Patents by Inventor Cun-Jian Dong

Cun-Jian Dong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of Spasticity with Intrathecal Dantrolene
    Publication number: 20150157568
    Abstract: The present invention is directed to a method of treating spasticity in a human subject, comprising administering intrathecally to the subject a therapeutically effective amount of dantrolene or a pharmaceutically acceptable salt thereof. The administration can be through a chronical drug delivery device such as an intrathecal pump.
    Type: Application
    Filed: December 4, 2014
    Publication date: June 11, 2015
    Inventor: Cun-Jian Dong
  • Methods of Using Ryanodine Antagonists in Treating Neural Injury
    Publication number: 20140039019
    Abstract: The present invention provides a method of providing neuroprotection to a mammal comprising administering to said mammal suffering from or at risk of suffering a noxious action on its nerve cells an effective amount of a ryanodine antagonist, e.g. dantrolene, to inhibit or prevent nerve cell injury or death.
    Type: Application
    Filed: October 7, 2013
    Publication date: February 6, 2014
    Applicant: ALLERGAN, INC.
    Inventors: Cun-Jian Dong, William A. Hare
  • Methods of using ryanodine antagonists in treating neural injury
    Patent number: 8557855
    Abstract: The present invention provides a method of providing neuroprotection to a mammal comprising administering to said mammal suffering from or at risk of suffering a noxious action on its nerve cells an effective amount of a ryanodine antagonist, e.g. dantrolene, to inhibit or prevent nerve cell injury or death.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: October 15, 2013
    Assignee: Allergan, Inc.
    Inventors: Cun-Jian Dong, William A. Hare
  • Methods of determining activity of ryanodine receptor modulators
    Publication number: 20070196856
    Abstract: Methods for identifying modulators of ryanodine receptors are disclosed. In preferred embodiments the activity of the ryanodine receptor is stimulated to a baseline level and the ability of a test compound to increase or decrease the baseline level indicates that the test compound is a modulator of ryanodine receptor activity.
    Type: Application
    Filed: February 23, 2006
    Publication date: August 23, 2007
    Applicant: Allergan, Inc.
    Inventors: Cun-Jian Dong, William Hare
  • RYANODINE RECEPTOR BLOCKERS FOR TREATING PAIN
    Publication number: 20070066638
    Abstract: The present invention provides a method of preventing or ameliorating pain in a mammal comprising administering to said mammal suffering from or at risk of suffering a noxious action causing said pain, an effective amount of a ryanodine antagonist, such as dantrolene, to inhibit or prevent pain.
    Type: Application
    Filed: September 11, 2006
    Publication date: March 22, 2007
    Inventors: Cun-Jian Dong, William Hare, John Donello
  • Method of using ryanodine receptor antagonists to treat amyotrophic lateral sclerosis
    Publication number: 20070049630
    Abstract: The present invention provides a method of providing neural protection in in human patients suffering from amyotrophic lateral sclerosis comprising administering to said patients suffering from said amyotrophic lateral sclerosis an effective amount of a compound that is a ryanodine receptor antagonist in pharmaceutically acceptable vehicle to inhibit or prevent neuronal njury or death.
    Type: Application
    Filed: June 7, 2006
    Publication date: March 1, 2007
    Inventors: Cun-Jian Dong, William Hare
  • Methods of using ryanodine antagonists in treating neural injury
    Publication number: 20060030548
    Abstract: The present invention provides a method of providing neuroprotection to a mammal comprising administering to said mammal suffering from or at risk of suffering a noxious action on its nerve cells an effective amount of a ryanodine antagonist, e.g. dantrolene, to inhibit or prevent nerve cell injury or death.
    Type: Application
    Filed: September 29, 2005
    Publication date: February 9, 2006
    Inventors: Cun-Jian Dong, William Hare
  • Calcium blockers to treat proliferative retinal diseases
    Publication number: 20050009884
    Abstract: Glutamate causes migration and proliferation of retinal pigment epithelium and/or glial cells, and glutamate antagonists can prevent, treat or reduce retinal pigment epithelium and/or glial migration and the subsequent development of proliferative vitreoretinopathy. Avoidance or management of proliferative vitreoretinopathy can be achieved by administering to the patient a compound capable of reducing glutamate-induced retinal cell migration in a concentration effective to reduce such migration.
    Type: Application
    Filed: December 12, 2003
    Publication date: January 13, 2005
    Inventors: Evan Dreyer, Scott Whitcup, William Hare, Cun Jian Dong
  • Methods of using ryanodine antagonists in treating neural injury
    Publication number: 20040006124
    Abstract: The present invention provides a method of providing neuroprotection to a mammal comprising administering to said mammal suffering from or at risk of suffering a noxious action on its nerve cells an effective amount of a ryanodine antagonist, e.g. dantrolene, to inhibit or prevent nerve cell injury or death.
    Type: Application
    Filed: July 3, 2002
    Publication date: January 8, 2004
    Applicant: Allergan, Inc.
    Inventors: Cun-Jian Dong, William A. Hare