Patents by Inventor Cuong Ly
Cuong Ly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8163763Abstract: Disclosed are compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).Type: GrantFiled: July 31, 2009Date of Patent: April 24, 2012Assignee: Genentech, Inc.Inventors: Philippe Bergeron, Frederick Cohen, Anthony Estrada, Michael F. T. Koehler, Kevin Hon Luen Lau, Cuong Ly, Joseph P. Lyssikatos, Daniel Ortwine, Zhonghua Pei, Xianrui Zhao
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Publication number: 20100331305Abstract: Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).Type: ApplicationFiled: June 23, 2010Publication date: December 30, 2010Applicant: Genentech, Inc.Inventors: Philippe Bergeron, Frederick Cohen, Anthony Estrada, Michael F.T. Koehler, Cuong Ly, Joseph P. Lyssikatos, Zhonghua Pei, Wendy Lee, Xianrui Zhao
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Publication number: 20100069357Abstract: Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).Type: ApplicationFiled: July 31, 2009Publication date: March 18, 2010Applicant: Genentech, Inc.Inventors: Philippe Bergeron, Frederick Cohen, Anthony Estrada, Michael F.T. Koehler, Kevin Hon Luen Lau, Cuong Ly, Joseph P. Lyssikatos, Daniel Ortwine, Zhonghua Pei, Xianrui Zhao
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Publication number: 20090318409Abstract: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4?, R5, R6 and R6? are as described herein.Type: ApplicationFiled: August 10, 2009Publication date: December 24, 2009Applicant: Genentech, Inc.Inventors: Frederick Cohen, Vickie Hsiao-Wei Tsui, Cuong Ly, John A. Flygare
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Publication number: 20090176822Abstract: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4?, R5, R6 and R6? are as described herein.Type: ApplicationFiled: April 17, 2008Publication date: July 9, 2009Applicant: Genentech, Inc.Inventors: Frederick Cohen, Vickie Hsiao-Wei Tsui, Cuong Ly, John A. Flygare
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Publication number: 20060167066Abstract: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4?, R5, R6? and R6? are as described herein.Type: ApplicationFiled: December 19, 2005Publication date: July 27, 2006Applicant: Genentech, Inc.Inventors: Frederick Cohen, Vickie Tsui, Cuong Ly, John Flygare
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Patent number: 6890707Abstract: A print material having a support, at least one red-sensitive silver halide emulsion layer containing at least one cyan coupler, at least one green-sensitive silver halide emulsion layer containing at least one magenta coupler and at least one blue-sensitive silver halide emulsion layer containing at least one yellow coupler, characterised in that the silver halide crystals of the red-sensitive layer have a chloride content of at least 95 mol %, contain 20 to 500 nmol of iridium per mol of silver halide and the cyan coupler is of the formula in which R1 means a hydrogen atom or an alkyl group, R2 means an alkyl, aryl or hetaryl group, R3 means an alkyl or aryl group, R4 means an alkyl, alkenyl, alkoxy, aryloxy, acyloxy, acylamino, sulfonyloxy, sulfamoylamino, sulfonamido, ureido, hydroxycarbonyl, hydroxycarbonylamino, carbamoyl, alkylthio, arylthio, alkylamino or arylamino group or a hydrogen atom and Z means a hydrogen atom or a group eliminable under the conditions of chromogenic development, is disType: GrantFiled: July 2, 2003Date of Patent: May 10, 2005Assignee: Agfa-GevaertInventors: Ralf Weimann, Markus Geiger, Cuong Ly, Klaus Sinzger, Beate Weber, Heinz Wiesen
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Patent number: 6806042Abstract: A print material having a support, at least one red-sensitive silver halide emulsion layer containing at least one cyan coupler, at least one green-sensitive silver halide emulsion layer containing at least one magenta coupler and at least one blue-sensitive silver halide emulsion layer containing at least one yellow coupler, characterised in that the red-sensitive layer contains at least one oil former, the cyan coupler is of the formula in which R1 means a hydrogen atom or an alkyl group, R2 means an alkyl, aryl or hetaryl group, R3 means an alkyl or aryl group, R4 means an alkyl, alkenyl, alkoxy, aryloxy, acyloxy, acylamino, sulfonyloxy, sulfamoylamino, sulfonamido, ureido, hydroxycarbonyl, hydroxycarbonylamino, carbamoyl, alkylthio, arylthio, alkylamino or arylamino group or a hydrogen atom and Z means a hydrogen atom or a group eliminable under the conditions of chromogenic development, and the ratio by weight of oil former to cyan coupler is less than 1:1, is distinguished by excType: GrantFiled: July 2, 2003Date of Patent: October 19, 2004Assignee: Agfa-GevaertInventors: Ralf Weimann, Markus Geiger, Cuong Ly, Klaus Sinzger, Beate Weber, Heinz Wiesen
