Patents by Inventor Curt William Bradshaw

Curt William Bradshaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR TREATING A DISEASE OR CONDITION ASSOCIATED WITH ABNORMAL ANGIOGENESIS
    Publication number: 20150057431
    Abstract: The present invention provides methods of treating (including preventing) a disease or condition associated with abnormal angiogenesis in a subject include administering a therapeutically effective amount of an AA targeting compound of the invention to the subject. The AA targeting compounds comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody.
    Type: Application
    Filed: October 31, 2014
    Publication date: February 26, 2015
    Inventors: Curt William BRADSHAW, Abhijit Suresh BHAT, Jing-Yu LAI, Venkata R. DOPPALAPUDI, Dingguo LIU
  • Anti-angiogenic compounds
    Patent number: 8937048
    Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: January 20, 2015
    Assignee: Covx Technologies Ireland, Limited
    Inventors: Venkata Ramana Doppalapudi, Jing-Yu Lai, Bin Liu, Dingguo Liu, Joel Desharnais, Abhijit Suresh Bhat, Yanwen Fu, Bryan Douglas Oates, Gang Chen, Curt William Bradshaw
  • Multifunctional antibody conjugates
    Patent number: 8741291
    Abstract: The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL?) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: June 3, 2014
    Assignee: Covx Technologies Ireland, Limited
    Inventors: Abhijit Suresh Bhat, Curt William Bradshaw, Olivier Alexandre Laurent, Alice Lee, Richard Ryan Preston, David Tumelty, Lauren Diane Wood, Wei Hong Yu
  • ANTI-ANGIOGENIC COMPOUNDS
    Publication number: 20120321591
    Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 20, 2012
    Inventors: Venkata Ramana Doppalapudi, Jing-Yu Lai, Bin Liu, Dingguo Liu, Joel Desharnais, Abhijit Suresh Bhat, Yanwen Fu, Bryan Douglas Oates, Gang Chen, Curt William Bradshaw
  • Anti-angiogenic compounds
    Patent number: 8293714
    Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: October 23, 2012
    Assignee: Covx Technology Ireland, Ltd.
    Inventors: Venkata Ramana Doppalapudi, Jing-Yu Lai, Bin Liu, Dingguo Liu, Joel Desharnais, Abhijit Suresh Bhat, Yanwen Fu, Bryan Douglas Oates, Gang Chen, Curt William Bradshaw
  • Anti-angiogenic compounds
    Patent number: 8288349
    Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
    Type: Grant
    Filed: November 12, 2007
    Date of Patent: October 16, 2012
    Assignee: Covx Technology Ireland, Ltd.
    Inventors: Curt William Bradshaw, Abhijit Suresh Bhat, Jing-Yu Lai, Venkata R. Doppalapudi, Dingguo Liu
  • MULTIFUNCTIONAL ANTIBODY CONJUGATES
    Publication number: 20120201809
    Abstract: The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL?) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.
    Type: Application
    Filed: November 28, 2011
    Publication date: August 9, 2012
    Applicant: COVX TECHNOLOGIES IRELAND, LIMITED
    Inventors: Abhijit Suresh Bhat, Curt William Bradshaw, Olivier Alexandre Laurent, Alice Lee, Richard Ryan Preston, David Tumelty, Lauren Diane Wood, Wei Hong Yu
  • ANTI-ANGIOGENIC COMPOUNDS
    Publication number: 20100003267
    Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
    Type: Application
    Filed: April 29, 2009
    Publication date: January 7, 2010
    Inventors: Venkata Ramana Doppalapudi, Jing-Yu Lai, Bin Liu, Dingguo Liu, Joel Desharnais, Abhijit Suresh Bhat, Yanwen Fu, Bryan Douglas Oates, Gang Chen, Curt William Bradshaw