Abstract: Disclosed is a device for determining a concentration of cells of a given size in a sample of fluid, the sample comprising a plurality of cells, comprising: a light source arranged to emit light along a central axis to illuminate the plurality of cells in the fluid sample; a detector arranged to receive light at a plurality of displacements from the central axis, the light having passed through the plurality of cells in the fluid sample, and to produce a plurality of signals, each associated with, and indicative of an intensity of the received light at, a respective one of the plurality of displacements; and a processor arranged to determine a concentration of cells of a given size, based on the plurality of signals from the detector, wherein the processor is arranged to compare the plurality of signals from the detector with one or more pre-stored thresholds or profiles, indicative of a particular concentration.

Abstract: A method for delivering a benefit agent to the surface of the eye, the method comprising applying an ocular benefit composition to a lid margin of the eye wherein the ocular benefit composition comprises at least 5 wt % of one or more lipid and/or lipid derived compounds.

Abstract: A fastening system comprising a second fastener fastened to a first fastener; the first fastener comprising a hollow housing having a side-wall and a top-wall; a first aperture formed in the side-wall and in the top-wall of the hollow housing, the first aperture configured for entry of the second fastener during fastening of the second fastener and first fastener; a second aperture formed in the side-wall of the hollow housing; a beam formed in the side-wall between the first aperture and the second aperture, the beam attached at opposing ends to the side-wall; the beam blocks the first aperture to inhibit separation of the second fastener from the first fastener through the first aperture; and the beam is configured to be deformed during fastening of the second fastener to the first fastener.

Abstract: A method for delivering a benefit agent to the surface of the eye, the method comprising applying an ocular benefit composition to a lid margin of the eye wherein the ocular benefit composition comprises at least 5 wt % of one or more lipid and/or lipid derived compounds.

Abstract: A fastening system comprising a second fastener fastened to a first fastener; the first fastener comprising a hollow housing having a side-wall and a top-wall; a first aperture formed in the side-wall and in the top-wall of the hollow housing, the first aperture configured for entry of the second fastener during fastening of the second fastener and first fastener; a second aperture formed in the side-wall of the hollow housing; a beam formed in the side-wall between the first aperture and the second aperture, the beam attached at opposing ends to the side-wall; the beam blocks the first aperture to inhibit separation of the second fastener from the first fastener through the first aperture; and the beam is configured to be deformed during fastening of the second fastener to the first fastener.

Abstract: The present invention relates to a miniature device for detecting, identifying and/or quantifying microorganisms in a sample. The device comprises a surface for contact with a sample to be analysed, said surface defining a pore and said pore comprising means for reporting the presence of a microorganism. The reporting means may comprise a solid or semi-solid substrate, a metabolic indicator; and a media and/or nutrients that support or encourage microbial growth.

Abstract: The present invention relates to a miniature device for detecting, identifying and/or quantifying microorganisms in a sample. The device comprises a surface for contact with a sample to be analysed, said surface defining a pore and said pore comprising means for reporting the presence of a microorganism. The reporting means may comprise a solid or semi-solid substrate, a metabolic indicator; and a media and/or nutrients that support or encourage microbial growth.

Abstract: The present invention relates to the use of a polypeptides, comprising repeats of a peptide derived from a Heparan Sulphate Proteoglycan (HSPG) receptor binding region of an apolipoprotein, for treating or preventing a fungal and/or protist infection. The invention further relates to the use of such peptides for treating or preventing the contamination of surfaces or objects with such peptides.

Abstract: The present invention relates to the use of a polypeptides, comprising repeats of a peptide derived from a Heparan Sulphate Proteoglycan (HSPG) receptor binding region of an apolipoprotein, for treating or preventing a fungal and/or protist infection. The invention further relates to the use of such peptides for treating or preventing the contamination of surfaces or objects with such peptides.

Abstract: The present invention relates to a miniature device for detecting, identifying and/or quantifying microorganisms in a sample. The device comprises a surface for contact with a sample to be analysed, said surface defining a pore and said pore comprising means for reporting the presence of a microorganism. The reporting means may comprise a solid or semi-solid substrate, a metabolic indicator; and a media and/or nutrients that support or encourage microbial growth.

Abstract: The invention relates to polypeptides, comprising repeats of peptides derived from apolipoproteins, which exhibit antibacterial activity and to nucleic acids encoding the same. The invention further provides the use of such polypeptides, derivatives, analogues or nucleic acids as medicaments, and also their use in methods of preventing or treating bacterial infection or objects and surfaces. The invention further extends to objects, such as contact lenses, coated with the polypeptides.

Abstract: The present invention concerns polypeptides derived from a tandem repeat of apoE141-149 and their uses as medicaments. The peptides may comprise the tandem repeat, and truncations thereof, for which at least one Leucine (L) is replaced by an amino acid with a side chain comprising at least 4 carbon atoms and at least one Nitrogen atom. Such peptides are useful for preventing or treating viral infections.

Abstract: The present invention relates to the use of a polypeptides, comprising repeats of a peptide derived from a Heparan Sulphate Proteoglycan (HSPG) receptor binding region of an apolipoprotein, for treating or preventing a fungal and/or protist infection. The invention further relates to the use of such peptides for treating or preventing the contamination of surfaces or objects with such peptides.

Abstract: The present invention relates to polypeptides, and derivatives or analogues thereof, comprising a tandem repeat of apolipoprotein B, or a truncation thereof, derived from an HSPG receptor binding region of apolipoprotein B. Such peptides are useful for treating or preventing the development of viral infections.

Abstract: The present invention concerns polypeptides derived from a tandem repeat of apoE141-149 and their uses as medicaments. The peptides may comprise the tandem repeat, and truncations thereof, for which at least one Leucine (L) is replaced by an amino acid with a side chain comprising at least 4 carbon atoms and at least one Nitrogen atom. Such peptides are useful for preventing or treating viral infections.

Abstract: The present invention concerns polypeptides derived from a tandem repeat of apoE141-149 and their uses as medicaments. The peptides may comprise the tandem repeat, and truncations thereof, for which at least one Leucine (L) is replaced by an amino acid with a side chain comprising at least 4 carbon atoms and at least one Nitrogen atom. Such peptides are useful for preventing or treating viral infections.

Abstract: The present invention relates to polypeptides, and derivatives or analogues thereof, comprising a tandem repeat of apolipoprotein B, or a truncation thereof, derived from an HSPG receptor binding region of apolipoprotein B. Such peptides are useful for treating or preventing the development of viral infections.

Abstract: The present invention relates to the use of a polypeptides, comprising repeats of a peptide derived from a Heparan Sulphate Proteoglycan (HSPG) receptor binding region of an apolipoprotein, for treating or preventing a fungal and/or protist infection. The invention further relates to the use of such peptides for treating or preventing the contamination of surfaces or objects with such peptides.

Abstract: The present invention concerns polypeptides derived from a tandem repeat of apoE141-149 and their uses as medicaments. The peptides may comprise the tandem repeat, and truncations thereof, for which at least one Leucine (L) is replaced by an amino acid with a side chain comprising at least 4 carbon atoms and at least one Nitrogen atom. Such peptides are useful for preventing or treating viral infections.