Abstract: The present disclosure discloses a horizontal well cuttings bed processing method and device. The method includes: based on drilling engineering information of a horizontal well, predicting a distribution pattern of a cuttings bed throughout a drilling process, determining a cuttings bed height risk level in each well section, and outputting a cuttings bed removal solution associated with the well section. According to the present disclosure, processing accuracy and processing efficiency of the cuttings bed in a horizontal well can be improved, and accumulation of the cuttings bed in the horizontal well can be effectively resolved.

Abstract: Provided herein are nucleic acid molecules encoding a SARS-CoV-2 S ectodomain—HBsAg fusion protein. When expressed in mammalian cells (for example, by administration to a mammalian subject), the fusion protein self-assembles to form a HBsAg protein nanoparticle with SARS-CoV-2 S ectodomain trimers extending radially outward from an outer surface of the HBsAg protein nanoparticle. Thus, in several aspects, the disclosed nucleic acid molecule can be used to generate an immune response to SARS-CoV-2 in a subject.