Abstract: The present application discloses two anti-GDF15 neutralizing monoclonal antibodies and uses thereof. The variable regions of the light chain and heavy chain of the antibodies G1 and G2 with neutralizing activity are provided. Anti-GDF15 mouse monoclonal antibodies were prepared by the hybridoma technology, anti-GDF15 hybridoma cell lines capable of stable secretion with high specificity were screened out, ascites were prepared to obtain high-specificity and high-affinity anti-GDF15 monoclonal antibodies and two anti-GDF15 monoclonal antibodies with neutralizing activity were identified for the first time by constructing an antibody neutralization detection system.

Abstract: A toothbrush is provided that includes a base component having a gripping region and an oral engaging region defining a longitudinal axis along a length of the oral engaging region and a transverse axis along a width of the oral engaging region. The oral engaging region has bilateral symmetry with respect to the longitudinal axis and can comprise wherein the oral engaging region has bilateral symmetry with respect to the longitudinal axis and comprises a first distal region having an approximately concave contour tapering to a second middle region having an approximately convex contour and widening to a third proximal region having an approximately concave contour. The oral engaging region can support a plurality of cleaning elements along a front side and a plurality of soft cleaning elements along a second side opposite the first.

Abstract: A photocatalytic honeycomb assembly and a photocatalytic purification apparatus, which can maximally increase a contact area between polluted air and a photocatalyst while maximally ensuring that the surface of the photocatalyst receives sufficient irradiation of ultraviolet light, and can also make the flow resistance to air flowing in a channel meet requirements in the field of ventilation systems which have high requirements on flow resistance. The photocatalytic honeycomb assembly is formed of one or more photocatalytic honeycomb cores and a photocatalytic honeycomb assembly housing. The one or more photocatalytic honeycomb cores are arranged in a honeycomb form. The photocatalytic honeycomb core is formed of three or more basic core units and a light guide member that is Y-shaped in an end view.

Abstract: A photocatalytic honeycomb assembly and a photocatalytic purification apparatus, which can maximally increase a contact area between polluted air and a photocatalyst while maximally ensuring that the surface of the photocatalyst receives sufficient irradiation of ultraviolet light, and can also make the flow resistance to air flowing in a channel meet requirements in the field of ventilation systems which have high requirements on flow resistance. The photocatalytic honeycomb assembly is formed of one or more photocatalytic honeycomb cores and a photocatalytic honeycomb assembly housing. The one or more photocatalytic honeycomb cores are arranged in a honeycomb form. The photocatalytic honeycomb core is formed of three or more basic core units and a light guide member that is Y-shaped in an end view.

Abstract: A toothbrush is provided that includes a base component having a gripping region and an oral engaging region defining a longitudinal axis along a length of the oral engaging region and a transverse axis along a width of the oral engaging region. The oral engaging region has bilateral symmetry with respect to the longitudinal axis and can comprise wherein the oral engaging region has bilateral symmetry with respect to the longitudinal axis and comprises a first distal region having an approximately concave contour tapering to a second middle region having an approximately convex contour and widening to a third proximal region having an approximately concave contour. The oral engaging region can support a plurality of cleaning elements along a front side and a plurality of soft cleaning elements along a second side opposite the first.