Patents by Inventor CURT DEISTER
CURT DEISTER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250157233Abstract: Techniques are described for determining the quality of a nerve graft by assessing quantitative structural characteristics of the nerve graft. Aspects of the techniques include obtaining an image identifying laminin-containing tissue in the nerve graft; creating a transformed image using a transformation function of an image processing application on the image; using an analysis function of the image processing application, analyzing the transformed image to identify one or more structures in accordance with one or more recognition criteria; and determining one or more structural characteristics of the nerve graft derived from a measurement of the one or more structures.Type: ApplicationFiled: January 16, 2025Publication date: May 15, 2025Applicant: Axogen CorporationInventor: Curt DEISTER
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Patent number: 12285299Abstract: The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.Type: GrantFiled: October 25, 2021Date of Patent: April 29, 2025Assignee: Axogen CorporationInventors: Curt Deister, Crystal Simon, Jennifer Faleris
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Patent number: 12279916Abstract: The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.Type: GrantFiled: February 10, 2021Date of Patent: April 22, 2025Assignee: Axogen CorporationInventors: Curt Deister, Crystal Simon, Jennifer Faleris
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Patent number: 12263276Abstract: The invention provides method for preparing amnion tissue grafts, as well as the grafts themselves. In specific embodiments, the tissue graft comprises a single layer of dried amnion from an umbilical cord.Type: GrantFiled: January 13, 2023Date of Patent: April 1, 2025Assignee: Axogen CorporationInventor: Curt Deister
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Publication number: 20240238583Abstract: An electrical stimulation device may include a handle having a proximal end, a distal end, one or more actuators, and a display. The electrical stimulation device may also include a probe attached to and extending from the distal end of the handle, the probe including a stimulation portion and a return portion, wherein a spacing between the stimulation portion and the return portion is adjustable.Type: ApplicationFiled: January 16, 2024Publication date: July 18, 2024Applicant: Axogen CorporationInventors: Brian ROMOT, Kasra TAJDARAN, Justin DEUERLING, Curt DEISTER
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Publication number: 20240241104Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.Type: ApplicationFiled: March 29, 2024Publication date: July 18, 2024Applicant: Axogen CorporationInventor: Curt DEISTER
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Publication number: 20240216582Abstract: The present disclosure provides engineered nerve grafts, methods of making engineered nerve grafts, and methods of using an engineered nerve graft to repair a nerve. Engineered nerve grafts of the present disclosure may include a body extending from a first end to a second end, the body being formed of a biocompatible hydrogel, and a plurality of microchannels extending continuously through the body from the first end to the second end, wherein each of the plurality of microchannels may have an effective diameter of about 1 micrometer to about 200 micrometers.Type: ApplicationFiled: December 7, 2023Publication date: July 4, 2024Applicant: Axogen CorporationInventors: Nikunj Kumar AGRAWAL, Curt DEISTER
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Publication number: 20240144705Abstract: Techniques are described for determining the quality of a nerve graft by assessing quantitative structural characteristics of the nerve graft. Aspects of the techniques include obtaining an image identifying laminin-containing tissue in the nerve graft; creating a transformed image using a transformation function of an image processing application on the image; using an analysis function of the image processing application, analyzing the transformed image to identify one or more structures in accordance with one or more recognition criteria; and determining one or more structural characteristics of the nerve graft derived from a measurement of the one or more structures.Type: ApplicationFiled: November 3, 2023Publication date: May 2, 2024Applicant: Axogen CorporationInventor: Curt DEISTER
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Patent number: 11959903Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.Type: GrantFiled: September 17, 2021Date of Patent: April 16, 2024Assignee: Axogen CorporationInventor: Curt Deister
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Publication number: 20240058027Abstract: A capture-tool for manipulation of tissue utilizes vacuum to hold the tissue in place. An extension attached to a vacuum source at one end and a vacuum arm at another end creates a vacuum force through the extension and vacuum arm. The vacuum arm has a support surface with ports therein at which low pressure areas are formed by the vacuum force. The low pressure areas draw tissue against the supporting surface to hold it in place, as long as the vacuum force is active.Type: ApplicationFiled: October 27, 2023Publication date: February 22, 2024Applicant: Axogen CorporationInventors: Jennifer Faleris, Anne Engemann, Curt Deister
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Patent number: 11885792Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.Type: GrantFiled: September 20, 2021Date of Patent: January 30, 2024Assignee: Axogen CorporationInventor: Curt Deister
