Abstract: Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or C1-C6 alkyl; ring A is cyclohexyl or phenyl, optionally substituted; ring B is aryl or a nitrogen-containing heteroaryl, optionally substituted; ring C is phenyl substituted with hydroxyl; each L1, L2 and L3 is independently C1-C6 alkyl, —CONR2— or —CONR2—X—C1-C6 alkyl-, each optionally substituted; R2 is hydrogen or C1-C6 alkyl; and X is a bond or a 5-6 membered heterocycle containing up to 3 ring heteroatoms; and methods of use such as a method for increasing hematopoiesis, for enhancing expansion of a hematopoietic stem cell (HSC), or for inhibiting an interaction between a ?-, and/or ?-catenin protein in a cell or a subject by administering a compound of Formula (I) to the subject.