Abstract: The present invention is directed to an ambulatory infusion device having a housing which has a series of cavities in which there are provided expandable pressure regulator tubes which may be formed of suitable resilient materials. The regulator tubes may be of several different configurations. The cavities have a greater volume than the expandable tubes to permit expansion thereof and also to provide means for limiting the expansion thereof to ensure against bursting of the tubes should a pressure relief valve in the system fail to operate. The open ends of the regulator tubes are interconnected through a series of passageways, connectors, etc. to an inflatable, flexible, substantially non-stretchable diaphragm provided in another housing cavity. A fresh flexible bag of medicament is positioned against the diaphragm by the patient with an administration port of the bag projecting outwardly of the housing for connection to an infusion set connectable to a patient's catheter.

Abstract: A clamp for dividing a flexible bag includes three pivotally joined members. A sealing member has a sealing surface such as an extended bead. A center member has a first face having an undercut groove forming a pair of arms to engage the sealing surface and the flexible bag. A second face has a locking groove. A locking member has a wedge portion engageable in the locking groove so as to deflect the arms around the sealing surface.