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Patent number: 6783924Abstract: A color photographic silver halide material comprising a substrate, at least one red-sensitive silver halide emulsion layer containing at least one cyan coupler, at least one green-sensitive silver halide emulsion layer containing at least one magenta coupler and at least one blue-sensitive silver halide emulsion layer containing at least one yellow coupler, characterised in that the silver halide crystals of the red-sensitive layer have a chloride content of at least 95 mol %, the cyan coupler corresponding to formula wherein R1 represents a hydrogen atom or an alkyl group, R2 represents an alkyl, aryl or hetaryl group R3 represents an alkyl or aryl group, R4 represents an alkyl, alkenyl, alkoxy, aryloxy, acyloxy, acylamino, sulphonyloxy, sulphamoylamino, sulphonamido, ureido, hydroxycarbonyl, hydroxycarbonylamino, carbamoyl, alkylthio, arylthio, alkylamino or arylamino group or a hydrogen atom and Z represents a hydrogen atom or a group which may be split off under the conditions of cType: GrantFiled: July 2, 2003Date of Patent: August 31, 2004Assignee: Agfa-GevaertInventors: Ralf Weimann, Markus Geiger, Cuong Ly, Klaus Sinzger, Beate Weber, Heinz Wiesen
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Publication number: 20040110103Abstract: A colour photographic silver halide material comprising a substrate, at least one red-sensitive silver halide emulsion layer containing at least one cyan coupler, at least one green-sensitive silver halide emulsion layer containing at least one magenta coupler and at least one blue-sensitive silver halide emulsion layer containing at least one yellow coupler, characterised in that the silver halide crystals of the red-sensitive layer have a chloride content of at least 95 mol %, the cyan coupler corresponding to formula 1Type: ApplicationFiled: July 2, 2003Publication date: June 10, 2004Applicant: Agfa-Gevaert (Belgium)Inventors: Ralf Weimann, Markus Geiger, Cuong Ly, Klaus Sinzger, Beate Weber, Heinz Wiesen
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Patent number: 6689552Abstract: A color photographic silver halide material which can be developed to form a negative, at least 95 mol % of the silver halides of which consist of AgCl, and which contains at least one light-sensitive silver halide emulsion layer, the silver halide of which contains at least one compound of formulae (I), (II) and (III): [IrClnF6-n]2−M2+ (I) wherein n denotes 0 or an integer from 1 to 6 and M2+ denotes 1 or 2 cations with a total number of 2 positive charges, [Fe(CN)6]m−Mm+ (II) wherein m denotes 2 or 3 and Mm+ denotes 1 to 3 cations with a total number of m positive charges, wherein o denotes 0, 1 or 2 and R denotes an alkyl, aryl or aralkyl, is distinguished under scanning exposure and on analogue exposure by sharp contrast which is independent of exposure time and by a stable latent image.Type: GrantFiled: November 5, 2001Date of Patent: February 10, 2004Assignee: Agfa-GevaertInventors: Cuong Ly, Edgar Draber, Matthias Feigl, Günter Helling, Thomas Kaluschke, Michael Missfeldt, Maria Nietgen, Heinz-Horst Teitscheid, Ralf Weimann, Heinz Wiesen
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Publication number: 20040023171Abstract: A print material having a support, at least one red-sensitive silver halide emulsion layer containing at least one cyan coupler, at least one green-sensitive silver halide emulsion layer containing at least one magenta coupler and at least one blue-sensitive silver halide emulsion layer containing at least one yellow coupler, characterised in that the red-sensitive layer contains at least one oil former, the cyan coupler is of the formula 1Type: ApplicationFiled: July 2, 2003Publication date: February 5, 2004Applicant: Agfa-Gevaert N.V. (Belgium)Inventors: Ralf Weimann, Markus Geiger, Cuong Ly, Klaus Sinzger, Beate Weber, Heinz Wiesen
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Publication number: 20040023173Abstract: A print material having a support, at least one red-sensitive silver halide emulsion layer containing at least one cyan coupler, at least one green-sensitive silver halide emulsion layer containing at least one magenta coupler and at least one blue-sensitive silver halide emulsion layer containing at least one yellow coupler, characterised in that the silver halide crystals of the red-sensitive layer have a chloride content of at least 95 mol %, contain 20 to 500 nmol of iridium per mol of silver halide and the cyan coupler is of the formula 1Type: ApplicationFiled: July 2, 2003Publication date: February 5, 2004Applicant: Agfa-GevaertInventors: Ralf Weimann, Markus Geiger, Cuong Ly, Klaus Sinzger, Beate Weber, Heinz Wiesen
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Publication number: 20030064331Abstract: A color photographic silver halide material which can be developed to form a negative, at least 95 mol % of the silver halides of which consist of AgCl, and which contains at least one light-sensitive silver halide emulsion layer, the silver halide of which contains at least one compound of formulae (I), (II) and (III):Type: ApplicationFiled: November 5, 2001Publication date: April 3, 2003Inventors: Cuong Ly, Edgar Draber, Matthias Feigl, Gunter Helling, Thomas Kaluschke, Michael Missfeldt, Maria Nietgen, Heinz-Horst Teitscheid, Ralf Weimann, Heinz Wiesen
