Patents by Inventor CURT DEISTER

CURT DEISTER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250157233
    Abstract: Techniques are described for determining the quality of a nerve graft by assessing quantitative structural characteristics of the nerve graft. Aspects of the techniques include obtaining an image identifying laminin-containing tissue in the nerve graft; creating a transformed image using a transformation function of an image processing application on the image; using an analysis function of the image processing application, analyzing the transformed image to identify one or more structures in accordance with one or more recognition criteria; and determining one or more structural characteristics of the nerve graft derived from a measurement of the one or more structures.
    Type: Application
    Filed: January 16, 2025
    Publication date: May 15, 2025
    Applicant: Axogen Corporation
    Inventor: Curt DEISTER
  • Patent number: 12285299
    Abstract: The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: April 29, 2025
    Assignee: Axogen Corporation
    Inventors: Curt Deister, Crystal Simon, Jennifer Faleris
  • Patent number: 12279916
    Abstract: The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be configured with flaps that can be used to widen the open end for easier insertion of the nerve into the cap. In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: April 22, 2025
    Assignee: Axogen Corporation
    Inventors: Curt Deister, Crystal Simon, Jennifer Faleris
  • Patent number: 12263276
    Abstract: The invention provides method for preparing amnion tissue grafts, as well as the grafts themselves. In specific embodiments, the tissue graft comprises a single layer of dried amnion from an umbilical cord.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: April 1, 2025
    Assignee: Axogen Corporation
    Inventor: Curt Deister
  • Publication number: 20240238583
    Abstract: An electrical stimulation device may include a handle having a proximal end, a distal end, one or more actuators, and a display. The electrical stimulation device may also include a probe attached to and extending from the distal end of the handle, the probe including a stimulation portion and a return portion, wherein a spacing between the stimulation portion and the return portion is adjustable.
    Type: Application
    Filed: January 16, 2024
    Publication date: July 18, 2024
    Applicant: Axogen Corporation
    Inventors: Brian ROMOT, Kasra TAJDARAN, Justin DEUERLING, Curt DEISTER
  • Publication number: 20240241104
    Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.
    Type: Application
    Filed: March 29, 2024
    Publication date: July 18, 2024
    Applicant: Axogen Corporation
    Inventor: Curt DEISTER
  • Publication number: 20240216582
    Abstract: The present disclosure provides engineered nerve grafts, methods of making engineered nerve grafts, and methods of using an engineered nerve graft to repair a nerve. Engineered nerve grafts of the present disclosure may include a body extending from a first end to a second end, the body being formed of a biocompatible hydrogel, and a plurality of microchannels extending continuously through the body from the first end to the second end, wherein each of the plurality of microchannels may have an effective diameter of about 1 micrometer to about 200 micrometers.
    Type: Application
    Filed: December 7, 2023
    Publication date: July 4, 2024
    Applicant: Axogen Corporation
    Inventors: Nikunj Kumar AGRAWAL, Curt DEISTER
  • Publication number: 20240144705
    Abstract: Techniques are described for determining the quality of a nerve graft by assessing quantitative structural characteristics of the nerve graft. Aspects of the techniques include obtaining an image identifying laminin-containing tissue in the nerve graft; creating a transformed image using a transformation function of an image processing application on the image; using an analysis function of the image processing application, analyzing the transformed image to identify one or more structures in accordance with one or more recognition criteria; and determining one or more structural characteristics of the nerve graft derived from a measurement of the one or more structures.
    Type: Application
    Filed: November 3, 2023
    Publication date: May 2, 2024
    Applicant: Axogen Corporation
    Inventor: Curt DEISTER
  • Patent number: 11959903
    Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: April 16, 2024
    Assignee: Axogen Corporation
    Inventor: Curt Deister
  • Publication number: 20240058027
    Abstract: A capture-tool for manipulation of tissue utilizes vacuum to hold the tissue in place. An extension attached to a vacuum source at one end and a vacuum arm at another end creates a vacuum force through the extension and vacuum arm. The vacuum arm has a support surface with ports therein at which low pressure areas are formed by the vacuum force. The low pressure areas draw tissue against the supporting surface to hold it in place, as long as the vacuum force is active.
