Patents by Inventor Cun-Yu Wang

Cun-Yu Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY
    Publication number: 20240059654
    Abstract: The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.
    Type: Application
    Filed: March 24, 2023
    Publication date: February 22, 2024
    Inventors: Michael E. Jung, Xiaohong Chen, Cun-Yu Wang, Jiong Li, Jie Zheng
  • INHIBITION OF BMI1 ELIMINATES CANCER STEM CELLS AND ACTIVATES ANTITUMOR IMMUNITY
    Publication number: 20230233566
    Abstract: The present disclosure reports that pharmacological or genetic inhibition of Moloney murine leukemia virus insertion site 1 (BMI1) not only helped to eliminate BMI1+ cancer stem cells (CSCs), but can also augment PD1 blockade by strongly induced tumor cell-intrinsic immune responses by recruiting and activating CD8+ T cells. Taken together, the results indicate that in addition to purging CSCs, targeting BMI1 would enable immune checkpoint blockade to inhibit metastatic tumor growth and prevent tumor relapse by activating cell-intrinsic immunity.
    Type: Application
    Filed: June 3, 2021
    Publication date: July 27, 2023
    Applicant: The Regents of the University of California
    Inventors: Cun-Yu WANG, Lingfei JIA
  • Inhibitors of the WNT/beta-catenin pathway
    Patent number: 11708329
    Abstract: The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: July 25, 2023
    Assignee: The Regents of the University of California
    Inventors: Michael E. Jung, Xiaohong Chen, Cun-Yu Wang, Jiong Li, Jie Zheng
  • INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY
    Publication number: 20210371384
    Abstract: The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.
    Type: Application
    Filed: January 30, 2019
    Publication date: December 2, 2021
    Inventors: Michael E. Jung, Xiaohong Chen, Cun-Yu Wang, Jiong Li, Jie Zheng
  • COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING A BONE CONDITION
    Publication number: 20160346350
    Abstract: The present invention discloses a composition for bone regeneration in a subject and method of using and making the same.
    Type: Application
    Filed: January 29, 2015
    Publication date: December 1, 2016
    Inventors: Cun-yu Wang, Bo Yu, Jia Chang
  • Use NF-B inhibition in combination therapy for cancer
    Patent number: 7700543
    Abstract: The use of NF-?B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described. When chemotherapeutic compounds and radiation activate NF-?B within cells, the cells are more resistant to the cytotoxic effects of these treatments. Inhibition of NF-?B activation is disclosed to provide a method to improve the efficacy of these cancer therapies.
    Type: Grant
    Filed: November 2, 2004
    Date of Patent: April 20, 2010
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Albert S. Baldwin, James C. Cusack, Marty W. Mayo, Cun-Yu Wang
  • Use of NF-?B inhibition in combination therapy for cancer
    Patent number: 7700073
    Abstract: The use of NF-?B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: April 20, 2010
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Albert S. Baldwin, James C. Cusack, Marty W. Mayo, Cun-Yu Wang
  • Use of NF-B inhibition in combination therapy for cancer
    Patent number: 7700545
    Abstract: The use of NF-?B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: April 20, 2010
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Albert S. Baldwin, James C. Cusack, Marty W. Mayo, Cun-Yu Wang
  • Use of NF-kB Inhibition in Combination Therapy for Cancer
    Publication number: 20070110828
    Abstract: The use of NF-?B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described.
    Type: Application
    Filed: September 27, 2006
    Publication date: May 17, 2007
    Inventors: Albert Baldwin, James Cusack, Marty Mayo, Cun-Yu Wang
  • Use of NF-kB Inhibition in Combination Therapy for Cancer
    Publication number: 20070105751
    Abstract: The use of NF-?B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described.
    Type: Application
    Filed: September 27, 2006
    Publication date: May 10, 2007
    Inventors: Albert Baldwin, James Cusack, Marty Mayo, Cun-Yu Wang
  • Use of NF-kB inhibition in combination therapy for cancer
    Publication number: 20050123506
    Abstract: The use of NF-?B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described.
    Type: Application
    Filed: November 2, 2004
    Publication date: June 9, 2005
    Inventors: Albert Baldwin, James Cusack, Marty Mayo, Cun-Yu Wang
  • Use of NF-&kgr;B inhibition in combination therapy for cancer
    Patent number: 6831057
    Abstract: The use of NF-&kgr;B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: December 14, 2004
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Albert S. Baldwin, James C. Cusack, Marty W. Mayo, Cun-Yu Wang
  • USE OF NF-KB INHIBITION IN COMBINATION THERAPY FOR CANCER
    Publication number: 20020068690
    Abstract: The use of NF-&kgr;B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described.
    Type: Application
    Filed: October 28, 1997
    Publication date: June 6, 2002
    Inventors: ALBERT S. BALDWIN, JAMES C. CUSACK, MARTY W. MAYO, CUN-YU WANG