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Patent number: 6284447Abstract: A color photographic silver halide material which is developed as a negative, at least 90 mol % of the silver halides of which consist of AgCl, and which contains a compound of formula (I) or formula (II) in a light-insensitive layer which is further from the support than is each light—light sensitive layer, is distinguished by its improved color reproduction.Type: GrantFiled: April 7, 2000Date of Patent: September 4, 2001Assignee: Agfa-GevaertInventors: Cuong Ly, Dieter Rockser, Edgar Draber, Markus Geiger, Jürgen Heinecke, Randolph Trommer
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Patent number: 6194135Abstract: A negatively developing color photographic silver halide material having a support and at least one blue-sensitive silver halide emulsion layer containing at least one yellow coupler, at least one green-sensitive silver halide emulsion layer containing at least one magenta coupler and at least one red-sensitive silver halide emulsion layer containing at least one cyan coupler, at least 95 mol % of the silver halides of which consist of AgCl, and in which at least one silver halide emulsion layer exhibits solarization on analogue exposure, is distinguished on scanning exposure by elevated color density and on analogue exposure by contrast which is independent of exposure time.Type: GrantFiled: October 22, 1999Date of Patent: February 27, 2001Assignee: Agfa-Gevaert Naamloze VennootschapInventors: Cuong Ly, Stefan Amann, Jürgen Jung, Dieter Rockser
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Patent number: 6171776Abstract: A colour photographic silver halide material in which at least one of the blue-sensitive silver halide emulsions is spectrally sensitised with a mixture of at least one seansitising dye of the formula (I) and at least one sensitising dye of the formula (II): in which R1 means an optionally substituted thienyl, pyrroly, indolyl, furamyl or phenyl, in which R5, R6, R7, mean H or R5 and R6 together or R6 and R7 together mean the remaining members of a fused benzo ring and the residual substituent means H and R2, R3, R4, R8, R9, R10 and M have the meaning stated in the description, is distinguished by elevated sensitivity and improved latent image stabilitity.Type: GrantFiled: December 10, 1998Date of Patent: January 9, 2001Assignee: Agfa N.V.Inventors: Cuong Ly, Michael Missfeldt, Heinz-Horst Teitscheid, Edgar Draber
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Patent number: 6159675Abstract: A colour photographic material having a support and at least one silver halide emulsion layer containing couplers, which layer contains as couplers a 2-equivalent magenta coupler and both at least one compound of the formula (III) and at least one compound of the formula (IV): ##STR1## in which R.sub.4 to R.sub.9 and n have the meaning stated in the description, is distinguished by reduced pressure sensitivity.Type: GrantFiled: May 25, 1999Date of Patent: December 12, 2000Assignee: Agfa-Gevaert Naamloze VennootschapInventors: Cuong Ly, Matthias Feigl, Markus Geiger
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Patent number: 6077657Abstract: A color photographic silver halide material having a support and at least one silver halide emulsion layer containing couplers, which layer contains as couplers a 2-equivalent magenta coupler and both at least one compound of the formula (III) and at least one compound of the formula (IV): ##STR1## in which R.sub.4 means H, alkoxy or alkylmercapto,R.sub.5 means alkyl, halogen or R.sub.4,R.sub.7 means OH, NHCHO, NHCONH-alkyl, CO-alkyl, COOH, COO-alkyl, CONH.sub.2, SO.sub.3 H, SO.sub.2 NH-alkyl, CH.sub.2 CH.sub.2 COOH andR.sub.7 means H, alkyl, halogen, OH or alkoxyis distinguished by improved pressure sensitivity.Type: GrantFiled: June 30, 1999Date of Patent: June 20, 2000Assignee: Agfa-Gevaert N.V.Inventors: Cuong Ly, Matthias Feigl, Markus Geiger
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Patent number: 6063557Abstract: A color photographic silver halide material in which at least one of the blue-sensitive silver halide emulsions is doped with mercury and is spectrally sensitised with a sensitising dye of formula (I) ##STR1## wherein X.sub.1 and X.sub.2, independently of each other, denote O, S, Se, NR,R denotes alkyl or carboxyalkyl,R.sub.1 and R.sub.2 or R.sub.2 and R.sub.3 denote the remaining members for the completion of a phenanthro- or anthraazole ring, and the remaining R.sub.1 or R.sub.3 radical denotes a hydrogen atom,R.sub.4 and R.sub.5, independently of each other, denote a hydrogen atom, alkyl or aryl, orR.sub.4 and R.sub.5 jointly denote the remaining members of an unsubstituted or substituted benzazole, naphthazole, phenanthro- or anthraazole,S.sub.1 and S.sub.2, independently of each other, denote alkyl, sulphoallyl or carboxyalkyl, andM.sup.+ denotes a cation which is possibly necessary for charge equalisation,is distinguished by an improved latent image stability.Type: GrantFiled: September 2, 1998Date of Patent: May 16, 2000Assignee: Agfa-Gevaert N.V.Inventors: Cuong Ly, Maria Nietgen, Michael Missfeldt, Heinz-Horst Teitscheid, Edgar Draber, Markus Geiger