    Type: Application
    Filed: October 27, 2023
    Publication date: February 22, 2024
    Applicant: Axogen Corporation
    Inventors: Jennifer Faleris, Anne Engemann, Curt Deister
  • Patent number: 11885792
    Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: January 30, 2024
    Assignee: Axogen Corporation
    Inventor: Curt Deister
  • Publication number: 20240009348
    Abstract: A multi-layer amnion product may include a plurality of layers oriented on top of one another, wherein the plurality of layers includes at least one chorion membrane layer and at least two amnion layers. The plurality of layers may include at least four layers and less than ten layers. At least two of the at least two amnion layers may form outermost layers of the plurality of layers. Each amnion layer may include an epithelial layer, a basement membrane, and a fibroblast layer, and each chorion layer may include a reticular layer and a basement membrane.
    Type: Application
    Filed: July 5, 2023
    Publication date: January 11, 2024
    Applicant: Axogen Corporation
    Inventors: Kiri K. HAMAKER, Alec SIMON, Curt DEISTER, Erick DEVINNEY, Mark FRIEDMAN
  • Patent number: 11847844
    Abstract: Techniques are described for determining the quality of a nerve graft by assessing quantitative structural characteristics of the nerve graft. Aspects of the techniques include obtaining an image identifying laminin-containing tissue in the nerve graft; creating a transformed image using a transformation function of an image processing application on the image; using an analysis function of the image processing application, analyzing the transformed image to identify one or more structures in accordance with one or more recognition criteria; and determining one or more structural characteristics of the nerve graft derived from a measurement of the one or more structures.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: December 19, 2023
    Assignee: Axogen Corporation
    Inventor: Curt Deister
  • Publication number: 20230201577
    Abstract: An electrode apparatus may include a handle, a cannula extending from a distal end of the handle and having at least one lumen, a ground wire extending through the cannula, and an electrode wire extending through the handle and the cannula, the electrode wire being extendable and retractable relative to a distal end of the cannula. The apparatus may also include a hook, provided in the cannula, and being extendable and retractable relative to the cannula.
    Type: Application
    Filed: October 31, 2022
    Publication date: June 29, 2023
    Applicant: Axogen Corporation
    Inventors: Brian ROMOT, Justin DEUERLING, Curt DEISTER, Angelo SCOPELIANOS, Robert C. DILUCCIO
  • Publication number: 20230191001
    Abstract: The invention provides method for preparing amnion tissue grafts, as well as the grafts themselves. In specific embodiments, the tissue graft comprises a single layer of dried amnion from an umbilical cord.
    Type: Application
    Filed: January 13, 2023
    Publication date: June 22, 2023
    Applicant: Axogen Corporation
    Inventor: Curt DEISTER
  • Publication number: 20230129433
    Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing neurons (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on nerve growth.
    Type: Application
    Filed: October 25, 2022
    Publication date: April 27, 2023
    Applicant: Axogen Corporation
    Inventors: Curt DEISTER, Kasra TAJDARAN
  • Patent number: 11589870
    Abstract: The problem of positioning one or more nerve ends inside a sheathing implant is solved by the use of a pulley and cinching systems that pull a nerve end into an implant and that can adjust the diameter of an implant to conform the implant to the diameter of the nerve, respectively. The pulley system utilizes a suture that traverses the wall of an implant leaving one end outside the implant wall and another end that can be attached to a nerve. Pulling the suture end outside the wall pulls the nerve attached to the other end of the suture into the bore of the implant. A cinching system utilizes specially arranged sutures within the wall of an implant to tighten or cinch up the wall after a nerve is placed therein, so as to conform at least part of the implant to the diameter of the nerve. Methods are also disclosed by which such pulley systems can be formed during an intraoperative procedure.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: February 28, 2023
    Assignee: Axogen Corporation
    Inventor: Curt Deister
  • Patent number: 11577001
    Abstract: The invention provides method for preparing amnion tissue grafts, as well as the grafts themselves. In specific embodiments, the tissue graft comprises a single layer of dried amnion from an umbilical cord.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: February 14, 2023
    Assignee: Axogen Corporation
    Inventor: Curt Deister
  • Patent number: 11513039
    Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing neurons (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on nerve growth.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: November 29, 2022
    Assignee: Axogen Corporation
    Inventors: Curt Deister, Kasra Tajdaran
  • Publication number: 20220346818
    Abstract: A capture-tool for manipulation of tissue utilizes vacuum to hold the tissue in place. An extension attached to a vacuum source at one end and a vacuum arm at another end creates a vacuum force through the extension and vacuum arm. The vacuum arm has a support surface with ports therein at which low pressure areas are formed by the vacuum force. The low pressure areas draw tissue against the supporting surface to hold it in place, as long as the vacuum force is active.
    Type: Application
    Filed: July 7, 2022
    Publication date: November 3, 2022
    Applicant: Axogen Corporation
    Inventors: Jennifer Faleris, Anne Engemann, Curt Deister