Abstract: A preferred embodiment is provided that utilizes psychedelics that induce the shortest possible hallucinogenic experience, to facilitate the use of fast-acting, short duration anesthetics that creates a state of unconsciousness that eliminates and/or minimizes conscious awareness and/or recall of the hallucinogenic experience. The preferred embodiment facilitates critical brain processes and activities than can potentiate the actions of psychedelics such processing supporting neurogenesis, synaptogenesis while blocking inflammatory cytokine activity particularly in the brain and potentiating the activity of anti-inflammatory cytokines.

Abstract: Systems and methods for the evaluation of clinical treatment efficacy is disclosed. The systems and methods include protocols for selection of appropriate patients/subjects for the evaluation of a specific clinical treatment. The systems and methods are based on objective measures of brain activity. The clinical treatments include pharmacological compounds in development or existing compounds approved by the appropriate regulatory authority (e.g., U.S. Federal Drug Administration), as well as transcranial magnetic or electric stimulation, including non-invasive approaches as well as grid- or depth-based electrode arrays, as well as behavioral therapies.

Abstract: The present invention provides a method of overcoming the contamination of physiological signals with noise caused by characteristics of the electrical supply to measuring devices. The method exploits the periodic and spectrally stationary nature of noise. The method can be implemented in software for easy calculation and display of calculated results for interpretation and use of the resulting relatively uncontaminated signals. The method can be applied where measurements are made of physiological parameters of humans or any other animal. The invention includes apparatus for acquiring and processing physiological signals from a subject included at least one sensor for acquiring at least one signal and at least one microprocessor means for processing the at least one signal, the microprocessor means including means for storing a whole number multiple of an artefact waveform for calculating the line-noise component of data derived from the at least one sensor.

Abstract: A sensor assembly for the measurement of electrophysiological signals and including a conductive bridge is provided. In one embodiment, the conductive bridge is provided by an expandable member with an absorbent material attached to one end. An aperture extends through the expandable member, forming a cavity well. Addition of a conductive medium to the cavity well allows the conductive bridge to provide a conductive pathway between an electrode and a patient's skin.