Patents by Inventor Curie Ahn

Curie Ahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic pig which simultaneously expresses HO-1 gene and TNFR1-Fc gene, and comprises knocked-out GGTA1 gene, and use thereof
    Patent number: 10717991
    Abstract: The present invention relates to a transgenic pig in which an immune rejection response is suppressed during xenotransplantation, wherein a gene coding for heme oxygenase-1 (HO-1) and a gene coding for tumor necrosis factor receptor 1-Fc (TNFR1-Fc) are simultaneously expressed and a gene coding for ?-1,3-galactosyltransferase (GGTA1) is knocked out; and a method for producing the same.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: July 21, 2020
    Assignees: CHONG KUN DANG PHARMACEUTICAL CORP., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Byeong Chun Lee, Curie Ahn, Geon A Kim, Su Cheong Yeom, Su Jin Kim, Bumrae Cho, Eun Mi Lee, Sang Hoon Lee, In Chang Hwang, Hye Jin Hong
  • Transgenic pig expressing sTNFR1-Fc genes and the uses thereof
    Patent number: 9357754
    Abstract: The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-? in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: June 7, 2016
    Assignee: SNU R&DB FOUNDATION
    Inventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Byoung Gon Moon, Goo Jang, Bum Rae Cho, Ok Jae Koo, Sol Ji Park, Jung Taek Kang, Dae Kee Kwon
  • Transgenic pig in which HO-1 and TNFR1-Fc are simultaneously expressed, and method for producing same
    Patent number: 9018439
    Abstract: The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fe fusion genes are simultaneously expressed. The present invention also relates to a transgenic pig for organ transplantation, which is produced by the method, and in which immune rejection response is inhibited. The present invention also relates to a somatic-cell-donating cell strain for producing the transgenic pig, and to a method for producing organs, from the transgenic pig, in which the immune rejection response is inhibited.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: April 28, 2015
    Assignee: Hanwha Advanced Materials Corporation
    Inventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Goo Jang, Bum Rae Cho, Ok Jae Koo, Jung Taek Kang, Dae Kee Kwon
  • TRANSGENIC PIG EXPRESSING STNFR1-FC GENES AND THE USES THEREOF
    Publication number: 20140026233
    Abstract: The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-? in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.
    Type: Application
    Filed: January 20, 2012
    Publication date: January 23, 2014
    Applicant: SNU R&DB FOUNDATION
    Inventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Byoung Gon Moon, Goo Jang, Bum Rae Cho, Ok Jae Koo, Sol Ji Park, Jung Taek Kang, Dae Kee Kwon
  • Transgenic Pig in which HO-1 and TNFR1-Fc are Simultaneously Expressed, and Method for Producing Same
    Publication number: 20120278910
    Abstract: The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fe fusion genes are simultaneously expressed. The present invention also relates to a transgenic pig for organ transplantation, which is produced by the method, and in which immune rejection response is inhibited. The present invention also relates to a somatic-cell-donating cell strain for producing the transgenic pig, and to a method for producing organs, from the transgenic pig, in which the immune rejection response is inhibited.
    Type: Application
    Filed: December 21, 2010
    Publication date: November 1, 2012
    Applicant: HANWHA L&C CORPORATION
    Inventors: Curie Ahn, Byeong Chun Lee, Jong Ik Hwang, Jae Seok Yang, Goo Jang, Bum Rae Cho, Ok Jae Koo, Jung Taek Kang, Dae Kee Kwon