Abstract: A method for predicting risk of a future disease condition includes the steps of collecting and transporting bodily fluid to at least one colorimetric analyte sensing element, detecting the presence of bodily fluid, collecting optical data relating to the at least one colorimetric analyte sensing element with at least one spectrophotometer after a predetermined time period after detecting the presence of bodily fluid in contact with the colorimetric analyte sensing element, communicating the optical data to a computing system having at least one processor and data storage, analyzing the optical data to determine at least one analyte concentration in the bodily fluid, identifying a threshold analyte concentration of the at least one analyte in the bodily fluid that is an indicator of the risk of developing a future disease condition; and recording the at least one analyte concentration in the bodily fluid over time.

Abstract: A device for dispensing a fluid topical composition includes a reservoir storing the composition and dispensing a pressurized flow of the composition. The device also includes an accumulator having an expandable chamber in fluidly communication with the reservoir. The chamber is biased towards a deflated configuration so that, when filled with the composition the chamber expands against this bias applying pressure to the composition stored therein. The device includes a supply valve regulating the flow of the composition from the reservoir to the accumulator, and a pressure sensor. The device further includes a processing arrangement analyzing data from the sensor to determine whether pressure in the accumulator is above a predetermined threshold and controlling the supply valve to maintain the pressure within a desired pressure range. The device also includes a deposition arrangement dispensing the composition from the accumulator under control of the processing arrangement.

Abstract: A device for dispensing a fluid topical composition includes a reservoir storing the composition and dispensing a pressurized flow of the composition. The device also includes an accumulator having an expandable chamber in fluidly communication with the reservoir. The chamber is biased towards a deflated configuration so that, when filled with the composition the chamber expands against this bias applying pressure to the composition stored therein. The device includes a supply valve regulating the flow of the composition from the reservoir to the accumulator, and a pressure sensor. The device further includes a processing arrangement analyzing data from the sensor to determine whether pressure in the accumulator is above a predetermined threshold and controlling the supply valve to maintain the pressure within a desired pressure range. The device also includes a deposition arrangement dispensing the composition from the accumulator under control of the processing arrangement.

Abstract: An oral fluids sample collection method and apparatus includes a shield having a first face and a second face; an elastomeric nipple having an outer surface and defining a nipple interior extending from the first face of the shield; and a reservoir component extending from the second face of the shield comprising a reservoir having a reservoir interior. These elements are interconnected by a plurality of fluid conduit/valve combinations, including a first combination permitting flow from the nipple interior to an atmospheric vent port disposed on an exterior surface of the oral fluids collection device; a second combination permitting flow from the reservoir interior to the nipple interior; and a third combination permitting flow from a collection port disposed on the outer surface of the nipple to an exit port in the reservoir interior.

Abstract: A process capable of commercial scale manufacturing of inexpensive, multilayered shaped film product, without the waste of die-cutting and which products are capable of use independent of a supporting structure on which they are formed, includes placing a first mask over a substrate; delivering a first film-forming composition through the first mask to form a first raw shape on the substrate; removing the first mask; placing a second mask over the first raw shape; delivering a second film-forming composition through the second mask to form a second raw shape on the first raw shape; removing the second mask; and solidifying the first and second raw shapes to provide the shaped film product disposed on the substrate.

Abstract: A process capable of commercial scale manufacturing of inexpensive, shaped film products includes placing a mask over a substrate; delivering a film-forming composition through a nozzle to form a raw shape on the substrate; removing the mask; and solidifying the film-forming composition to provide the shaped film product disposed on the substrate. The mask has a delivery surface and an opposite substrate-facing surface and at least one aperture having a design corresponding to the desired shaped film product. The nozzle is disposed in sealing engagement with the delivery surface of the mask to the at least one aperture of the mask during delivery of the film-forming composition.

Abstract: A device for providing nicotine replacement therapy may be provided. The device may comprise a processor. The processor may be configured to perform one or more actions. A cessation program for a user may be determined. A program intervention event based on a phase of the cessation program may be determined. A marker associated with the user may be determined. A modification to the cessation program may be determined based on the program intervention event.

Abstract: A device for providing nicotine replacement therapy may be provided. The device may comprise a dispenser for dispensing a nicotine formulation. The device may comprise an actuating member mounted to actuate the dispenser. The device may comprise a lockout mechanism that may be movable between an operative position that may allow the actuating member to move so as to actuate the dispenser, and a non-operative position that may prevent the actuating member from moving. The device may comprise a processor. The processor may be configured to determine an amount of nicotine that was previously consumed by a user. The processor may be configured to send a lockout mechanism signal to the lockout mechanism that causes the lockout mechanism to move to the non-operative position.

Abstract: A device for providing a beneficial effect to an oral cavity of a mammal, the device providing: a liquid for contacting a plurality of surfaces of the oral cavity, wherein the liquid is effective for providing the beneficial effect to the oral cavity, and reciprocation of the liquid over the plurality of surfaces of the oral cavity under conditions effective to provide the beneficial effect.

Abstract: A system and kit for measuring analyte concentration in a bodily fluid include a durable component, at least one indicator component including an indicator zone, and at least one moisture sensor. The kit has multiple individually packaged indicator components. Methods of measuring analyte concentration in bodily fluids include the steps of collecting and transporting bodily fluid to at least one colorimetric analyte sensing element and detecting the presence of bodily fluid in contact with the at least one colorimetric analyte sensing element, collecting optical data relating to the at least one colorimetric analyte sensing element with at least one spectrophotometer after a predetermined time period after detecting the presence of bodily fluid, communicating the optical data to a computing system having at least one processor and data storage, and analyzing the optical data to determine at least one analyte concentration in the bodily fluid.