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Publication number: 20240009348Abstract: A multi-layer amnion product may include a plurality of layers oriented on top of one another, wherein the plurality of layers includes at least one chorion membrane layer and at least two amnion layers. The plurality of layers may include at least four layers and less than ten layers. At least two of the at least two amnion layers may form outermost layers of the plurality of layers. Each amnion layer may include an epithelial layer, a basement membrane, and a fibroblast layer, and each chorion layer may include a reticular layer and a basement membrane.Type: ApplicationFiled: July 5, 2023Publication date: January 11, 2024Applicant: Axogen CorporationInventors: Kiri K. HAMAKER, Alec SIMON, Curt DEISTER, Erick DEVINNEY, Mark FRIEDMAN
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Patent number: 11847844Abstract: Techniques are described for determining the quality of a nerve graft by assessing quantitative structural characteristics of the nerve graft. Aspects of the techniques include obtaining an image identifying laminin-containing tissue in the nerve graft; creating a transformed image using a transformation function of an image processing application on the image; using an analysis function of the image processing application, analyzing the transformed image to identify one or more structures in accordance with one or more recognition criteria; and determining one or more structural characteristics of the nerve graft derived from a measurement of the one or more structures.Type: GrantFiled: August 18, 2020Date of Patent: December 19, 2023Assignee: Axogen CorporationInventor: Curt Deister
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Publication number: 20230201577Abstract: An electrode apparatus may include a handle, a cannula extending from a distal end of the handle and having at least one lumen, a ground wire extending through the cannula, and an electrode wire extending through the handle and the cannula, the electrode wire being extendable and retractable relative to a distal end of the cannula. The apparatus may also include a hook, provided in the cannula, and being extendable and retractable relative to the cannula.Type: ApplicationFiled: October 31, 2022Publication date: June 29, 2023Applicant: Axogen CorporationInventors: Brian ROMOT, Justin DEUERLING, Curt DEISTER, Angelo SCOPELIANOS, Robert C. DILUCCIO
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Publication number: 20230191001Abstract: The invention provides method for preparing amnion tissue grafts, as well as the grafts themselves. In specific embodiments, the tissue graft comprises a single layer of dried amnion from an umbilical cord.Type: ApplicationFiled: January 13, 2023Publication date: June 22, 2023Applicant: Axogen CorporationInventor: Curt DEISTER
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Publication number: 20230129433Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing neurons (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on nerve growth.Type: ApplicationFiled: October 25, 2022Publication date: April 27, 2023Applicant: Axogen CorporationInventors: Curt DEISTER, Kasra TAJDARAN
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Patent number: 11589870Abstract: The problem of positioning one or more nerve ends inside a sheathing implant is solved by the use of a pulley and cinching systems that pull a nerve end into an implant and that can adjust the diameter of an implant to conform the implant to the diameter of the nerve, respectively. The pulley system utilizes a suture that traverses the wall of an implant leaving one end outside the implant wall and another end that can be attached to a nerve. Pulling the suture end outside the wall pulls the nerve attached to the other end of the suture into the bore of the implant. A cinching system utilizes specially arranged sutures within the wall of an implant to tighten or cinch up the wall after a nerve is placed therein, so as to conform at least part of the implant to the diameter of the nerve. Methods are also disclosed by which such pulley systems can be formed during an intraoperative procedure.Type: GrantFiled: January 27, 2021Date of Patent: February 28, 2023Assignee: Axogen CorporationInventor: Curt Deister
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Patent number: 11577001Abstract: The invention provides method for preparing amnion tissue grafts, as well as the grafts themselves. In specific embodiments, the tissue graft comprises a single layer of dried amnion from an umbilical cord.Type: GrantFiled: November 2, 2017Date of Patent: February 14, 2023Assignee: Axogen CorporationInventor: Curt Deister
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Patent number: 11513039Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing neurons (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on nerve growth.Type: GrantFiled: May 25, 2016Date of Patent: November 29, 2022Assignee: Axogen CorporationInventors: Curt Deister, Kasra Tajdaran
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Publication number: 20220346818Abstract: A capture-tool for manipulation of tissue utilizes vacuum to hold the tissue in place. An extension attached to a vacuum source at one end and a vacuum arm at another end creates a vacuum force through the extension and vacuum arm. The vacuum arm has a support surface with ports therein at which low pressure areas are formed by the vacuum force. The low pressure areas draw tissue against the supporting surface to hold it in place, as long as the vacuum force is active.Type: ApplicationFiled: July 7, 2022Publication date: November 3, 2022Applicant: Axogen CorporationInventors: Jennifer Faleris, Anne Engemann, Curt Deister