type: ApplicationFiled: April 16, 2019Publication date: May 20, 2021Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre ROZSUMBERSZKI, Zsuzsanna KARDOS, Irén HORTOBÁGYI, Tibor SZABÓ, Csaba VÁRADI, Tamás BÁN
-
Patent number: 10442762Abstract: The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silica gel chromatography and the salt formation is carried out by using solid tromethamine base.Type: GrantFiled: November 10, 2016Date of Patent: October 15, 2019Assignee: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA ZRT.Inventors: Péter Buzder-Lantos, Zsuzsanna Kardos, Irén Hortobágyi, István Lászlófi, Imre Juhász, László Fónagy, Csaba Váradi, Ágnes Nagyné Borkó
-
Publication number: 20190227086Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol that can enable full automation and reduced sample preparation time relative to current methods of glycoanalysis. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method without requiring time-consuming sample preparation steps such as centrifugation or vacuum-centrifugation.Type: ApplicationFiled: February 15, 2019Publication date: July 25, 2019Inventors: Andras Guttman, Clarence Lew, Marton Szigeti, Csaba Varadi
-
Patent number: 10247745Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol that can enable full automation and reduced sample preparation time relative to current methods of glycoanalysis. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method without requiring time-consuming sample preparation steps such as centrifugation or vacuum-centrifugation.Type: GrantFiled: April 27, 2015Date of Patent: April 2, 2019Assignee: Beckman Coulter, Inc.Inventors: Andras Guttman, Clarence Lew, Marton Szigeti, Csaba Varadi
-
Publication number: 20180362457Abstract: The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silicagel chromatography and the salt formation is carried out by using solid tromethamine base.Type: ApplicationFiled: November 10, 2016Publication date: December 20, 2018Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT .Inventors: Péter BUZDER-LANTOS, Zsuzsanna KARDOS, Irén HORTOBÁGYI, István LÁSZLÓFI, Imre JUHÁSZ, László FÓNAGY, Csaba VÁRADI, Ágnes NAGYNÉ BORKÓ
-
Publication number: 20170045538Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol that can enable full automation and reduced sample preparation time relative to current methods of glycoanalysis. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method without requiring time-consuming sample preparation steps such as centrifugation or vacuum-centrifugation.Type: ApplicationFiled: April 27, 2015Publication date: February 16, 2017Inventors: Andras Guttman, Clarence Lew, Marton Szigeti, Csaba Varadi