Abstract: A method for predicting risk of a future disease condition includes the steps of collecting and transporting bodily fluid to at least one colorimetric analyte sensing element, detecting the presence of bodily fluid, collecting optical data relating to the at least one colorimetric analyte sensing element with at least one spectrophotometer after a predetermined time period after detecting the presence of bodily fluid in contact with the colorimetric analyte sensing element, communicating the optical data to a computing system having at least one processor and data storage, analyzing the optical data to determine at least one analyte concentration in the bodily fluid, identifying a threshold analyte concentration of the at least one analyte in the bodily fluid that is an indicator of the risk of developing a future disease condition; and recording the at least one analyte concentration in the bodily fluid over time.

Abstract: A disposable indicator component for use in a system for measuring analyte concentration in a bodily fluid includes an indicator zone comprising at least one colorimetric analyte sensing element, and a coupler for coupling the indicator component to a component having at least one spectrophotometer contained within a housing.

Abstract: A method for providing a beneficial effect to an oral cavity of a mammal, the method including contacting a plurality of surfaces of the oral cavity with a liquid effective for providing the beneficial effect to the oral cavity and providing reciprocation of the liquid over the plurality of surfaces of the oral cavity under conditions effective to provide the beneficial effect.

Abstract: A device for applying a composition to a skin of a face includes an end effector having a base portion and a protruding portion extending distally from the base portion. The protruding portion has a distal opening. The device also includes a detector arrangement obtaining image data corresponding to an image of an area of the skin through the distal opening and an applicator arrangement applying the composition to a location within the area. The device further includes a processing arrangement receiving and analyzing the image data to determine whether the applicator is aimed to safely dispense the composition to the area and whether a frexel within the area corresponds to a skin artifact, and directing the applicator to selectively apply the composition to the frexel when the applicator is aimed to safely dispense the composition to the area and the skin artifact is detected from the frexel.

Abstract: A system for delivering energy to an isolated part of a mammalian body includes an electrically powered patch and a self-supporting adhesive film. The patch has a major surface and comprises a matrix of at least one flexible, biocompatible material which is capable of conforming to the isolated body part. The self-supporting adhesive film has a first non-tacky surface arranged and configured for releasable attachment to the patch and a second tacky surface, opposite the first surface, for adhesive attachment to the isolated body part. The releasable attachment between the self-supporting adhesive film and the electrically powered patch has a lower strength than the adhesive attachment between the film and the isolated body part. Thus, during use the electrically powered patch is removable from the self-supporting adhesive film while leaving the self-supporting adhesive film adhered to the isolated body part.

Abstract: A device for dispensing a fluid topical composition includes a reservoir storing the composition and dispensing a pressurized flow of the composition. The device also includes an accumulator having an expandable chamber in fluidly communication with the reservoir. The chamber is biased towards a deflated configuration so that, when filled with the composition the chamber expands against this bias applying pressure to the composition stored therein. The device includes a supply valve regulating the flow of the composition from the reservoir to the accumulator, and a pressure sensor. The device further includes a processing arrangement analyzing data from the sensor to determine whether pressure in the accumulator is above a predetermined threshold and controlling the supply valve to maintain the pressure within a desired pressure range. The device also includes a deposition arrangement dispensing the composition from the accumulator under control of the processing arrangement.

Abstract: A process capable of commercial scale manufacturing of inexpensive, shaped film products includes placing a mask over a substrate; delivering a film-forming composition through a nozzle to form a raw shape on the substrate; removing the mask; and solidifying the film-forming composition to provide the shaped film product disposed on the substrate. The mask has a delivery surface and an opposite substrate-facing surface and at least one aperture having a design corresponding to the desired shaped film product. The nozzle is disposed in sealing engagement with the delivery surface of the mask to the at least one aperture of the mask during delivery of the film-forming composition.

Abstract: A process capable of commercial scale manufacturing of inexpensive, shaped film products includes placing a mask over a substrate; delivering a film-forming composition through a nozzle to form a raw shape on the substrate; removing the mask; and solidifying the film-forming composition to provide the shaped film product disposed on the substrate. The mask has a delivery surface and an opposite substrate-facing surface and at least one aperture having a design corresponding to the desired shaped film product. The nozzle is disposed in sealing engagement with the delivery surface of the mask to the at least one aperture of the mask during delivery of the film-forming composition.

Abstract: A phototherapy system wearable on a portion of a user's face includes a lamp platform and a controller unit disposed on, and electrically coupled to, the lamp platform, and a frame for holding the lamp platform in a fixed orientation on a user's face. The controller unit has an inwardly facing surface directed toward the user's face during use; a rechargeable power source; and a charging receptacle disposed in the inwardly facing surface and in electrical communication with the charging receptacle. In use, the frame holds the lamp platform and controller unit in a relationship such that the spacing between the charging receptacle and a closest surface of the user's face defines a charging receptacle clearance.

Abstract: A process capable of commercial scale manufacturing of inexpensive, multilayered shaped film product, without the waste of die-cutting and which products are capable of use independent of a supporting structure on which they are formed, includes placing a first mask over a substrate; delivering a first film-forming composition through the first mask to form a first raw shape on the substrate; removing the first mask; placing a second mask over the first raw shape; delivering a second film-forming composition through the second mask to form a second raw shape on the first raw shape; removing the second mask; and solidifying the first and second raw shapes to provide the shaped film product disposed on the substrate.