Abstract: Disclosed in the present disclosure is genetically modified mice in which immunoglobulin loci are modified to insert gene segments of a human immunoglobulin variable region. The mice can be bred normally and produce human-mouse chimeric antibodies including a human variable region and a mouse constant region. The present disclosure also provides a method for preparing the genetically modified mice and use of the mice.

Abstract: Disclosed in the present disclosure is genetically modified mice in which immunoglobulin loci are modified to insert gene segments of a human immunoglobulin variable region. The mice can be bred normally and produce human-mouse chimeric antibodies including a human variable region and a mouse constant region. The present disclosure also provides a method for preparing the genetically modified mice and use of the mice.

Abstract: Disclosed is a genetically modified mouse having an immunoglobulin heavy chain locus engineered to insert a gene segment of a human immunoglobulin heavy chain variable region. The mouse is able to reproduce normally and produce a human-mouse chimeric antibody comprising a human heavy chain variable region and a mouse constant region. Also provided is a method for preparing the genetically modified mouse and use of the mouse.

Abstract: A computer implemented method, computer system and computer program product are provided for lost detection for paired mobile devices. According to the method, a processor receives behavior data of paired mobile devices from one or more sensors of the paired mobile devices, wherein the behavior data comprising one or more parameters that reflect current status of the paired mobile devices. And the processor compares the received behavior data with human behavior data model. And, in response to the received behavior data being not matched with the human behavior data model, the processor determines that at least one of the paired mobile devices is lost.

Abstract: A computer implemented method, computer system and computer program product are provided for lost detection for paired mobile devices. According to the method, a processor receives behavior data of paired mobile devices from one or more sensors of the paired mobile devices, wherein the behavior data comprising one or more parameters that reflect current status of the paired mobile devices. And the processor compares the received behavior data with human behavior data model. And, in response to the received behavior data being not matched with the human behavior data model, the processor determines that at least one of the paired mobile devices is lost.